Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3860
Title: DISTURBANCES IN ACUTE PHASE PLASMA-PROTEINS DURING MELANCHOLIA - ADDITIONAL EVIDENCE FOR THE PRESENCE OF AN INFLAMMATORY PROCESS DURING THAT ILLNESS
Authors: Maes, Michael
SCHARPE, S
BOSMANS, E
VANDEWOUDE, M
SUY, E
Uyttenbroeck, W.
COOREMAN, W
VANDERVORST, Carine 
RAUS, Jef 
Issue Date: 1992
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Source: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 16(4). p. 501-515
Abstract: 1. Leukocyte enumeration through flow cytometry has revealed that severe depression may be accompanied by a systemic immune activation, indicative of an inflammatory response. The latter condition allegedly involves an important modification of acute phase plasma protein (APP) equilibrium. 2. In order to elucidate whether the state of severe depression is represented by alterations in APPs, the authors measured: alpha-1 antitrypsin (alpha-1AT), alpha-2 macroglobulin (alpha-2M), haptoglobin (Hp), alpha-1 acid glycoprotein (alpha-1S), transferrin (Tf), complement component 4 (C4) and C-reactive protein (CRP). Interleukin-1-beta (II-1-beta) and interleukin-6 (II-6) circulating levels were determined. 3. Hyperhaptoglobinemia and hypotransferrinemia are hallmarks for major depression and depression per se, respectively. The disorders in Hp and Tf circulating levels are highly sensitive to (83%) and specific for (100%) melancholia as opposed to the healthy state. 4. Disorders in both APPs are significantly related to the absolute number of blood monocytes 5. The authors observed a trend towards lower alpha-2M and higher alpha-1S values in severely depressed subjects. Severity of depression was significantly related to Hp and alpha-1S (both positively) and to alpha-2M and Tf (both negatively) values. 6. No significant intercategory differences in C4 could be established, whilst only a few subjects exhibited measurable CRP, II-1-beta and II-6 circulating levels. 7. Our findings may support the hypothesis that depression is accompanied by an inflammatory response.
Notes: UNIV INSTELLING ANTWERP,DEPT CLIN BIOCHEM,B-2610 WILRIJK,BELGIUM. PSYCHIAT CTR WEYBURN,MUNSTERBILZEN,BELGIUM. DEPT INTERNAL MED,ANTWERP,BELGIUM. EUROGENET,TESSENDERLO,BELGIUM. UNIV DIEPENBEEK,DR WILLEMS INST,DIEPENBEEK,BELGIUM.
Keywords: ALPHA-1 ACID GLYCOPROTEIN; ACUTE PHASE PROTEINS; ALPHA; ANTITRYPSIN; COMPLEMENT COMPONENT-4; FLOW CYTOMETRY; DEPRESSION; HAPTOGLOBIN; INFLAMMATION; INTERLEUKIN-1-BETA; INTERLEUKIN-6; ALPHA-2 MACROGLOBULIN; MONOCYTOSIS; PLASMA PROTEINS; C-REACTIVE PROTEIN; TRANSFERRIN
Document URI: http://hdl.handle.net/1942/3860
DOI: 10.1016/0278-5846(92)90056-K
ISI #: A1992HY86500006
Type: Journal Contribution
Appears in Collections:Research publications

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