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http://hdl.handle.net/1942/38793
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DC Field | Value | Language |
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dc.contributor.author | OMBELET, Willem | - |
dc.contributor.author | Van Blerkom, Jonathan | - |
dc.contributor.author | NARGUND, Geeta | - |
dc.contributor.author | Van der Auwera, Ingrid | - |
dc.contributor.author | Janssen, Mia | - |
dc.contributor.author | Dhont, Nathalie | - |
dc.contributor.author | Bosmans, Eugene | - |
dc.contributor.author | BOSHOFF, Gerhard | - |
dc.contributor.author | Vertessen, Viktor-Jan | - |
dc.contributor.author | Campo, Rudi | - |
dc.date.accessioned | 2022-10-24T06:50:29Z | - |
dc.date.available | 2022-10-24T06:50:29Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-10-14T15:43:32Z | - |
dc.identifier.citation | REPRODUCTIVE BIOMEDICINE ONLINE, 45 (3) , p. 481 -490 | - |
dc.identifier.uri | http://hdl.handle.net/1942/38793 | - |
dc.description.abstract | Research question: Can a novel closed simplified IVF culture system be used to achieve outcomes comparable to those obtained with intracytoplasmic sperm injection (ICSI) followed by conventional culturing? Design: This analysis is part of a non-inferiority prospective study comparing ICSI and a simplified culture system (SCS) for gamete fertilization in a selected group of patients. According to protocol, sibling oocytes in intact cumulus-oocyte complexes were randomly distributed between ICSI and conventional insemination in the SCS. For women, selection criteria included being under 43 years of age and at least six eggs at retrieval. An inseminating motile sperm count >= 1 million was required. The primary outcome measure was ongoing pregnancy rate (> 12 weeks) per cycle; secondary outcome measures included fertilization rate, miscarriage rate and implantation rate (ongoing pregnancy rate per embryo). Results: From January 2016 until December 2019, 653 SCS/ICSI cycles were performed yielding a total of 7915 oocytes. The fertilization rate was 61.1% and 50.4% for SCS and ICSI (P < 0.0001), respectively. The ongoing pregnancy rate was 32.0% for SCS and 36.7% for ICSI (P = 0.27). Implantation rate was 30.6% for SCS and 34.4% for ICSI (P = 0.35). The miscarriage rate was 7.5% and 6.5% for SCS and ICSI, respectively (P = 0.75). Conclusion: No difference was found in ongoing pregnancy rate, implantation rate and the miscarriage rate between SCS and ICSI in this selected patient cohort. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.rights | 2022 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. *Corresponding author. E-mail address: willem.ombelet@telenet.be (W. Ombelet). https://doi.org/10.1016/j. rbmo.2022.04.008 1472-6483/© 2022 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. Declaration: The authors report no financial or commercial conflicts of interest. | - |
dc.subject.other | Accessible IVF | - |
dc.subject.other | Assisted reproduction | - |
dc.subject.other | ICSI | - |
dc.subject.other | Infertility care | - |
dc.subject.other | Low-and middle-income countries | - |
dc.subject.other | Simplified IVF | - |
dc.title | Multiyear outcomes using sibling oocytes demonstrates safety and efficacy of a simplified culture system consistent with use in a low-cost IVF setting | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 490 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 481 | - |
dc.identifier.volume | 45 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Ombelet, W (corresponding author), ZOL, Genk Inst Fertil Technol, Dept Obstet & Gynaecol, Campus St Jan, Genk, Belgium.; Ombelet, W (corresponding author), Hasselt Univ, Fac Med & Life Sci, Agoralaan, B-3590 Diepenbeek, Belgium. | - |
dc.description.notes | willem.ombelet@telenet.be | - |
local.publisher.place | THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.rbmo.2022.04.008 | - |
dc.identifier.pmid | 36064261 | - |
dc.identifier.isi | 000862853900008 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Ombelet, Willem; Van der Auwera, Ingrid; Janssen, Mia; Dhont, Nathalie; Bosmans, Eugene; Vertessen, Viktor-Jan; Campo, Rudi] ZOL, Genk Inst Fertil Technol, Dept Obstet & Gynaecol, Campus St Jan, Genk, Belgium. | - |
local.description.affiliation | [Ombelet, Willem] Hasselt Univ, Fac Med & Life Sci, Agoralaan, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Van Blerkom, Jonathan] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO USA. | - |
local.description.affiliation | [Nargund, Geeta] St Georges Univ Hosp, London & Create Fertil, London, England. | - |
local.description.affiliation | [Boshoff, Gerhard] Univ Pretoria, Dept Obstet & Gynaecol, Arcadia Pretoria, South Africa. | - |
local.uhasselt.international | yes | - |
item.fullcitation | OMBELET, Willem; Van Blerkom, Jonathan; NARGUND, Geeta; Van der Auwera, Ingrid; Janssen, Mia; Dhont, Nathalie; Bosmans, Eugene; BOSHOFF, Gerhard; Vertessen, Viktor-Jan & Campo, Rudi (2022) Multiyear outcomes using sibling oocytes demonstrates safety and efficacy of a simplified culture system consistent with use in a low-cost IVF setting. In: REPRODUCTIVE BIOMEDICINE ONLINE, 45 (3) , p. 481 -490. | - |
item.validation | ecoom 2023 | - |
item.contributor | OMBELET, Willem | - |
item.contributor | Van Blerkom, Jonathan | - |
item.contributor | NARGUND, Geeta | - |
item.contributor | Van der Auwera, Ingrid | - |
item.contributor | Janssen, Mia | - |
item.contributor | Dhont, Nathalie | - |
item.contributor | Bosmans, Eugene | - |
item.contributor | BOSHOFF, Gerhard | - |
item.contributor | Vertessen, Viktor-Jan | - |
item.contributor | Campo, Rudi | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 1472-6483 | - |
crisitem.journal.eissn | 1472-6491 | - |
Appears in Collections: | Research publications |
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Multiyear outcomes using sibling oocytes demonstrates safety and efficacy of a simplified culture system consistent with use in a low-cost IVF setting.pdf Restricted Access | Published version | 1.04 MB | Adobe PDF | View/Open Request a copy |
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