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http://hdl.handle.net/1942/38095
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DC Field | Value | Language |
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dc.contributor.author | Tjahjadi, Catherina | - |
dc.contributor.author | Fortuni, Federico | - |
dc.contributor.author | STASSEN, Jan | - |
dc.contributor.author | Debonnaire, Philippe | - |
dc.contributor.author | Lustosa, Rodolfo P. | - |
dc.contributor.author | Marsan, Nina Ajmone | - |
dc.contributor.author | Delgado, Victoria | - |
dc.contributor.author | Bax, Jeroen J. | - |
dc.date.accessioned | 2022-09-19T07:25:48Z | - |
dc.date.available | 2022-09-19T07:25:48Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-09-07T13:30:16Z | - |
dc.identifier.citation | The American journal of cardiology, 173 , p. 120 -127 | - |
dc.identifier.uri | http://hdl.handle.net/1942/38095 | - |
dc.description.abstract | Left ventricular (LV) systolic dysfunction in cardiac amyloidosis (CA) is associated with poor prognosis. This study aimed to investigate the prognostic implications of right ventricular (RV) systolic dysfunction in CA. A total of 93 patients diagnosed with CA who underwent standard and speckle-tracking echocardiography were included. During a median follow-up of 17 (5 to 38) months, 42 patients (45%) died. Nonsurvivors were more likely to present with immunoglobulin light-chain amyloidosis and New York Heart Association class III to IV heart failure symptoms. Regarding the echocardiographic characteristics, nonsurvivors had a higher LV apical ratio, worse LV diastolic function, and worse RV systolic function (evaluated with both tricuspid annular plane systolic excursion and RV free wall strain). RV free wall strain was independently associated with all-cause mortality in several multivariable Cox regression models and had incremental prognostic value over conventional parameters of RV function when added to a basal model (including heart failure symptoms, amyloidosis phenotype, and LV global longitudinal strain). Based on spline curve analysis and Youden index, a value of 16% for RV free wall strain was identified as the optimal cutoff to predict outcome and patients with RV free wall strain <16% had a significantly worse short- and long-term survival during follow-up (1- and 3-year cumulative survival: 81% vs 31% and 67% vs 20%, respectively, p <0.001). In conclusion, RV systolic dysfunction is independently associated with poor outcome in patients with CA and the use of advanced echocardiographic parameters, such as RV free wall strain, may be of aid for better risk stratification. (C) 2022 The Author(s). Published by Elsevier Inc. | - |
dc.description.sponsorship | Dr. Bax received speaking fees from Abbott Vascular. Dr. Marsan received speaking fees from Abbott Vascular and GE Healthcare. Dr. Delgado received speaker fees from Abbott Vascular, Medtronic, Merck Sharp & Dohme, Edwards Lifesciences, and GE Healthcare (Little Chalfont, United Kingdom). The remaining authors have no conflicts of interest to declare. | - |
dc.language.iso | en | - |
dc.publisher | EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC | - |
dc.rights | 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license www.ajconline.org (http://creativecommons.org/licenses/by/4.0/) | - |
dc.subject.other | Humans | - |
dc.subject.other | Prognosis | - |
dc.subject.other | Ventricular Function, Right | - |
dc.subject.other | Amyloidosis | - |
dc.subject.other | Cardiomyopathies | - |
dc.subject.other | Heart Failure | - |
dc.subject.other | Ventricular Dysfunction, Left | - |
dc.subject.other | Ventricular Dysfunction, Right | - |
dc.title | Prognostic Implications of Right Ventricular Systolic Dysfunction in Cardiac Amyloidosis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 127 | - |
dc.identifier.spage | 120 | - |
dc.identifier.volume | 173 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Bax, JJ (corresponding author), Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands. | - |
dc.description.notes | j.j.bax@lumc.nl | - |
local.publisher.place | 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.amjcard.2022.02.048 | - |
dc.identifier.pmid | 35369931 | - |
dc.identifier.isi | 000840111500008 | - |
dc.contributor.orcid | Lustosa, Rodolfo/0000-0001-6421-3505; Bax, Jeroen/0000-0001-7368-0500; | - |
dc.contributor.orcid | Fortuni, Federico/0000-0001-6905-9439; Stassen, Jan/0000-0001-9745-5498 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Tjahjadi, Catherina; Fortuni, Federico; Stassen, Jan; Debonnaire, Philippe; Lustosa, Rodolfo P.; Marsan, Nina Ajmone; Delgado, Victoria; Bax, Jeroen J.] Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands. | - |
local.description.affiliation | [Fortuni, Federico] San Giovanni Battista Hosp, Dept Cardiol, Foligno, Italy. | - |
local.description.affiliation | [Stassen, Jan] Jessa Hosp, Dept Cardiol, Hasselt, Belgium. | - |
local.description.affiliation | [Debonnaire, Philippe] Sint Jan Hosp Bruges, Dept Cardiol, Brugge, Belgium. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Tjahjadi, Catherina; Fortuni, Federico; STASSEN, Jan; Debonnaire, Philippe; Lustosa, Rodolfo P.; Marsan, Nina Ajmone; Delgado, Victoria & Bax, Jeroen J. (2022) Prognostic Implications of Right Ventricular Systolic Dysfunction in Cardiac Amyloidosis. In: The American journal of cardiology, 173 , p. 120 -127. | - |
item.fulltext | With Fulltext | - |
item.contributor | Tjahjadi, Catherina | - |
item.contributor | Fortuni, Federico | - |
item.contributor | STASSEN, Jan | - |
item.contributor | Debonnaire, Philippe | - |
item.contributor | Lustosa, Rodolfo P. | - |
item.contributor | Marsan, Nina Ajmone | - |
item.contributor | Delgado, Victoria | - |
item.contributor | Bax, Jeroen J. | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 0002-9149 | - |
crisitem.journal.eissn | 1879-1913 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Prognostic Implications of Right Ventricular Systolic Dysfunction in Cardiac Amyloidosis.pdf | Published version | 794.26 kB | Adobe PDF | View/Open |
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