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http://hdl.handle.net/1942/38102
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DC Field | Value | Language |
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dc.contributor.author | GOJEVIC, Tin | - |
dc.contributor.author | VAN RYCKEGHEM, Lisa | - |
dc.contributor.author | Jogani, Siddharth | - |
dc.contributor.author | FREDERIX, Ines | - |
dc.contributor.author | Bakelants , Elise | - |
dc.contributor.author | Petit, Thibault | - |
dc.contributor.author | Stroobants , Sarah | - |
dc.contributor.author | DENDALE, Paul | - |
dc.contributor.author | BITO, Virginie | - |
dc.contributor.author | HERBOTS, Lieven | - |
dc.contributor.author | HANSEN, Dominique | - |
dc.contributor.author | VERWERFT, Jan | - |
dc.date.accessioned | 2022-09-19T08:44:53Z | - |
dc.date.available | 2022-09-19T08:44:53Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-08-25T09:30:33Z | - |
dc.identifier.citation | European journal of preventive cardiology (Print), 30 (1), p. 37-45 | - |
dc.identifier.uri | http://hdl.handle.net/1942/38102 | - |
dc.description.abstract | Aims To compare the cardiac function and pulmonary vascular function during exercise between dyspnoeic and non-dyspnoeic patients with Type 2 diabetes mellitus (T2DM). Methods and results Forty-seven T2DM patients with unexplained dyspnoea and 50 asymptomatic T2DM patients underwent exercise echocardiography combined with ergospirometry. Left ventricular (LV) function [stroke volume, cardiac output (CO), LV ejection fraction, systolic annular velocity (s ')], estimated LV filling pressures (E/e '), mean pulmonary arterial pressures (mPAPs) and mPAP/COslope were assessed at rest, low- and high-intensity exercise with colloid contrast. Groups had similar patient characteristics, glycemic control, stroke volume, CO, LV ejection fraction, and E/e ' (P > 0.05). The dyspnoeic group had significantly lower systolic LV reserve at peak exercise (s ') (P = 0.021) with a significant interaction effect (P < 0.001). The dyspnoeic group also had significantly higher mPAP and mPAP/CO at rest and exercise (P < 0.001) with significant interaction for mPAP (P < 0.009) and insignificant for mPAP/CO (P = 0.385). There was no significant difference in mPAP/COslope between groups (P = 0.706). However, about 61% of dyspnoeic vs. 30% of non-dyspnoeic group had mPAP/COslope > 3 (P = 0.009). The mPAP/COslope negatively predicted V?O-2peak in dyspneic group (beta = -1.86, 95% CI: -2.75, -0.98; multivariate model R-2:0.54). Conclusion Pulmonary hypertension and less LV systolic reserve detected by exercise echocardiography with colloid contrast underlie unexplained exertional dyspnoea and reduced exercise capacity in T2DM. | - |
dc.description.sponsorship | This research was supported by an unrestricted research grant of Heart Centre Hasselt and by internal funding from the Faculty of Rehabilitation Sciences of Hasselt University, Hasselt, Belgium. | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.rights | The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please email: journals.permissions@oup.com. | - |
dc.subject.other | Diabetes | - |
dc.subject.other | Heart | - |
dc.subject.other | Echocardiography | - |
dc.subject.other | Shortness of breath | - |
dc.subject.other | Pulmonary arterial pressure | - |
dc.title | Pulmonary hypertension during exercise underlies unexplained exertional dyspnoea in patients with Type 2 diabetes | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 45 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 37 | - |
dc.identifier.volume | 30 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Gojevic, T (corresponding author), Hasselt Univ, Fac Rehabil Sci, REVAL Rehabil Res Ctr, Agoralaan,Bldg A, B-3590 Diepenbeek, Belgium.; Gojevic, T (corresponding author), Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Ctr, B-3500 Diepenbeek, Belgium. | - |
dc.description.notes | tin.gojevic@uhasselt.be | - |
local.publisher.place | GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1093/eurjpc/zwac153 | - |
dc.identifier.pmid | 35881689 | - |
dc.identifier.isi | 000838695100001 | - |
dc.contributor.orcid | Verwerft, Jan/0000-0003-2697-0825; Bito, Virginie/0000-0003-0986-7906 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Gojevic, Tin; Van Ryckeghem, Lisa; Hansen, Dominique] Hasselt Univ, Fac Rehabil Sci, REVAL Rehabil Res Ctr, Agoralaan,Bldg A, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Gojevic, Tin; Van Ryckeghem, Lisa; Dendale, Paul; Bito, Virginie; Hansen, Dominique] Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Ctr, B-3500 Diepenbeek, Belgium. | - |
local.description.affiliation | [Jogani, Siddharth; Bakelants, Elise; Petit, Thibault; Stroobants, Sarah; Dendale, Paul; Herbots, Lieven; Hansen, Dominique; Verwerft, Jan] Jessa Hosp, Heart Ctr Hasselt, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Frederix, Ines] Zuyderland MC, Dept Cardiol, NL-6419 PC Heerlen, Netherlands. | - |
local.description.affiliation | [Frederix, Ines] Antwerp Univ, Fac Med & Hlth Sci, B-2610 Antwerp, Belgium. | - |
local.description.affiliation | [Bakelants, Elise] Geneva Univ Hosp, Dept Cardiol, CH-1205 Geneva, Switzerland. | - |
local.description.affiliation | [Dendale, Paul; Hansen, Dominique; Verwerft, Jan] Hasselt Univ, Fac Med & Life Sci, B-3500 Hasselt, Belgium. | - |
local.uhasselt.international | yes | - |
item.contributor | GOJEVIC, Tin | - |
item.contributor | VAN RYCKEGHEM, Lisa | - |
item.contributor | Jogani, Siddharth | - |
item.contributor | FREDERIX, Ines | - |
item.contributor | Bakelants , Elise | - |
item.contributor | Petit, Thibault | - |
item.contributor | Stroobants , Sarah | - |
item.contributor | DENDALE, Paul | - |
item.contributor | BITO, Virginie | - |
item.contributor | HERBOTS, Lieven | - |
item.contributor | HANSEN, Dominique | - |
item.contributor | VERWERFT, Jan | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2023 | - |
item.fullcitation | GOJEVIC, Tin; VAN RYCKEGHEM, Lisa; Jogani, Siddharth; FREDERIX, Ines; Bakelants , Elise; Petit, Thibault; Stroobants , Sarah; DENDALE, Paul; BITO, Virginie; HERBOTS, Lieven; HANSEN, Dominique & VERWERFT, Jan (2022) Pulmonary hypertension during exercise underlies unexplained exertional dyspnoea in patients with Type 2 diabetes. In: European journal of preventive cardiology (Print), 30 (1), p. 37-45. | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 2047-4873 | - |
crisitem.journal.eissn | 2047-4881 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Pulmonary hypertension during exercise underlies unexplained exertional dyspnoea in patients with Type 2 diabetes.pdf Restricted Access | Published version | 3.59 MB | Adobe PDF | View/Open Request a copy |
Pulmonary hypertension.pdf | Peer-reviewed author version | 1.44 MB | Adobe PDF | View/Open |
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