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http://hdl.handle.net/1942/38794
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DC Field | Value | Language |
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dc.contributor.author | SPRANGERS, Ben | - |
dc.contributor.author | Leaf, David E. | - |
dc.contributor.author | Porta, Camillo | - |
dc.contributor.author | Soler, Maria Jose | - |
dc.contributor.author | Perazella, Mark A. | - |
dc.date.accessioned | 2022-10-24T07:01:44Z | - |
dc.date.available | 2022-10-24T07:01:44Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-10-14T15:41:39Z | - |
dc.identifier.citation | Nature Reviews Nephrology, 18 (12), p. 794-805 | - |
dc.identifier.uri | http://hdl.handle.net/1942/38794 | - |
dc.description.abstract | Immune checkpoint inhibitors are increasingly used as anti-cancer treatments; however, their use can be associated with the development of immune-related adverse events, including acute kidney injury. This Review describes the symptoms, biochemical signs and possible underlying mechanisms of immune checkpoint inhibitor-associated acute kidney injury, and proposes an approach to its diagnosis and management. Since their introduction into clinical practice a decade ago, immune checkpoint inhibitors (ICIs) have had an overwhelming impact on cancer treatment. Use of these agents in oncology continues to grow; however, the increased use of these agents has been associated with a parallel increase in ICI-associated immune-related adverse events, which can affect virtually any organ, including the kidneys. ICI-associated acute kidney injury (ICI-AKI) occurs in 2-5% of patients treated with ICIs. Its occurrence can have important consequences, including the temporary or permanent discontinuation of ICIs or other concomitant anticancer therapies and the need for prolonged treatment with corticosteroids. Various mechanisms have been proposed to underlie the development of ICI-AKI, including loss of tolerance to self-antigens, reactivation of drug-specific effector T cells, and the production of kidney-specific autoantibodies. ICI-AKI most commonly manifests as acute tubulo-interstitial nephritis on kidney biopsy and generally shows a favourable response to early initiation of corticosteroids, with complete or partial remission achieved in most patients. The evaluation of patients with suspected ICI-AKI requires careful diagnostic work-up and kidney biopsy for patients with moderate-to-severe ICI-AKI to ensure accurate diagnosis and inform appropriate treatment. | - |
dc.description.sponsorship | B.S. is a senior clinical investigator of The Research Foundation Flanders (F.W.O. 1842919N) and receives funding from the Foundation against Cancer (Stichting tegen Kanker; C/2020/1380). D.E.L. is funded by National Institutes of Health grants R01HL144566, R01DK125786 and R01DK126685. M.J.S. is funded by Fondo de Investigación Sanitaria-FEDER, ISCIII, PI17/00257, REDINREN, RD16/0009/0030 and EIN2020-112338. We would like to thank Albert Herelixka, University Hospitals Leuven, Belgium, for drawing the figures included in the original submission of this manuscript. | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.rights | Springer Nature Limited 2022 | - |
dc.title | Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 805 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 794 | - |
dc.identifier.volume | 18 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Sprangers, B (corresponding author), Ziekenhuis Oost Limburg, Div Nephrol, Genk, Belgium.; Sprangers, B (corresponding author), UHasselt, Biomed Res Inst, Dept Immunol & Infect, Diepenbeek, Belgium. | - |
dc.description.notes | Ben.Sprangers@zol.be | - |
local.publisher.place | HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1038/s41581-022-00630-8 | - |
dc.identifier.pmid | 36168055 | - |
dc.identifier.isi | 000860372800001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Sprangers, Ben] Ziekenhuis Oost Limburg, Div Nephrol, Genk, Belgium. | - |
local.description.affiliation | [Sprangers, Ben] UHasselt, Biomed Res Inst, Dept Immunol & Infect, Diepenbeek, Belgium. | - |
local.description.affiliation | [Leaf, David E.] Brigham & Womens Hosp, Div Renal Med, Boston, MA USA. | - |
local.description.affiliation | [Porta, Camillo] Azienda Osped Univ Corsorziale Policlin, Div Med Oncol, Bari, Italy. | - |
local.description.affiliation | [Porta, Camillo] Univ Bari Aldo Moro, Interdisciplinary Dept Med, Oncol, Bari, Italy. | - |
local.description.affiliation | [Soler, Maria Jose] Vall hebron Inst Recerca VHIR, Nephrol Res Grp, Barcelona, Spain. | - |
local.description.affiliation | [Soler, Maria Jose] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Dept Nephrol, Barcelona, Spain. | - |
local.description.affiliation | [Perazella, Mark A.] Yale Univ, Nephrol Sect, Sch Med, New Haven, CT USA. | - |
local.description.affiliation | [Perazella, Mark A.] Vet Affairs Med Ctr, West Haven, CT USA. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2023 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | SPRANGERS, Ben; Leaf, David E.; Porta, Camillo; Soler, Maria Jose & Perazella, Mark A. (2022) Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury. In: Nature Reviews Nephrology, 18 (12), p. 794-805. | - |
item.accessRights | Restricted Access | - |
item.contributor | SPRANGERS, Ben | - |
item.contributor | Leaf, David E. | - |
item.contributor | Porta, Camillo | - |
item.contributor | Soler, Maria Jose | - |
item.contributor | Perazella, Mark A. | - |
crisitem.journal.issn | 1759-5061 | - |
crisitem.journal.eissn | 1759-507X | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury.pdf Restricted Access | Published version | 2.15 MB | Adobe PDF | View/Open Request a copy |
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