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http://hdl.handle.net/1942/38810
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DC Field | Value | Language |
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dc.contributor.author | NIESTE, Ine | - |
dc.contributor.author | FRANSSEN, Wouter | - |
dc.contributor.author | Duvivier, Bernard M. F. M. | - |
dc.contributor.author | SPAAS, Jan | - |
dc.contributor.author | Savelberg, Hans H. C. M. | - |
dc.contributor.author | OP 'T EIJNDE, Bert | - |
dc.date.accessioned | 2022-10-25T07:50:40Z | - |
dc.date.available | 2022-10-25T07:50:40Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-10-20T11:34:30Z | - |
dc.identifier.citation | DISABILITY AND REHABILITATION, | - |
dc.identifier.uri | http://hdl.handle.net/1942/38810 | - |
dc.description.abstract | Purpose Persons with Multiple Sclerosis (PwMS) are physically inactive and spend more time in sedentary behaviours than healthy persons, which increases the risk of developing cardiometabolic diseases. In this randomised crossover study, the cardiometabolic health effects of replacing sitting with light-intensity physical activity (LIPA) and exercise (EX) were investigated. Materials and methods Twenty-eight mildly disabled PwMS performed four 4-day activity regimens in free-living conditions; CONTROL (habitual activity), SIT, LIPA, and EX. Plasma glucose and insulin (oral glucose tolerance test), plasma lipids, inflammation, resting heart rate, blood pressure, body weight, and perceived exertion were measured (clinical-trials.gov: NCT03919058). Results CONTROL: 9.7 h sitting/day, SIT: 13.3 h sitting/day, LIPA: 8.3 h sitting, 4.7 h standing, and 2.7 h light-intensity walking/day, and EX: 11.6 h sitting/day with 1.3 h vigorous-intensity cycling. Compared to SIT, improvements (p < 0.001) after LIPA and EX were found for insulin total area under the curve (-17 019 +/- 5708 and -23 303 +/- 7953 pmol/L*min), insulin sensitivity (Matsuda index +1.8 +/- 0.3 and +1.9 +/- 0.4) and blood lipids (triglycerides: -0.4 +/- 0.1 and -0.5 +/- 0.1 mmol/L; non-high-density lipoprotein cholesterol: -0.3 +/- 0.1 and -0.5 +/- 0.1 mmol/L), with no difference between LIPA and EX. Perceived exertion was higher after EX compared to LIPA (Borg score [6-20]: +2.6 +/- 3.3, p = 0.002). Conclusion Replacing sitting with LIPA throughout the day exerts similar cardiometabolic health effects as a vigorous-intensity exercise in PwMS. | - |
dc.description.sponsorship | This work was supported by the Flemish Fund for Scientific Research (FWO Vlaanderen; 11E9221N). The funding source was not involved in the preparation of the article. We would like to thank all study participants and acknowledge M. Scherrenberg for the interpretation of the electrocardiograms. | - |
dc.language.iso | English | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.rights | 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. | - |
dc.subject.other | Sedentary behaviour | - |
dc.subject.other | light-intensity physical activity | - |
dc.subject.other | structured exercise | - |
dc.subject.other | cardiometabolic health | - |
dc.subject.other | multiple sclerosis | - |
dc.title | Replacing sitting with light-intensity physical activity throughout the day versus 1 bout of vigorous-intensity exercise: similar cardiometabolic health effects in multiple sclerosis. A randomised cross-over study | - |
dc.type | Journal Contribution | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Nieste, I (corresponding author), Hasselt Univ, Fac Med & Life Sci, Bldg A, B-3590 Diepenbeek, Belgium. | - |
dc.description.notes | Ine.nieste@uhasselt.be | - |
local.publisher.place | 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | Early view | - |
dc.identifier.doi | 10.1080/09638288.2022.2122601 | - |
dc.identifier.pmid | 36190113 | - |
dc.identifier.isi | 000863716500001 | - |
dc.contributor.orcid | SPAAS, Jan/0000-0002-4953-2505; Franssen, Wouter/0000-0001-6084-5337; | - |
dc.contributor.orcid | Nieste, Ine/0000-0002-0164-9026 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Nieste, Ine; Franssen, Wouter M. A.; Spaas, Jan; Eijnde, Bert O.] Hasselt Univ, Fac Med & Life Sci, Sports Med Res Ctr, Biomed Res Inst,SMRC,BIOMED, Hasselt, Belgium. | - |
local.description.affiliation | [Nieste, Ine; Franssen, Wouter M. A.; Savelberg, Hans H. C. M.] Maastricht Univ, Fac Hlth Med & Life Sci, Sch Nutr & Translat Res Maastricht, Dept Nutr & Movement Sci,NUTRIM, Maastricht, Netherlands. | - |
local.description.affiliation | [Nieste, Ine; Spaas, Jan; Eijnde, Bert O.] Univ MS Ctr UMSC Hasselt Pelt, Hasselt, Belgium. | - |
local.description.affiliation | [Franssen, Wouter M. A.] Hasselt Univ, Fac Rehabil Sci, REVAL Rehabil Res Ctr, Hasselt, Belgium. | - |
local.description.affiliation | [Duvivier, Bernard M. F. M.] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Leuven, Belgium. | - |
local.description.affiliation | [Spaas, Jan] Univ Ghent, Fac Med & Hlth Sci, Dept Movement & Sports Sci, Ghent, Belgium. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2023 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | NIESTE, Ine; FRANSSEN, Wouter; Duvivier, Bernard M. F. M.; SPAAS, Jan; Savelberg, Hans H. C. M. & OP 'T EIJNDE, Bert (2022) Replacing sitting with light-intensity physical activity throughout the day versus 1 bout of vigorous-intensity exercise: similar cardiometabolic health effects in multiple sclerosis. A randomised cross-over study. In: DISABILITY AND REHABILITATION,. | - |
item.accessRights | Open Access | - |
item.contributor | NIESTE, Ine | - |
item.contributor | FRANSSEN, Wouter | - |
item.contributor | Duvivier, Bernard M. F. M. | - |
item.contributor | SPAAS, Jan | - |
item.contributor | Savelberg, Hans H. C. M. | - |
item.contributor | OP 'T EIJNDE, Bert | - |
crisitem.journal.issn | 0963-8288 | - |
crisitem.journal.eissn | 1464-5165 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Replacing sitting with light-intensity physical activity throughout the day versus 1 bout of vigorou.pdf | Published version | 2.02 MB | Adobe PDF | View/Open |
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