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http://hdl.handle.net/1942/38774
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DC Field | Value | Language |
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dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | DAUW, Jeroen | - |
dc.contributor.author | MARTENS, Pieter | - |
dc.contributor.author | VERBRUGGE, Frederik | - |
dc.contributor.author | NIJST, Petra | - |
dc.contributor.author | MEEKERS, Evelyne | - |
dc.contributor.author | Tartaglia, Katrien | - |
dc.contributor.author | Chenot, Fabien | - |
dc.contributor.author | Moubayed, Samer | - |
dc.contributor.author | Dierckx, Riet | - |
dc.contributor.author | Blouard, Philippe | - |
dc.contributor.author | Troisfontaines, Pierre | - |
dc.contributor.author | Derthoo, David | - |
dc.contributor.author | Smolders, Walter | - |
dc.contributor.author | BRUCKERS, Liesbeth | - |
dc.contributor.author | Droogne, Walter | - |
dc.contributor.author | Ter Maaten, Jozine M. | - |
dc.contributor.author | Damman, Kevin | - |
dc.contributor.author | Lassus, Johan | - |
dc.contributor.author | Mebazaa, Alexandre | - |
dc.contributor.author | Filippatos, Gerasimos | - |
dc.contributor.author | Ruschitzka, Frank | - |
dc.contributor.author | DUPONT, Matthias | - |
dc.contributor.author | ADVOR Study Grp | - |
dc.date.accessioned | 2022-10-19T13:58:14Z | - |
dc.date.available | 2022-10-19T13:58:14Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-10-06T09:28:14Z | - |
dc.identifier.citation | NEW ENGLAND JOURNAL OF MEDICINE, 387 (13), p. 1185-1195 | - |
dc.identifier.issn | 0028-4793 | - |
dc.identifier.uri | http://hdl.handle.net/1942/38774 | - |
dc.description.abstract | BACKGROUND Whether acetazolamide, a carbonic anhydrase inhibitor that reduces proximal tubular sodium reabsorption, can improve the efficiency of loop diuretics, potentially leading to more and faster decongestion in patients with acute decompensated heart failure with volume overload, is unclear. METHODS In this multicenter, parallel-group, double-blind, randomized, placebo-controlled trial, we assigned patients with acute decompensated heart failure, clinical signs of volume overload (i.e., edema, pleural effusion, or ascites), and an N-terminal pro-B-type natriuretic peptide level of more than 1000 pg per milliliter or a B-type natriuretic peptide level of more than 250 pg per milliliter to receive either intravenous acetazolamide (500 mg once daily) or placebo added to standardized intravenous loop diuretics (at a dose equivalent to twice the oral maintenance dose). Randomization was stratified according to the left ventricular ejection fraction (& LE;40% or > 40%). The primary end point was successful decongestion, defined as the absence of signs of volume overload, within 3 days after randomization and without an indication for escalation of decongestive therapy. Secondary end points included a composite of death from any cause or rehospitalization for heart failure during 3 months of follow-up. Safety was also assessed. REUSLTS A total of 519 patients underwent randomization. Successful decongestion occurred in 108 of 256 patients (42.2%) in the acetazolamide group and in 79 of 259 (30.5%) in the placebo group (risk ratio, 1.46; 95% confidence interval [CI], 1.17 to 1.82; P < 0.001). Death from any cause or rehospitalization for heart failure occurred in 76 of 256 patients (29.7%) in the acetazolamide group and in 72 of 259 patients (27.8%) in the placebo group (hazard ratio, 1.07; 95% CI, 0.78 to 1.48). Acetazolamide treatment was associated with higher cumulative urine output and natriuresis, findings consistent with better diuretic efficiency. The incidence of worsening kidney function, hypokalemia, hypotension, and adverse events was similar in the two groups. CONCLUSIONS The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure resulted in a greater incidence of successful decongestion. (Funded by the Belgian Health Care Knowledge Center; ADVOR ClinicalTrials.gov number, .) | - |
dc.description.sponsorship | Belgian Health Care Knowledge Center [KCE-17001] | - |
dc.language.iso | en | - |
dc.publisher | MASSACHUSETTS MEDICAL SOC | - |
dc.rights | 2022 Massachusetts Medical Society. | - |
dc.title | Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1195 | - |
dc.identifier.issue | 13 | - |
dc.identifier.spage | 1185 | - |
dc.identifier.volume | 387 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Mullens, W (corresponding author), Ziekenhuis Oost Limburg, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
local.publisher.place | WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1056/NEJMoa2203094 | - |
dc.identifier.isi | 000861026900001 | - |
dc.contributor.orcid | Verbrugge, Frederik/0000-0003-0599-9290 | - |
dc.identifier.eissn | 1533-4406 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Mullens, Wilfried] Ziekenhuis Oost Limburg, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
local.description.affiliation | [Mullens, Wilfried; Dauw, Jeroen; Martens, Pieter; Nijst, Petra; Meekers, Evelyne; Tartaglia, Katrien; Dupont, Matthias] Ziekenhuis Oost Limburg, Genk, Limburg, Belgium. | - |
local.description.affiliation | [Mullens, Wilfried; Dauw, Jeroen; Meekers, Evelyne; Bruckers, Liesbeth] Hasselt Univ, Hasselt, Belgium. | - |
local.description.affiliation | [Verbrugge, Frederik H.] Univ Ziekenhuis Brusse, Jette, Belgium. | - |
local.description.affiliation | [Verbrugge, Frederik H.] Vrije Univ Brussel, Jette, Belgium. | - |
local.description.affiliation | [Chenot, Fabien] Grand Hop Charleroi, Charleroi, Belgium. | - |
local.description.affiliation | [Moubayed, Samer] CHU Charleroi, Charleroi, Belgium. | - |
local.description.affiliation | [Dierckx, Riet] Onze Lieve Vrouw Hosp, Aalst, Belgium. | - |
local.description.affiliation | [Blouard, Philippe] Clin St Luc, Bouge, Belgium. | - |
local.description.affiliation | [Troisfontaines, Pierre] Ctr Hosp Reg Citadelle Hosp, Liege, Belgium. | - |
local.description.affiliation | [Derthoo, David] AZ Groeninge, Kortrijk, Belgium. | - |
local.description.affiliation | [Smolders, Walter] AZ Klina, Brasschaat, Belgium. | - |
local.description.affiliation | [Droogne, Walter] Univ Hosp Leuven, Leuven, Belgium. | - |
local.description.affiliation | [Ter Maaten, Jozine M.; Damman, Kevin] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands. | - |
local.description.affiliation | [Lassus, Johan] Helsinki Univ Hosp, Heart & Lung Ctr, Dept Cardiol, Helsinki, Finland. | - |
local.description.affiliation | [Lassus, Johan] Univ Helsinki, Helsinki, Finland. | - |
local.description.affiliation | [Mebazaa, Alexandre] Univ Paris Cite, AP HP, INSERM, MASCOT Cardiovasc Markers Stressed Condit, Paris, France. | - |
local.description.affiliation | [Filippatos, Gerasimos] Natl & Kapodistrian Univ Athens, Athens, Greece. | - |
local.description.affiliation | [Filippatos, Gerasimos] Athens Univ Hosp Attikon, Athens, Greece. | - |
local.description.affiliation | [Ruschitzka, Frank] Univ Spital Zurich, Zurich, Switzerland. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2023 | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | DAUW, Jeroen | - |
item.contributor | MARTENS, Pieter | - |
item.contributor | VERBRUGGE, Frederik | - |
item.contributor | NIJST, Petra | - |
item.contributor | MEEKERS, Evelyne | - |
item.contributor | Tartaglia, Katrien | - |
item.contributor | Chenot, Fabien | - |
item.contributor | Moubayed, Samer | - |
item.contributor | Dierckx, Riet | - |
item.contributor | Blouard, Philippe | - |
item.contributor | Troisfontaines, Pierre | - |
item.contributor | Derthoo, David | - |
item.contributor | Smolders, Walter | - |
item.contributor | BRUCKERS, Liesbeth | - |
item.contributor | Droogne, Walter | - |
item.contributor | Ter Maaten, Jozine M. | - |
item.contributor | Damman, Kevin | - |
item.contributor | Lassus, Johan | - |
item.contributor | Mebazaa, Alexandre | - |
item.contributor | Filippatos, Gerasimos | - |
item.contributor | Ruschitzka, Frank | - |
item.contributor | DUPONT, Matthias | - |
item.contributor | ADVOR Study Grp | - |
item.accessRights | Open Access | - |
item.fullcitation | MULLENS, Wilfried; DAUW, Jeroen; MARTENS, Pieter; VERBRUGGE, Frederik; NIJST, Petra; MEEKERS, Evelyne; Tartaglia, Katrien; Chenot, Fabien; Moubayed, Samer; Dierckx, Riet; Blouard, Philippe; Troisfontaines, Pierre; Derthoo, David; Smolders, Walter; BRUCKERS, Liesbeth; Droogne, Walter; Ter Maaten, Jozine M.; Damman, Kevin; Lassus, Johan; Mebazaa, Alexandre; Filippatos, Gerasimos; Ruschitzka, Frank; DUPONT, Matthias & ADVOR Study Grp (2022) Acetazolamide in Acute Decompensated Heart Failure with Volume Overload. In: NEW ENGLAND JOURNAL OF MEDICINE, 387 (13), p. 1185-1195. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0028-4793 | - |
crisitem.journal.eissn | 1533-4406 | - |
Appears in Collections: | Research publications |
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plSTO.pdf | Published version | 413.39 kB | Adobe PDF | View/Open |
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