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http://hdl.handle.net/1942/38787
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DC Field | Value | Language |
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dc.contributor.author | HEHL, Melina | - |
dc.contributor.author | Swinnen, Stephan P. | - |
dc.contributor.author | VAN MALDEREN, Shanti | - |
dc.contributor.author | CUYPERS, Koen | - |
dc.date.accessioned | 2022-10-20T08:08:48Z | - |
dc.date.available | 2022-10-20T08:08:48Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-10-13T07:07:02Z | - |
dc.identifier.citation | Frontiers in Aging Neuroscience, | - |
dc.identifier.issn | 1663-4365 | - |
dc.identifier.uri | http://hdl.handle.net/1942/38787 | - |
dc.description.abstract | CITATION Hehl M, Swinnen SP, Van Malderen S and Cuypers K (2022) No evidence for a difference in lateralization and distinctiveness level of transcranial magnetic stimulation-derived cortical motor representations over the adult lifespan. This study aimed to investigate the presence and patterns of age-related differences in TMS-based measures of lateralization and distinctiveness of the cortical motor representations of two different hand muscles. In a sample of seventy-three right-handed healthy participants over the adult lifespan, the first dorsal interosseus (FDI) and abductor digiti minimi (ADM) cortical motor representations of both hemispheres were acquired using transcranial magnetic stimulation (TMS). In addition, dexterity and maximum force levels were measured. Lateralization quotients were calculated for homolog behavioral and TMS measures, whereas the distinctiveness between the FDI and ADM representation within one hemisphere was quantified by the center of gravity (CoG) distance and cosine similarity. The presence and patterns of age-related changes were examined using linear, polynomial, and piecewise linear regression. No age-related differences could be identified for the lateralization quotient of behavior or cortical motor representations of both intrinsic hand muscles. Furthermore, no evidence for a change in the distinctiveness of the FDI and ADM representation with advancing age was found. In conclusion this work showed that lateralization and distinctiveness of cortical motor representations, as determined by means of TMS-based measures, remain stable over the adult lifespan. | - |
dc.description.sponsorship | Funding This work was supported by the Research Fund KULeuven (C16/15/070), the Research Foundation Flanders grant (G039821N), the Excellence of Science grant (EOS 30446199, MEMODYN), and the Infrastructure fund from the Research Foundation Flanders [AUHL/11/01 (R-3987) and I005018N]. MH (11F6921N) and SVM (11L9322N) were funded by a fellowship grant from FWO. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. SVM was supported by the UHasselt Special Research Fund grant (BOF21INCENT15). Acknowledgments We wish to thank H. Thijs and R. Clerckx for their assistance in the statistical analysis and the automatization of data processing, respectively | - |
dc.language.iso | en | - |
dc.publisher | - | |
dc.rights | © 2022 Hehl, Swinnen, Van Malderen and Cuypers. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | - |
dc.subject.other | transcrancial magnetic stimulation (TMS) | - |
dc.subject.other | cortical motor representation | - |
dc.subject.other | aging | - |
dc.subject.other | lateralization | - |
dc.subject.other | distinctiveness | - |
dc.subject.other | dedifferentiation | - |
dc.title | No evidence for a difference in lateralization and distinctiveness level of transcranial magnetic stimulation-derived cortical motor representations over the adult lifespan | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 14 | - |
local.format.pages | 13 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.3389/fnagi.2022.971858 | - |
dc.identifier.isi | 000875832000001 | - |
dc.identifier.eissn | 1663-4365 | - |
local.provider.type | - | |
local.uhasselt.international | no | - |
item.contributor | HEHL, Melina | - |
item.contributor | Swinnen, Stephan P. | - |
item.contributor | VAN MALDEREN, Shanti | - |
item.contributor | CUYPERS, Koen | - |
item.validation | ecoom 2023 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | HEHL, Melina; Swinnen, Stephan P.; VAN MALDEREN, Shanti & CUYPERS, Koen (2022) No evidence for a difference in lateralization and distinctiveness level of transcranial magnetic stimulation-derived cortical motor representations over the adult lifespan. In: Frontiers in Aging Neuroscience,. | - |
crisitem.journal.issn | 1663-4365 | - |
crisitem.journal.eissn | 1663-4365 | - |
Appears in Collections: | Research publications |
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fnagi-14-971858.pdf | Published version | 2.83 MB | Adobe PDF | View/Open |
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