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http://hdl.handle.net/1942/38124
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DC Field | Value | Language |
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dc.contributor.author | Butler, Javed | - |
dc.contributor.author | Anker, Stefan D. | - |
dc.contributor.author | Lund, Lars H. | - |
dc.contributor.author | Coats, Andrew J. S. | - |
dc.contributor.author | Filippatos, Gerasimos | - |
dc.contributor.author | Siddiqi, Tariq Jamal | - |
dc.contributor.author | Friede, Tim | - |
dc.contributor.author | Fabien, Vincent | - |
dc.contributor.author | Kosiborod, Mikhail | - |
dc.contributor.author | Metra, Marco | - |
dc.contributor.author | Pina, Ileana L. | - |
dc.contributor.author | Pinto, Fausto | - |
dc.contributor.author | Rossignol, Patrick | - |
dc.contributor.author | van der Meer, Peter | - |
dc.contributor.author | Bahit, Cecilia | - |
dc.contributor.author | Belohlavek, Jan | - |
dc.contributor.author | Boehm, Michael | - |
dc.contributor.author | Brugts, Jasper J. | - |
dc.contributor.author | Cleland, John G. F. | - |
dc.contributor.author | Ezekowitz, Justin | - |
dc.contributor.author | Bayes-Genis, Antoni | - |
dc.contributor.author | Gotsman, Israel | - |
dc.contributor.author | Goudev, Assen | - |
dc.contributor.author | Khintibidze, Irakli | - |
dc.contributor.author | Lindenfeld, Joann | - |
dc.contributor.author | Mentz, Robert J. | - |
dc.contributor.author | Merkely, Bela | - |
dc.contributor.author | Montes, Eliodoro Castro | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | Nicolau, Jose C. | - |
dc.contributor.author | Parkhomenko, Aleksandr | - |
dc.contributor.author | Ponikowski, Piotr | - |
dc.contributor.author | Seferovic, Petar M. | - |
dc.contributor.author | Senni, Michele | - |
dc.contributor.author | Shlyakhto, Evgeny | - |
dc.contributor.author | Cohen-Solal, Alain | - |
dc.contributor.author | Szecsoedy, Peter | - |
dc.contributor.author | Jensen, Klaus | - |
dc.contributor.author | Dorigotti, Fabio | - |
dc.contributor.author | Weir, Matthew R. | - |
dc.contributor.author | Pitt, Bertram | - |
dc.date.accessioned | 2022-09-21T06:56:52Z | - |
dc.date.available | 2022-09-21T06:56:52Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-09-07T13:41:21Z | - |
dc.identifier.citation | European heart journal, | - |
dc.identifier.uri | http://hdl.handle.net/1942/38124 | - |
dc.description.abstract | Aims To investigate the impact of patiromer on the serum potassium level and its ability to enable specified target doses of renin-angiotensin-aldosterone system inhibitor (RAASi) use in patients with heart failure and reduced ejection fraction (HFrEF). Methods and results A total of 1642 patients with HFrEF and current or a history of RAASi-related hyperkalemia were screened and 1195 were enrolled in the run-in phase with patiromer and optimization of the RAASi therapy [>= 50% recommended dose of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker/angiotensin receptor-neprilysin inhibitor, and 50 mg of mineralocorticoid receptor antagonist (MRA) spironolactone or eplerenone]. Specified target doses of the RAASi therapy were achieved in 878 (84.6%) patients; 439 were randomized to patiromer and 439 to placebo. All patients, physicians, and outcome assessors were blinded to treatment assignment. The primary endpoint was between-group difference in the adjusted mean change in serum potassium. Five hierarchical secondary endpoints were assessed. At the end of treatment, the median (interquartile range) duration of follow-up was 27 (13-43) weeks, the adjusted mean change in potassium was +0.03 mmol/l in the patiromer group and +0.13 mmol/l in the placebo group [difference in the adjusted mean change between patiromer and placebo: -0.10 mmol/l (95% confidence interval, CI -0.13, 0.07); P < 0.001]. Risk of hyperkalemia >5.5 mmol/l [hazard ratio (HR) 0.63; 95% CI 0.45, 0.87; P = 0.006), reduction of MRA dose (HR 0.62; 95% CI 0.45, 0.87; P = 0.006), and total adjusted hyperkalemia events/100 person-years (77.7 vs. 118.2; HR 0.66; 95% CI 0.53, 0.81; P < 0.001) were lower with patiromer. Hyperkalemia-related morbidity-adjusted events (win ratio 1.53, P < 0.001) and total RAASi use score (win ratio 1.25, P = 0.048) favored the patiromer arm. Adverse events were similar between groups. Conclusion Concurrent use of patiromer and high-dose MRAs reduces the risk of recurrent hyperkalemia (ClinicalTrials.gov: NCT03888066). | - |
dc.description.sponsorship | This work was supported by Vifor Pharma. Funding to pay the Open Access publication charge for this article was provided by Vifor Pharma. | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.rights | © The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | - |
dc.subject.other | Heart failure with reduced ejection fraction | - |
dc.subject.other | Renin-angiotensin-aldosterone system inhibitor (RAASi) | - |
dc.subject.other | Hyperkalemia | - |
dc.subject.other | Patiromer | - |
dc.subject.other | Potassium-binding polymer | - |
dc.title | Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial | - |
dc.type | Journal Contribution | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Butler, J (corresponding author), Baylor Scott & White Res Inst, Dallas, TX 75204 USA.; Butler, J (corresponding author), Univ Mississippi, Dept Med, Jackson, MS 39216 USA.; Anker, SD (corresponding author), Dept Cardiol CVK, Berlin, Germany.; Anker, SD (corresponding author), Berlin Inst Hlth Ctr Regenerat Therapies BCRT, Berlin, Germany.; Anker, SD (corresponding author), German Ctr Cardiovasc Res DZHK, Partner Site Berlin, Berlin, Germany.; Anker, SD (corresponding author), Charite, Berlin, Germany. | - |
dc.description.notes | jbutler4@umc.edu; s.anker@cachexia.de | - |
local.publisher.place | GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | Early view | - |
dc.identifier.doi | 10.1093/eurheartj/ehac401 | - |
dc.identifier.pmid | 35900838 | - |
dc.identifier.isi | 000843014600001 | - |
dc.contributor.orcid | Pinto, Fausto J./0000-0002-8034-4529; Lund, Lars H/0000-0003-1411-4482; | - |
dc.contributor.orcid | Metra, Marco/0000-0001-6691-8568; Friede, Tim/0000-0001-5347-7441 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Butler, Javed; Siddiqi, Tariq Jamal] Baylor Scott & White Res Inst, Dallas, TX 75204 USA. | - |
local.description.affiliation | [Butler, Javed; Siddiqi, Tariq Jamal] Univ Mississippi, Dept Med, Jackson, MS 39216 USA. | - |
local.description.affiliation | [Anker, Stefan D.] Dept Cardiol CVK, Berlin, Germany. | - |
local.description.affiliation | [Anker, Stefan D.] Berlin Inst Hlth Ctr Regenerat Therapies BCRT, Berlin, Germany. | - |
local.description.affiliation | [Anker, Stefan D.] German Ctr Cardiovasc Res DZHK, Partner Site Berlin, Berlin, Germany. | - |
local.description.affiliation | [Anker, Stefan D.] Charite, Berlin, Germany. | - |
local.description.affiliation | [Lund, Lars H.] Karolinska Inst, Dept Med, Unit Cardiol, Stockholm, Sweden. | - |
local.description.affiliation | [Lund, Lars H.] Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden. | - |
local.description.affiliation | [Coats, Andrew J. S.] Univ Warwick, Warwick, England. | - |
local.description.affiliation | [Filippatos, Gerasimos] Natl & Kapodistrian Univ Athens, Athens Univ, Sch Med, Athens, Greece. | - |
local.description.affiliation | [Filippatos, Gerasimos] Hosp Attikon, Athens, Greece. | - |
local.description.affiliation | [Friede, Tim] Dept Internal Med, Gottingen, Germany. | - |
local.description.affiliation | [Friede, Tim] Univ Med Ctr Gottingen, Gottingen, Germany. | - |
local.description.affiliation | [Friede, Tim] DZHK German Ctr Cardiovasc Res, Gottingen Partner Site, Gottingen, Germany. | - |
local.description.affiliation | [Fabien, Vincent; Szecsoedy, Peter; Jensen, Klaus; Dorigotti, Fabio] Vifor Pharma, Glattbrugg, Switzerland. | - |
local.description.affiliation | [Kosiborod, Mikhail] St Lukes Mid Amer Heart Inst, Dept Cardiovasc Dis, Kansas City, MO USA. | - |
local.description.affiliation | [Kosiborod, Mikhail] Univ Missouri, Kansas City, MO 64110 USA. | - |
local.description.affiliation | [Metra, Marco] ASST Spedali Civili & Univ, Cardiol, Brescia, Italy. | - |
local.description.affiliation | [Pina, Ileana L.] Cent Michigan Univ, Coll Med, Mt Pleasant, MI 48859 USA. | - |
local.description.affiliation | [Pinto, Fausto] Univ Lisbon, Santa Maria Univ Hosp, CCUL, CAML,Fac Med, Lisbon, Portugal. | - |
local.description.affiliation | [Rossignol, Patrick] X Univ Lorraine, INSERM, Ctr Invest Clin Plurithemat 1433, INSERM Unit 1116,Ctr Hosp Reg Univ CHRU, Nancy, France. | - |
local.description.affiliation | [Rossignol, Patrick] F CRIN INI CRCT, Nancy, France. | - |
local.description.affiliation | [van der Meer, Peter] Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands. | - |
local.description.affiliation | [Bahit, Cecilia] INECO Neurociencias Orono, Santa Fe, NM USA. | - |
local.description.affiliation | [Belohlavek, Jan] Gen Univ Hosp Prague, Clin Cardiol & Angiol, Prague, Czech Republic. | - |
local.description.affiliation | [Boehm, Michael] Saarland Univ, Klin Innere Med 3, Homburg, Germany. | - |
local.description.affiliation | [Brugts, Jasper J.] Erasmus MC Univ Med Ctr, Rotterdam, Netherlands. | - |
local.description.affiliation | [Cleland, John G. F.] Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland. | - |
local.description.affiliation | [Ezekowitz, Justin] Univ Alberta, Fac Med & Dent, Edmonton, AB, Canada. | - |
local.description.affiliation | [Bayes-Genis, Antoni] Hosp Badalona Germans Trias & Pujol, Cardiol Dept, CIBERCV, Barcelona, Spain. | - |
local.description.affiliation | [Gotsman, Israel] Hadassah Med Ctr, Jerusalem, Israel. | - |
local.description.affiliation | [Goudev, Assen] Med Univ Sofia, Dept Emergency Med, Sofia, Bulgaria. | - |
local.description.affiliation | [Khintibidze, Irakli] Tbilisi State Med Univ, Alexandre Aladashvili Clin, Tbilisi, Georgia. | - |
local.description.affiliation | [Lindenfeld, Joann] Vanderbilt Univ Sch Med, Dept Med, Nashville, TN USA. | - |
local.description.affiliation | [Mentz, Robert J.] Duke Univ, Sch Med, Dept Med, Durham, NC 27706 USA. | - |
local.description.affiliation | [Merkely, Bela] Semmelweis Univ, Heart & Vasc Ctr, Budapest, Hungary. | - |
local.description.affiliation | [Montes, Eliodoro Castro] Heart Inst Queretaro, Mexico City, DF, Mexico. | - |
local.description.affiliation | [Mullens, Wilfried] Ziekenhuis Oost Limburg Genk, Genk, Belgium. | - |
local.description.affiliation | [Mullens, Wilfried] Univ Hasselt, Hasselt, Belgium. | - |
local.description.affiliation | [Nicolau, Jose C.] Hosp Clin HCFMUSP, Fac Med, Inst Coracao InCor, Sao Paulo, Brazil. | - |
local.description.affiliation | [Nicolau, Jose C.] Univ Sao Paulo, Sao Paulo, SP, Brazil. | - |
local.description.affiliation | [Parkhomenko, Aleksandr] Hosp Oost Limburg, Genk, Belgium. | - |
local.description.affiliation | [Ponikowski, Piotr] Wroclaw Med Univ, Inst Heart Dis, Wroclaw, Poland. | - |
local.description.affiliation | [Seferovic, Petar M.] Fac Med Belgrade, Belgrade, Serbia. | - |
local.description.affiliation | [Seferovic, Petar M.] Serbian Acad Arts & Sci, Belgrade, Serbia. | - |
local.description.affiliation | [Senni, Michele] Univ Milano Bicocca, Papa Giovanni Hosp 23, Cardiovasc Dept, Bergamo, Italy. | - |
local.description.affiliation | [Shlyakhto, Evgeny] Almazov Fed Heart Blood & Endocrinol Ctr, St Petersburg, Russia. | - |
local.description.affiliation | [Cohen-Solal, Alain] Univ Paris, Hosp Lariboisiere, AP HP, INSERM U942, Paris, France. | - |
local.description.affiliation | [Weir, Matthew R.] Univ Maryland, Sch Med, Dept Med, Div Nephrol, Baltimore, MD 21201 USA. | - |
local.description.affiliation | [Pitt, Bertram] Univ Michigan, Div Cardiol, Ann Arbor, MI 48109 USA. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2023 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | Butler, Javed; Anker, Stefan D.; Lund, Lars H.; Coats, Andrew J. S.; Filippatos, Gerasimos; Siddiqi, Tariq Jamal; Friede, Tim; Fabien, Vincent; Kosiborod, Mikhail; Metra, Marco; Pina, Ileana L.; Pinto, Fausto; Rossignol, Patrick; van der Meer, Peter; Bahit, Cecilia; Belohlavek, Jan; Boehm, Michael; Brugts, Jasper J.; Cleland, John G. F.; Ezekowitz, Justin; Bayes-Genis, Antoni; Gotsman, Israel; Goudev, Assen; Khintibidze, Irakli; Lindenfeld, Joann; Mentz, Robert J.; Merkely, Bela; Montes, Eliodoro Castro; MULLENS, Wilfried; Nicolau, Jose C.; Parkhomenko, Aleksandr; Ponikowski, Piotr; Seferovic, Petar M.; Senni, Michele; Shlyakhto, Evgeny; Cohen-Solal, Alain; Szecsoedy, Peter; Jensen, Klaus; Dorigotti, Fabio; Weir, Matthew R. & Pitt, Bertram (2022) Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial. In: European heart journal,. | - |
item.contributor | Butler, Javed | - |
item.contributor | Anker, Stefan D. | - |
item.contributor | Lund, Lars H. | - |
item.contributor | Coats, Andrew J. S. | - |
item.contributor | Filippatos, Gerasimos | - |
item.contributor | Siddiqi, Tariq Jamal | - |
item.contributor | Friede, Tim | - |
item.contributor | Fabien, Vincent | - |
item.contributor | Kosiborod, Mikhail | - |
item.contributor | Metra, Marco | - |
item.contributor | Pina, Ileana L. | - |
item.contributor | Pinto, Fausto | - |
item.contributor | Rossignol, Patrick | - |
item.contributor | van der Meer, Peter | - |
item.contributor | Bahit, Cecilia | - |
item.contributor | Belohlavek, Jan | - |
item.contributor | Boehm, Michael | - |
item.contributor | Brugts, Jasper J. | - |
item.contributor | Cleland, John G. F. | - |
item.contributor | Ezekowitz, Justin | - |
item.contributor | Bayes-Genis, Antoni | - |
item.contributor | Gotsman, Israel | - |
item.contributor | Goudev, Assen | - |
item.contributor | Khintibidze, Irakli | - |
item.contributor | Lindenfeld, Joann | - |
item.contributor | Mentz, Robert J. | - |
item.contributor | Merkely, Bela | - |
item.contributor | Montes, Eliodoro Castro | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | Nicolau, Jose C. | - |
item.contributor | Parkhomenko, Aleksandr | - |
item.contributor | Ponikowski, Piotr | - |
item.contributor | Seferovic, Petar M. | - |
item.contributor | Senni, Michele | - |
item.contributor | Shlyakhto, Evgeny | - |
item.contributor | Cohen-Solal, Alain | - |
item.contributor | Szecsoedy, Peter | - |
item.contributor | Jensen, Klaus | - |
item.contributor | Dorigotti, Fabio | - |
item.contributor | Weir, Matthew R. | - |
item.contributor | Pitt, Bertram | - |
crisitem.journal.issn | 0195-668X | - |
crisitem.journal.eissn | 1522-9645 | - |
Appears in Collections: | Research publications |
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Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction_ the DIAMOND trial.pdf | Published version | 1.63 MB | Adobe PDF | View/Open |
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