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http://hdl.handle.net/1942/3813
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DC Field | Value | Language |
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dc.contributor.author | ZHANG, JINGWU | - |
dc.contributor.author | MEDAER, Rob | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | HAFLER, D | - |
dc.contributor.author | RAUS, Jef | - |
dc.date.accessioned | 2007-11-29T13:50:17Z | - |
dc.date.available | 2007-11-29T13:50:17Z | - |
dc.date.issued | 1993 | - |
dc.identifier.citation | SCIENCE, 261(5127). p. 1451-1454 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/1942/3813 | - |
dc.description.abstract | Activated autoreactive T cells are potentially pathogenic and regulated by clonotypic networks. Experimental autoimmune diseases can be treated by inoculation with autoreactive T cells (T cell vaccination). In the present study, patients with multiple sclerosis were inoculated with irradiated myelin basic protein (MBP)-reactive T cells. T cell responses to the inoculates were induced to deplete circulating MBP-reactive T cells in the recipients. Regulatory T cell lines isolated from the recipients inhibited T cells used for vaccination. The cytotoxicity of the CDB+ T cell lines was restricted by major histocompatibility antigens. Thus, clonotypic interactions regulating autoreactive T cells in humans can be induced by T cell vaccination. | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | MHC-RESTRICTED DEPLETION OF HUMAN MYELIN BASIC-PROTEIN REACTIVE T-CELLS BY T-CELL VACCINATION | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1454 | - |
dc.identifier.issue | 5127 | - |
dc.identifier.spage | 1451 | - |
dc.identifier.volume | 261 | - |
local.format.pages | 4 | - |
dc.description.notes | DR L WILLEMS INST,DEPT IMMUNOL,B-3590 DIEPENBEEK,BELGIUM. BRIGHAM & WOMENS HOSP,DEPT MED,DIV NEUROL,CTR NEUROL DIS,BOSTON,MA 02115. LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM. HARVARD UNIV,SCH MED,BOSTON,MA 02115.ZHANG, JW, DR L WILLEMS INST,MULTIPLE SCLEROSIS RES UNIT,B-3590 DIEPENBEEK,BELGIUM. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.isi | A1993LW54900034 | - |
item.fulltext | No Fulltext | - |
item.fullcitation | ZHANG, JINGWU; MEDAER, Rob; STINISSEN, Piet; HAFLER, D & RAUS, Jef (1993) MHC-RESTRICTED DEPLETION OF HUMAN MYELIN BASIC-PROTEIN REACTIVE T-CELLS BY T-CELL VACCINATION. In: SCIENCE, 261(5127). p. 1451-1454. | - |
item.accessRights | Closed Access | - |
item.contributor | ZHANG, JINGWU | - |
item.contributor | MEDAER, Rob | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | HAFLER, D | - |
item.contributor | RAUS, Jef | - |
Appears in Collections: | Research publications |
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