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http://hdl.handle.net/1942/3821
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DC Field | Value | Language |
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dc.contributor.author | Maes, Michael | - |
dc.contributor.author | BOSMANS, E | - |
dc.contributor.author | SUY, E | - |
dc.contributor.author | DEJONCKHEERE, C | - |
dc.contributor.author | VANDERVORST, Carine | - |
dc.contributor.author | RAUS, Jef | - |
dc.date.accessioned | 2007-11-29T14:13:10Z | - |
dc.date.available | 2007-11-29T14:13:10Z | - |
dc.date.issued | 1991 | - |
dc.identifier.citation | NEUROPSYCHOBIOLOGY, 24(3). p. 115-120 | - |
dc.identifier.issn | 0302-282X | - |
dc.identifier.uri | http://hdl.handle.net/1942/3821 | - |
dc.description.abstract | We determined the following immune parameters in drug-free, major depressed patients and in age- and sex-matched healthy controls: the number and percentage of interleukin-2 receptor (IL-2R) bearing cells (CD25+, anti-TAC), serum circulating levels of soluble (s)IL-2Rs, the pre- and postdexamethasone phytohemagglutinin (PHA)-induced accumulation of sIL-2Rs in culture supernatant, and the number of T helper (CD4+) and T suppressor (CD8+) cells. In comparison with normal volunteers, patients with major depression had a higher number and percentage of CD25+ cells, higher concentrations of serum circulating sIL-2Rs, higher supernatant sIL-2Rs after stimulation with PHA, and a higher number of CD4+ cells. The CD4+/CD8+ ratio and the number of CD4+ cells were significantly and positively related to the number of cells expressing the CD25+ antigen. These results may indicate that depressed patients display an increased number of T cells in an early phase of activation. | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.subject.other | DEPRESSION; INTERLEUKIN-2; SOLUBLE INTERLEUKIN-2 RECEPTORS; ACTIVATED T-CELLS; FLOW CYTOMETRY | - |
dc.title | IMMUNE DISTURBANCES DURING MAJOR DEPRESSION - UP-REGULATED EXPRESSION OF INTERLEUKIN-2 RECEPTORS | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 120 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 115 | - |
dc.identifier.volume | 24 | - |
local.format.pages | 6 | - |
dc.description.notes | DR WILLEMS INST,DIEPENBEEK,BELGIUM. EUROGENET,TESSENDERLOO,BELGIUM.MAES, M, PSYCHIAT CTR ST JOSEF,ABDIJST 2,B-3751 MUNSTERBILZEN,BELGIUM. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.isi | A1991HG89000003 | - |
item.accessRights | Closed Access | - |
item.fullcitation | Maes, Michael; BOSMANS, E; SUY, E; DEJONCKHEERE, C; VANDERVORST, Carine & RAUS, Jef (1991) IMMUNE DISTURBANCES DURING MAJOR DEPRESSION - UP-REGULATED EXPRESSION OF INTERLEUKIN-2 RECEPTORS. In: NEUROPSYCHOBIOLOGY, 24(3). p. 115-120. | - |
item.contributor | Maes, Michael | - |
item.contributor | BOSMANS, E | - |
item.contributor | SUY, E | - |
item.contributor | DEJONCKHEERE, C | - |
item.contributor | VANDERVORST, Carine | - |
item.contributor | RAUS, Jef | - |
item.fulltext | No Fulltext | - |
Appears in Collections: | Research publications |
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