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http://hdl.handle.net/1942/38789
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DC Field | Value | Language |
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dc.contributor.author | Zalieckas, Justas | - |
dc.contributor.author | Mondragon, Ivan R. | - |
dc.contributor.author | POBEDINSKAS, Paulius | - |
dc.contributor.author | Kristoffersen, Arne S. | - |
dc.contributor.author | Mohamed-Ahmed, Samih | - |
dc.contributor.author | Gjerde, Cecilie | - |
dc.contributor.author | Hol, Paul J. | - |
dc.contributor.author | Hallan, Geir | - |
dc.contributor.author | Furnes, Ove N. | - |
dc.contributor.author | Cimpan, Mihaela Roxana | - |
dc.contributor.author | HAENEN, Ken | - |
dc.contributor.author | Holst, Bodil | - |
dc.contributor.author | Greve, Martin M. | - |
dc.date.accessioned | 2022-10-20T08:37:32Z | - |
dc.date.available | 2022-10-20T08:37:32Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-10-14T14:58:22Z | - |
dc.identifier.citation | ACS Applied Materials & Interfaces, 14 (39) , p. 44933 -44946 | - |
dc.identifier.uri | http://hdl.handle.net/1942/38789 | - |
dc.description.abstract | Polycrystalline diamond has the potential to improve the osseointegration of orthopedic implants compared to conventional materials such as titanium. However, despite the excellent biocompatibility and superior mechanical properties, the major challenge of using diamond for implants, such as those used for hip arthroplasty, is the limitation of microwave plasma chemical vapor deposition (CVD) techniques to synthesize diamond on complex-shaped objects. Here, for the first time, we demonstrate diamond growth on titanium acetabular shells using the surface wave plasma CVD method. Polycrystalline diamond coatings were synthesized at low temperatures (& SIM;400 & DEG;C) on three types of acetabular shells with different surface structures and porosities. We achieved the growth of diamond on highly porous surfaces designed to mimic the structure of the trabecular bone and improve osseointegration. Biocompatibility was investigated on nanocrystalline diamond (NCD) and ultrananocrystalline diamond (UNCD) coatings terminated either with hydrogen or oxygen. To understand the role of diamond surface topology and chemistry in the attachment and proliferation of mammalian cells, we investigated the adsorption of extracellular matrix proteins and monitored the metabolic activity of fibroblasts, osteoblasts, and bone-marrow-derived mesenchymal stem cells (MSCs). The interaction of bovine serum albumin and type I collagen with the diamond surfaces was investigated by confocal fluorescence lifetime imaging microscopy (FLIM). We found that the proliferation of osteogenic cells was better on hydrogen-terminated UNCD than on the oxygen-terminated counterpart. These findings correlated with the behavior of collagen on diamond substrates observed by FLIM. Hydrogen-terminated UNCD provided better adhesion and proliferation of osteogenic cells, compared to titanium, while the growth of fibroblasts was poorest on hydrogen-terminated NCD and MSCs behaved similarly on all tested surfaces. These results open new opportunities for application of diamond coatings on orthopedic implants to further improve bone fixation and osseointegration. | - |
dc.description.sponsorship | The Research Council of Norway is acknowledged for the support to the Norwegian Micro- and Nano-Fabrication Facility, NorFab, project number 295864 and NanoBioReal, project number 288768. Confocal imaging was performed at the Molecular Imaging Center, University of Bergen. This work was financially supported by the Methusalem NANO network. | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.rights | 2022 The Authors. Published by American Chemical Society | - |
dc.subject.other | diamond | - |
dc.subject.other | surface wave plasma | - |
dc.subject.other | orthopedic implants | - |
dc.subject.other | acetabular shell | - |
dc.subject.other | collagen | - |
dc.subject.other | albumin | - |
dc.subject.other | cell proliferation | - |
dc.title | Polycrystalline Diamond Coating on Orthopedic Implants: Realization and Role of Surface Topology and Chemistry in Adsorption of Proteins and Cell Proliferation | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 44946 | - |
dc.identifier.issue | 39 | - |
dc.identifier.spage | 44933 | - |
dc.identifier.volume | 14 | - |
local.format.pages | 14 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Zalieckas, J (corresponding author), Univ Bergen, Dept Phys & Technol, N-5007 Bergen, Norway. | - |
dc.description.notes | justas.zalieckas@uib.no | - |
local.publisher.place | 1155 16TH ST, NW, WASHINGTON, DC 20036 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | Early view | - |
dc.identifier.doi | 10.1021/acsami.2c10121 | - |
dc.identifier.pmid | 36135965 | - |
dc.identifier.isi | 000859951700001 | - |
dc.contributor.orcid | Zalieckas, Justas/0000-0002-6717-5214; Furnes, Ove/0000-0001-8223-2515; | - |
dc.contributor.orcid | Hol, Paul Johan/0000-0002-4216-7891 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Mondragon, Ivan R.; Mohamed-Ahmed, Samih; Gjerde, Cecilie; Cimpan, Mihaela Roxana] Univ Bergen, Dept Clin Dent, N-5009 Bergen, Norway. | - |
local.description.affiliation | [Pobedinskas, Paulius; Haenen, Ken] Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Pobedinskas, Paulius; Haenen, Ken] Interuniv Microelect Ctr IMEC vzw, IMOMEC, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Zalieckas, Justas; Kristoffersen, Arne S.; Holst, Bodil; Greve, Martin M.] Univ Bergen, Dept Phys & Technol, N-5007 Bergen, Norway. | - |
local.description.affiliation | [Hol, Paul J.; Hallan, Geir; Furnes, Ove N.] Haukeland Hosp, Dept Orthopaed Surg, N-5021 Bergen, Norway. | - |
local.description.affiliation | [Hol, Paul J.; Hallan, Geir; Furnes, Ove N.] Haukeland Hosp, Dept Clin Med, N-5021 Bergen, Norway. | - |
local.uhasselt.international | yes | - |
item.contributor | Zalieckas, Justas | - |
item.contributor | Mondragon, Ivan R. | - |
item.contributor | POBEDINSKAS, Paulius | - |
item.contributor | Kristoffersen, Arne S. | - |
item.contributor | Mohamed-Ahmed, Samih | - |
item.contributor | Gjerde, Cecilie | - |
item.contributor | Hol, Paul J. | - |
item.contributor | Hallan, Geir | - |
item.contributor | Furnes, Ove N. | - |
item.contributor | Cimpan, Mihaela Roxana | - |
item.contributor | HAENEN, Ken | - |
item.contributor | Holst, Bodil | - |
item.contributor | Greve, Martin M. | - |
item.validation | ecoom 2023 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | Zalieckas, Justas; Mondragon, Ivan R.; POBEDINSKAS, Paulius; Kristoffersen, Arne S.; Mohamed-Ahmed, Samih; Gjerde, Cecilie; Hol, Paul J.; Hallan, Geir; Furnes, Ove N.; Cimpan, Mihaela Roxana; HAENEN, Ken; Holst, Bodil & Greve, Martin M. (2022) Polycrystalline Diamond Coating on Orthopedic Implants: Realization and Role of Surface Topology and Chemistry in Adsorption of Proteins and Cell Proliferation. In: ACS Applied Materials & Interfaces, 14 (39) , p. 44933 -44946. | - |
crisitem.journal.issn | 1944-8244 | - |
crisitem.journal.eissn | 1944-8252 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Polycrystalline Diamond Coating on Orthopedic Implants_ Realization and Role of Surface Topology and Chemistry in Adsorption of Proteins and Cell Proliferation.pdf | Published version | 11.15 MB | Adobe PDF | View/Open |
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