Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/38830
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Asnong, Anne | - |
dc.contributor.author | D'Hoore, Andre | - |
dc.contributor.author | Van Kampen, Marijke | - |
dc.contributor.author | Wolthuis, Albert | - |
dc.contributor.author | Van Molhem, Yves | - |
dc.contributor.author | Van Geluwe, Bart | - |
dc.contributor.author | Devoogdt, Nele | - |
dc.contributor.author | De Groef, An | - |
dc.contributor.author | Fajardo, Ipek Guler Caamano | - |
dc.contributor.author | GULER CAAMANO FAJARDO, Ipek | - |
dc.date.accessioned | 2022-11-07T07:53:58Z | - |
dc.date.available | 2022-11-07T07:53:58Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-10-27T15:26:26Z | - |
dc.identifier.citation | ANNALS OF SURGERY, 276 (5) , p. 761 -768 | - |
dc.identifier.uri | http://hdl.handle.net/1942/38830 | - |
dc.description.abstract | Background and Objective: Total mesorectal excision (TME) for rectal cancer (RC) often results in significant bowel symptoms, commonly known as low anterior resection syndrome (LARS). Although pelvic floor muscle training (PFMT) is recommended in noncancer populations for treating bowel symptoms, this has been scarcely investigated in RC patients. The objective was to investigate PFMT effectiveness on LARS in patients after TME for RC. Methods: A multicenter, single-blind prospective randomized controlled trial comparing PFMT (intervention; n=50) versus no PFMT (control; n=54) 1 month following TME/stoma closure was performed. The primary endpoint was the proportion of participants with an improvement in the LARS category at 4 months. Secondary outcomes were: continuous LARS scores, ColoRectal Functioning Outcome scores, Numeric Rating Scale scores, stool diary items, and Short Form 12 scores; all assessed at 1, 4, 6, and 12 months. Results: The proportion of participants with an improvement in LARS category was statistically higher after PFMT compared with controls at 4 months (38.3% vs 19.6%; P=0.0415) and 6 months (47.8% vs 21.3%; P=0.0091), but no longer at 12 months (40.0% vs 34.9%; P=0.3897). Following secondary outcomes were significantly lower at 4 months: LARS scores (continuous, P=0.0496), ColoRectal Functioning Outcome scores (P=0.0369) and frequency of bowel movements (P=0.0277), solid stool leakage (day, P=0.0241; night, P=0.0496) and the number of clusters (P=0.0369), derived from the stool diary. No significant differences were found for the Numeric Rating Scale/quality of life scores. Conclusions: PFMT for bowel symptoms after TME resulted in lower proportions and faster recovery of bowel symptoms up to 6 months after surgery/stoma closure, justifying PFMT as an early, first-line treatment option for bowel symptoms after RC. | - |
dc.description.sponsorship | The authors are grateful to the trial participants and thank all participating centers and collaborating physiotherapists (MW, LDW, LV, RVH) of this trial for their contributions. They also thank Kim Sterckx, Hilde Lemkens, and Lynn Debrun especially, for all of their contributions. | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.rights | 2022 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. | - |
dc.subject.other | bowel symptoms | - |
dc.subject.other | low anterior resection syndrome | - |
dc.subject.other | pelvic floor muscle training | - |
dc.subject.other | randomized controlled trial | - |
dc.subject.other | rectal cancer | - |
dc.title | The Role of Pelvic Floor Muscle Training on Low Anterior Resection Syndrome A Multicenter Randomized Controlled Trial | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 768 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 761 | - |
dc.identifier.volume | 276 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Geraerts, I (corresponding author), KU Leuven Univ Leuven, Dept Rehabil Sci, Leuven, Belgium. | - |
dc.description.notes | inge.geraerts@kuleuven.be | - |
local.publisher.place | TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1097/SLA.0000000000005632 | - |
dc.identifier.pmid | 35894434 | - |
dc.identifier.isi | 000864836700068 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Asnong, Anne; Van Kampen, Marijke; Devoogdt, Nele; De Groef, An; Geraerts, Inge] KU Leuven Univ Leuven, Dept Rehabil Sci, Leuven, Belgium. | - |
local.description.affiliation | [D'Hoore, Andre; Wolthuis, Albert] Univ Hosp Gasthuisberg Leuven, Dept Abdominal Surg, Leuven, Belgium. | - |
local.description.affiliation | [D'Hoore, Andre; Wolthuis, Albert] KU Leuven Univ Leuven, Leuven, Belgium. | - |
local.description.affiliation | [Van Molhem, Yves] Onze Lieve Vrouw Hosp, Dept Abdominal Surg, Aalst Asse Ninove, Belgium. | - |
local.description.affiliation | [Van Geluwe, Bart] AZ Groeninge, Dept Abdominal Surg, Kortrijk, Belgium. | - |
local.description.affiliation | [Devoogdt, Nele] Univ Hosp Leuven, Ctr Lymphedema, Leuven, Belgium. | - |
local.description.affiliation | [De Groef, An] Univ Antwerp, Dept Rehabil Sci, Antwerp, Belgium. | - |
local.description.affiliation | [De Groef, An] Int Res Grp Pain Mot, Brussels, Belgium. | - |
local.description.affiliation | [Fajardo, Ipek Guler Caamano] Katholieke Univ Leuven, Interuniv Ctr Biostat & Stat Bioinformat, Leuven, Belgium. | - |
local.description.affiliation | [Fajardo, Ipek Guler Caamano] Hasselt Univ, Leuven, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2023 | - |
item.accessRights | Open Access | - |
item.fullcitation | Asnong, Anne; D'Hoore, Andre; Van Kampen, Marijke; Wolthuis, Albert; Van Molhem, Yves; Van Geluwe, Bart; Devoogdt, Nele; De Groef, An; Fajardo, Ipek Guler Caamano & GULER CAAMANO FAJARDO, Ipek (2022) The Role of Pelvic Floor Muscle Training on Low Anterior Resection Syndrome A Multicenter Randomized Controlled Trial. In: ANNALS OF SURGERY, 276 (5) , p. 761 -768. | - |
item.contributor | Asnong, Anne | - |
item.contributor | D'Hoore, Andre | - |
item.contributor | Van Kampen, Marijke | - |
item.contributor | Wolthuis, Albert | - |
item.contributor | Van Molhem, Yves | - |
item.contributor | Van Geluwe, Bart | - |
item.contributor | Devoogdt, Nele | - |
item.contributor | De Groef, An | - |
item.contributor | Fajardo, Ipek Guler Caamano | - |
item.contributor | GULER CAAMANO FAJARDO, Ipek | - |
crisitem.journal.issn | 0003-4932 | - |
crisitem.journal.eissn | 1528-1140 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
untitled.pdf | Published version | 245.81 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.