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http://hdl.handle.net/1942/3827
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DC Field | Value | Language |
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dc.contributor.author | Maes, Michael | - |
dc.contributor.author | DHONDT, P | - |
dc.contributor.author | SUY, E | - |
dc.contributor.author | MINNER, B | - |
dc.contributor.author | VANDERVORST, Carine | - |
dc.contributor.author | RAUS, Jef | - |
dc.date.accessioned | 2007-11-29T14:18:07Z | - |
dc.date.available | 2007-11-29T14:18:07Z | - |
dc.date.issued | 1991 | - |
dc.identifier.citation | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 15(6). p. 781-790 | - |
dc.identifier.issn | 0278-5846 | - |
dc.identifier.uri | http://hdl.handle.net/1942/3827 | - |
dc.description.abstract | 1. Like other authors we have established disturbances in central serotonergic neurotransmission in severely depressed patients by implementing hypothalamic pituitary adrenal (HPA)-axis hormones and prolactin responses to serotonin agonists or precursors. 2. Challenge probes with D,L fenfluramine have yielded controversial results. This substance, however, is not as serotonin-selective as previously believed. 3. Dextro(D)-fenfluramine, the dextrorotatory isomer of fenfluramine, constitutes a specific and potent serotonergic agonist. 4. In the present study the authors determined the following in healthy volunteers, and in depressed inpatients: the adrenocorticotropic hormone (ACTH), beta-endorphin, prolactin and cortisol responses to D-fenfluramine administration (45 mg orally), total L-tryptophan and the 8 a.m. postdexamethasone cortisol values. 5. We found no significant differences in any of the post-D-fenfluramine hormone levels across healthy controls, minor, simple major and melancholic depressives. There were no significant correlations between L-tryptophan or postdexamethasone cortisol on the one hand, and any of the post-D-fenfluramine hormone values on the other. | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject.other | DEPRESSION; DEXAMETHASONE SUPPRESSION TEST; D-FENFLURAMINE; SEROTONERGIC PROBES; TRYPTOPHAN | - |
dc.title | HPA-axis hormones and prolactin responses to dextro-fenfluramine in depressed-patients and healthy controls | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 790 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 781 | - |
dc.identifier.volume | 15 | - |
local.format.pages | 10 | - |
dc.description.notes | PSYCHIAT CTR ST JOSEF,MUNSTERBILZEN,BELGIUM. UNIV DIEPENBEEK,DR WILLEMS INST,DIEPENBEEK,BELGIUM. | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1016/0278-5846(91)90007-N | - |
dc.identifier.isi | A1991GN29700007 | - |
item.fullcitation | Maes, Michael; DHONDT, P; SUY, E; MINNER, B; VANDERVORST, Carine & RAUS, Jef (1991) HPA-axis hormones and prolactin responses to dextro-fenfluramine in depressed-patients and healthy controls. In: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 15(6). p. 781-790. | - |
item.fulltext | No Fulltext | - |
item.contributor | Maes, Michael | - |
item.contributor | DHONDT, P | - |
item.contributor | SUY, E | - |
item.contributor | MINNER, B | - |
item.contributor | VANDERVORST, Carine | - |
item.contributor | RAUS, Jef | - |
item.accessRights | Closed Access | - |
Appears in Collections: | Research publications |
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