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http://hdl.handle.net/1942/38798
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DC Field | Value | Language |
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dc.contributor.author | OMBELET, Willem | - |
dc.contributor.author | Van Blerkom, Jonathan | - |
dc.contributor.author | NARGUND, Geeta | - |
dc.contributor.author | Janssen, Mia | - |
dc.contributor.author | Jacobs, Petra | - |
dc.contributor.author | Auwera, Ingrid Van der | - |
dc.contributor.author | Dhont, Nathalie | - |
dc.contributor.author | Bosmans, Eugene | - |
dc.contributor.author | Vertessen, Viktor-Jan | - |
dc.contributor.author | Campo, Rudi | - |
dc.date.accessioned | 2022-10-24T09:34:17Z | - |
dc.date.available | 2022-10-24T09:34:17Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-10-14T15:42:38Z | - |
dc.identifier.citation | REPRODUCTIVE BIOMEDICINE ONLINE, 45 (3) , p. 574 -582 | - |
dc.identifier.uri | http://hdl.handle.net/1942/38798 | - |
dc.description.abstract | Research question: Is there a difference in perinatal outcome in the same patient cohort for babies conceived following randomization of sibling oocytes allocated to a simplified IVF culture system (SCS) or intracytoplasmic sperm injection (ICSI) followed by conventional culturing? Design: The study compared the perinatal outcomes of 367 babies born from 1 January 2013 until 31 December 2020 after using split SCS and ICSI insemination of sibling oocytes in a selected group of normo-responsive women, excluding cases of severe male infertility. Primary outcome measures were preterm birth (PTB; <37 weeks' gestation), low birthweight (LBW; <2.5 kg) and small for gestational age (SGA) as a primary outcome parameter while secondary outcome measures included mean birthweight, mean gestational age, extreme prematurity (<32 weeks), very low birthweight (<1.5 kg), perinatal mortality, multiple pregnancy and Caesarean section rate. Results: A total of 105 and 103 singleton babies were born after fresh embryo transfer (FRET) and 71 and 50 singletons after frozen embryo transfer (FET) in the SCS and ICSI groups, respectively. For babies born after FRET, the LBW rate was 2.9% (3/105) for SCS and 78% (8/103) for ICSI (P = 0.10). LBW occurred in 4.2% (3/71) and 0% (0/50) of babies born after the transfer of cryopreserved-thawed SCS and ICSI embryos, respectively (P = 0.14). The rate of PTB was 3.8% and 6.8% for SCS and ICSI in FRET cycles (P = 0.33), and 8.5% and 6.0% for SCS and ICSI in FET cycles (P = 0.62). One congenital malformation was found in the SCS FET group. Conclusion: There was no difference in perinatal outcome for singleton and twin babies born after SCS and ICSI. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.rights | 2022 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. *Corresponding author. E-mail address: willem.ombelet@telenet.be (W. Ombelet). https://doi.org/10.1016/j. rbmo.2022.04.009 1472-6483/© 2022 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. Declaration: The authors report no financial or commercial conflicts of interest. | - |
dc.subject.other | Assisted reproduction | - |
dc.subject.other | Intracytoplasmic sperm injection (ICSI) | - |
dc.subject.other | Low birthweight | - |
dc.subject.other | Perinatal outcome | - |
dc.subject.other | Prematurity | - |
dc.subject.other | Simplified IVF | - |
dc.title | Perinatal outcome of babies born after using a simplified IVF culture system versus ICSI with sibling oocytes: a prospective cohort study | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 582 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 574 | - |
dc.identifier.volume | 45 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Ombelet, W (corresponding author), ZOL, Genk Inst Fertil Technol, Dept Obstet & Gynaecol, Campus St Jan, Genk, Belgium.; Ombelet, W (corresponding author), Hasselt Univ, Fac Med & Life Sci, Agoralaan, Diepenbeek, Belgium. | - |
dc.description.notes | willem.ombelet@telenet.be | - |
local.publisher.place | THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.rbmo.2022.04.009 | - |
dc.identifier.pmid | 35760665 | - |
dc.identifier.isi | 000862853900015 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Ombelet, Willem; Janssen, Mia; Jacobs, Petra; Auwera, Ingrid Van der; Dhont, Nathalie; Bosmans, Eugene; Vertessen, Viktor-Jan; Campo, Rudi] ZOL, Genk Inst Fertil Technol, Dept Obstet & Gynaecol, Campus St Jan, Genk, Belgium. | - |
local.description.affiliation | [Ombelet, Willem] Hasselt Univ, Fac Med & Life Sci, Agoralaan, Diepenbeek, Belgium. | - |
local.description.affiliation | [Van Blerkom, Jonathan] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO USA. | - |
local.description.affiliation | [Nargund, Geeta] St Georges Univ Hosp, London & Create Fertil UK, London, England. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2023 | - |
item.accessRights | Restricted Access | - |
item.fullcitation | OMBELET, Willem; Van Blerkom, Jonathan; NARGUND, Geeta; Janssen, Mia; Jacobs, Petra; Auwera, Ingrid Van der; Dhont, Nathalie; Bosmans, Eugene; Vertessen, Viktor-Jan & Campo, Rudi (2022) Perinatal outcome of babies born after using a simplified IVF culture system versus ICSI with sibling oocytes: a prospective cohort study. In: REPRODUCTIVE BIOMEDICINE ONLINE, 45 (3) , p. 574 -582. | - |
item.fulltext | With Fulltext | - |
item.contributor | OMBELET, Willem | - |
item.contributor | Van Blerkom, Jonathan | - |
item.contributor | NARGUND, Geeta | - |
item.contributor | Janssen, Mia | - |
item.contributor | Jacobs, Petra | - |
item.contributor | Auwera, Ingrid Van der | - |
item.contributor | Dhont, Nathalie | - |
item.contributor | Bosmans, Eugene | - |
item.contributor | Vertessen, Viktor-Jan | - |
item.contributor | Campo, Rudi | - |
crisitem.journal.issn | 1472-6483 | - |
crisitem.journal.eissn | 1472-6491 | - |
Appears in Collections: | Research publications |
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Perinatal outcome of babies born after using a simplified IVF culture system versus ICSI with sibling oocytes_ a prospective cohort study.pdf Restricted Access | Published version | 368.86 kB | Adobe PDF | View/Open Request a copy |
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