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Title: | The long-term relation between physical activity and executive function in the Rotterdam Study | Authors: | Galle, Sara A Liu, Jun BONNECHERE, Bruno Amin, Najaf Milders, Maarten M Deijen, Jan Berend Scherder, Erik J A Drent, Madeleine L Voortman, Trudy Ikram, M Arfan van Duijn, Cornelia M |
Issue Date: | 2023 | Publisher: | SPRINGER | Source: | European Journal of Epidemiology, 38 , p. 71-81 | Abstract: | Background Research on the association between physical inactivity and cognitive decline and dementia is dominated by studies with short-term follow-up, that might be biased by reverse causality. Objective Investigate the long-term association between physical activity, cognition, and the rate of age-associated cognitive decline. Methods We investigated the association between late-life physical activity and executive functioning and rate of decline of executive abilities during follow-up of up to 16 years, in 3553 participants of the prospective Rotterdam Study cohort. Measurement took place in 1997–1999, 2002–2004, 2009–2011, and 2014–2015. Results At baseline (age ± 72 years), higher levels of physical activity were associated with higher levels of executive functioning (adjusted mean difference = 0.03, 95% CI: 0.00 ; 0.06, p = 0.03). This difference remained intact up to 16 years of follow-up. The level of physical activity at baseline was unrelated to the rate of decline of executive abilities over time, in the whole group (adjusted mean difference in changetime*physical activity = 0.00, 95% CI: -0.00 ; 0.01, p = 0.31). However, stratification by APOE genotype showed that the accelerated decline of executive abilities observed in those with the ApoE-ε4 allele might be attenuated by higher levels of physical activity in late adulthood (ApoE-ε4 carriers: Btime*physical activity = 0.01, 95% CI: 0.00 ; 0.01, p = 0.03). Conclusion Higher levels of physical activity in late adulthood are related to higher levels of executive functioning, up to 16 years of follow-up. Accelerated decline of executive abilities observed in those with the ApoE-ε4 allele might be mitigated by higher levels of physical activity. | Keywords: | Apolipoprotein E4;Cognitive aging;Exercise | Document URI: | http://hdl.handle.net/1942/38709 | ISSN: | 0393-2990 | e-ISSN: | 1573-7284 | DOI: | 10.1007/s10654-022-00902-4 | ISI #: | 000860378500001 | Rights: | Springer Nature B.V. 2022 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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