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http://hdl.handle.net/1942/38800
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DC Field | Value | Language |
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dc.contributor.author | Pinxterhuis, Tineke H. | - |
dc.contributor.author | Ploumen, Eline H. | - |
dc.contributor.author | Zocca, Paolo | - |
dc.contributor.author | Doggen, Carine J. M. | - |
dc.contributor.author | Schotborgh, Carl E. | - |
dc.contributor.author | Anthonio, Rutger L. | - |
dc.contributor.author | Roguin, Ariel | - |
dc.contributor.author | Danse, Peter W. | - |
dc.contributor.author | BENIT, Edouard | - |
dc.contributor.author | Aminian, Adel | - |
dc.contributor.author | Stoel, Martin G. | - |
dc.contributor.author | Linssen, Gerard C. M. | - |
dc.contributor.author | Geelkerken, Robert H. | - |
dc.contributor.author | von Birgelen, Clemens | - |
dc.date.accessioned | 2022-10-24T10:10:16Z | - |
dc.date.available | 2022-10-24T10:10:16Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-10-14T15:27:52Z | - |
dc.identifier.citation | ATHEROSCLEROSIS, 355 , p. 52 -59 | - |
dc.identifier.uri | http://hdl.handle.net/1942/38800 | - |
dc.description.abstract | Background and aims: A considerable number of patients who undergo percutaneous coronary intervention (PCI) also have peripheral arterial disease (PAD) - a signal of more advanced atherosclerosis. After bare metal and early-generation drug-eluting coronary stent implantation, PAD patients showed inferior outcome. As stents and medical treatment were further improved, we aimed to assess the impact of PAD on outcome of PCI with contemporary new-generation stents. Methods: We analyzed 3-year pooled patient-level data from 4 large-scale randomized new-generation stent trials to compare all-comer patients with and without (core lab-verified) history of symptomatic PAD, defined as obstructive lesions in peripheral locations including lower and upper extremities, carotid, vertebral, mesenteric and renal arteries. Main endpoint was target vessel failure: cardiac death, target vessel-related myocardial infarction, or clinically indicated target vessel revascularization. Results: Of all 9204 patients, 695 (7.6%) had a history of symptomatic PAD. They were older and had more often diabetes, renal failure, hypertension, hypercholesterolemia, and prior stroke. PAD was an independent risk factor for target vessel failure (adjusted-HR:1.42, 95%-CI:1.12-1.73, p = 0.001). Target vessel revascularization (adjusted-HR:1.37, 95%-CI:1.04-1.80, p = 0.026), death (adjusted-HR:1.52, 95%-CI:1.17-1.99, p = 0.002), and major adverse cardiovascular event risks (adjusted-HR:1.36, 95%-CI:1.13-1.64, p = 0.001) were also substantially higher. Conclusions: A history of symptomatic PAD still allows to simply identify patients with increased risk of unfavorable clinical outcome after PCI, including a higher risk of repeated coronary revascularization, despite using contemporary stents. In clinical practice, this knowledge about higher event risks of PAD patients is helpful both during Heart Team discussions and when informing patients about the procedural risk. | - |
dc.description.sponsorship | The original randomized clinical trials were funded by Abbott Vascular, Biotronik, Boston Scientific, and Medtronic. The present study received no additional financial support. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.rights | 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | - |
dc.subject.other | Coronary artery disease | - |
dc.subject.other | Percutaneous coronary intervention | - |
dc.subject.other | Drug-eluting stent | - |
dc.subject.other | Peripheral arterial disease | - |
dc.title | Outcome after percutaneous coronary intervention with contemporary stents in patients with concomitant peripheral arterial disease: A patient-level pooled analysis of four randomized trials | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 59 | - |
dc.identifier.spage | 52 | - |
dc.identifier.volume | 355 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | von Birgelen, C (corresponding author), Med Spectrum Twente, Dept Cardiol A25, Thoraxctr Twente, Koningspl 1, NL-7512 KZ Enschede, Netherlands. | - |
dc.description.notes | c.vonbirgelen@mst.nl | - |
local.publisher.place | ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, | - |
local.publisher.place | IRELAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2022.05.002 | - |
dc.identifier.pmid | 35641327 | - |
dc.identifier.isi | 000853696401363 | - |
dc.contributor.orcid | Pinxterhuis, Tineke/0000-0002-9050-8742 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Pinxterhuis, Tineke H.; Ploumen, Eline H.; Zocca, Paolo; Stoel, Martin G.; von Birgelen, Clemens] Thoraxctr Twente, Dept Cardiol, Med Spectrum Twente, Enschede, Netherlands. | - |
local.description.affiliation | [Pinxterhuis, Tineke H.; Ploumen, Eline H.; Doggen, Carine J. M.; von Birgelen, Clemens] Univ Twente, Fac BMS, Tech Med Ctr, Dept Hlth Technol & Serv Res, Enschede, Netherlands. | - |
local.description.affiliation | [Schotborgh, Carl E.] Haga Hosp, Dept Cardiol, The Hague, Netherlands. | - |
local.description.affiliation | [Anthonio, Rutger L.] Scheper Hosp, Dept Cardiol, Treant Zorggrp, Emmen, Netherlands. | - |
local.description.affiliation | [Roguin, Ariel] Israel Inst Technol, Hillel Yaffe Med Ctr, Hadera & B Rappaport Fac Med, Dept Cardiol, Haifa, Israel. | - |
local.description.affiliation | [Danse, Peter W.] Rijnstate Hosp, Dept Cardiol, Arnhem, Netherlands. | - |
local.description.affiliation | [Benit, Edouard] Jessa Hosp, Dept Cardiol, Hasselt, Belgium. | - |
local.description.affiliation | [Aminian, Adel] Ctr Hosp Univ Charleroi, Dept Cardiol, Charleroi, Belgium. | - |
local.description.affiliation | [Linssen, Gerard C. M.] Ziekenhuisgrp Twente, Dept Cardiol, Almelo Hengelo, Netherlands. | - |
local.description.affiliation | [Geelkerken, Robert H.] Med Spectrum Twente, Dept Vasc Surg, Enschede, Netherlands. | - |
local.description.affiliation | [Geelkerken, Robert H.] Univ Twente, Fac Sci & Technol, Tech Med Ctr, Dept Multimodal Med Imaging M31 Grp, Enschede, Netherlands. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | Pinxterhuis, Tineke H.; Ploumen, Eline H.; Zocca, Paolo; Doggen, Carine J. M.; Schotborgh, Carl E.; Anthonio, Rutger L.; Roguin, Ariel; Danse, Peter W.; BENIT, Edouard; Aminian, Adel; Stoel, Martin G.; Linssen, Gerard C. M.; Geelkerken, Robert H. & von Birgelen, Clemens (2022) Outcome after percutaneous coronary intervention with contemporary stents in patients with concomitant peripheral arterial disease: A patient-level pooled analysis of four randomized trials. In: ATHEROSCLEROSIS, 355 , p. 52 -59. | - |
item.contributor | Pinxterhuis, Tineke H. | - |
item.contributor | Ploumen, Eline H. | - |
item.contributor | Zocca, Paolo | - |
item.contributor | Doggen, Carine J. M. | - |
item.contributor | Schotborgh, Carl E. | - |
item.contributor | Anthonio, Rutger L. | - |
item.contributor | Roguin, Ariel | - |
item.contributor | Danse, Peter W. | - |
item.contributor | BENIT, Edouard | - |
item.contributor | Aminian, Adel | - |
item.contributor | Stoel, Martin G. | - |
item.contributor | Linssen, Gerard C. M. | - |
item.contributor | Geelkerken, Robert H. | - |
item.contributor | von Birgelen, Clemens | - |
crisitem.journal.issn | 0021-9150 | - |
crisitem.journal.eissn | 1879-1484 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Outcome after percutaneous coronary intervention with contemporary stents in patients with concomitant peripheral arterial disease_ A patient-level pooled analysis of four randomized trials.pdf | Published version | 1.97 MB | Adobe PDF | View/Open |
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