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http://hdl.handle.net/1942/38677
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DC Field | Value | Language |
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dc.contributor.author | LOIX, Melanie | - |
dc.contributor.author | WOUTERS, Elien | - |
dc.contributor.author | VANHERLE, Sam | - |
dc.contributor.author | Dehairs, Jonas | - |
dc.contributor.author | McManaman, James L. | - |
dc.contributor.author | KEMPS, Hannelore | - |
dc.contributor.author | SWINNEN , Jo | - |
dc.contributor.author | HAIDAR, Mansour | - |
dc.contributor.author | BOGIE, Jeroen | - |
dc.contributor.author | HENDRIKS, Jerome | - |
dc.date.accessioned | 2022-10-03T07:20:19Z | - |
dc.date.available | 2022-10-03T07:20:19Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-09-28T16:36:18Z | - |
dc.identifier.citation | Cellular and molecular life sciences (Print), 79 (10) (Art N° 515) | - |
dc.identifier.uri | http://hdl.handle.net/1942/38677 | - |
dc.description.abstract | Foamy macrophages and microglia containing lipid droplets (LDs) are a pathological hallmark of demyelinating disorders affecting the central nervous system (CNS). We and others showed that excessive accumulation of intracellular lipids drives these phagocytes towards a more inflammatory phenotype, thereby limiting CNS repair. To date, however, the mechanisms underlying LD biogenesis and breakdown in lipid-engorged phagocytes in the CNS, as well as their impact on foamy phagocyte biology and lesion progression, remain poorly understood. Here, we provide evidence that LD-associated protein perilipin-2 (PLIN2) controls LD metabolism in myelin-containing phagocytes. We show that PLIN2 protects LDs from lipolysis-mediated degradation, thereby impairing intracellular processing of myelin-derived lipids in phagocytes. Accordingly, loss of Plin2 stimulates LD turnover in foamy phagocytes, driving them towards a less inflammatory phenotype. Importantly, Plin2-deficiency markedly improves remyelination in the ex vivo brain slice model and in the in vivo cuprizone-induced demyelination model. In summary, we identify PLIN2 as a novel therapeutic target to prevent the pathogenic accumulation of LDs in foamy phagocytes and to stimulate remyelination. | - |
dc.description.sponsorship | The work has been supported by the Flemish Fund for Scientifc Research (FWO Vlaanderen; 1141920N, 1S15519N), and the special research fund UHasselt (BOF). We thank M.P. Tulleners and L. Timmermans for excellent technical assistance. | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER BASEL AG | - |
dc.rights | The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 | - |
dc.subject.other | Lipid droplet associated protein | - |
dc.subject.other | Foamy macrophages | - |
dc.subject.other | Lipolysis | - |
dc.subject.other | Lipophagy | - |
dc.subject.other | Inflammation | - |
dc.title | Perilipin-2 limits remyelination by preventing lipid droplet degradation | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 10 | - |
dc.identifier.volume | 79 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Hendriks, JJA (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Diepenbeek, Belgium.; Hendriks, JJA (corresponding author), Univ MS Ctr Hasselt, Pelt, Belgium. | - |
dc.description.notes | jerome.hendriks@uhasselt.be | - |
local.publisher.place | PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 515 | - |
dc.identifier.doi | 10.1007/s00018-022-04547-0 | - |
dc.identifier.pmid | 36100764 | - |
dc.identifier.isi | 000853348700002 | - |
dc.contributor.orcid | Hendriks, Jerome/0000-0002-7717-8582; Kemps, | - |
dc.contributor.orcid | Hannelore/0000-0001-9248-1697 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Loix, Melanie; Wouters, Elien; Vanherle, Sam; Kemps, Hannelore; Haidar, Mansour; Bogie, Jeroen F. J.; Hendriks, Jerome J. A.] Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Diepenbeek, Belgium. | - |
local.description.affiliation | [Loix, Melanie; Wouters, Elien; Vanherle, Sam; Kemps, Hannelore; Haidar, Mansour; Bogie, Jeroen F. J.; Hendriks, Jerome J. A.] Univ MS Ctr Hasselt, Pelt, Belgium. | - |
local.description.affiliation | [Dehairs, Jonas; Swinnen, Johannes, V] Univ Leuven, LKI Louvain Canc Inst, Dept Oncol, Lab Lipid Metab & Canc,KU Leuven, Leuven, Belgium. | - |
local.description.affiliation | [McManaman, James L.] Univ Colorado, Sch Med, Dept Obstet & Gynaecol, Denver, CO USA. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2023 | - |
item.accessRights | Open Access | - |
item.fullcitation | LOIX, Melanie; WOUTERS, Elien; VANHERLE, Sam; Dehairs, Jonas; McManaman, James L.; KEMPS, Hannelore; SWINNEN , Jo; HAIDAR, Mansour; BOGIE, Jeroen & HENDRIKS, Jerome (2022) Perilipin-2 limits remyelination by preventing lipid droplet degradation. In: Cellular and molecular life sciences (Print), 79 (10) (Art N° 515). | - |
item.fulltext | With Fulltext | - |
item.contributor | LOIX, Melanie | - |
item.contributor | WOUTERS, Elien | - |
item.contributor | VANHERLE, Sam | - |
item.contributor | Dehairs, Jonas | - |
item.contributor | McManaman, James L. | - |
item.contributor | KEMPS, Hannelore | - |
item.contributor | SWINNEN , Jo | - |
item.contributor | HAIDAR, Mansour | - |
item.contributor | BOGIE, Jeroen | - |
item.contributor | HENDRIKS, Jerome | - |
crisitem.journal.issn | 1420-682X | - |
crisitem.journal.eissn | 1420-9071 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Perilipin-2 limits remyelination by preventing lipid droplet degradation.pdf Restricted Access | 17.33 MB | Adobe PDF | View/Open Request a copy | |
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