Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/38688
Title: Heart failure during the COVID-19 pandemic: clinical, diagnostic, management, and organizational dilemmas
Authors: Palazzuoli, Alberto
Metra, Marco
Collins, Sean P.
Adamo, Marianna
Ambrosy, Andrew P.
Antohi, Laura E.
Ben Gal, Tuvia
Farmakis, Dimitrios
Gustafsson, Finn
Hill, Loreena
Lopatin, Yuri
Tramonte, Francesco
Lyon, Alexander
Masip, Josep
Miro, Oscar
Moura, Brenda
MULLENS, Wilfried 
Radu, Razvan, I
Abdelhamid, Magdy
Anker, Stefan
Chioncel, Ovidiu
Issue Date: 2022
Publisher: WILEY PERIODICALS, INC
Source: ESC Heart Failure, 9 (6), P. 3713-3736
Abstract: The coronavirus 2019 (COVID-19) infection pandemic has affected the care of patients with heart failure (HF). Several consensus documents describe the appropriate diagnostic algorithm and treatment approach for patients with HF and associated COVID-19 infection. However, few questions about the mechanisms by which COVID can exacerbate HF in patients with high-risk (Stage B) or symptomatic HF (Stage C) remain unanswered. Therefore, the type of HF occurring during infection is poorly investigated. The diagnostic differentiation and management should be focused on the identification of the HF phenotype, underlying causes, and subsequent tailored therapy. In this framework, the relationship existing between COVID and onset of acute decompensated HF, isolated right HF, and cardiogenic shock is questioned, and the specific management is mainly based on local hospital organization rather than a standardized model. Similarly, some specific populations such as advanced HF, heart transplant, patients with left ventricular assist device (LVAD), or valve disease remain under investigated. In this systematic review, we examine recent advances regarding the relationships between HF and COVID-19 pandemic with respect to epidemiology, pathogenetic mechanisms, and differential diagnosis. Also, according to the recent HF guidelines definition, we highlight different clinical profile identification, pointing out the main concerns in understudied HF populations.
Notes: Palazzuoli, A (corresponding author), Univ Siena, S Maria Alle Scotte Hosp, Cardio Thorac & Vasc Dept, Cardiovasc Dis Unit, I-53100 Siena, Italy.
palazzuoli2@unisi.it
Keywords: COVID-19;Heart failure;Diagnostic differentiation;Management
Document URI: http://hdl.handle.net/1942/38688
ISSN: 2055-5822
e-ISSN: 2055-5822
DOI: 10.1002/ehf2.14118
ISI #: 000854081300001
Rights: © 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Category: A1
Type: Journal Contribution
Validations: ecoom 2023
Appears in Collections:Research publications

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