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http://hdl.handle.net/1942/3885
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DC Field | Value | Language |
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dc.contributor.author | HASHIM, GA | - |
dc.contributor.author | YING, C | - |
dc.contributor.author | VANDENBERG-LOONEN, E | - |
dc.contributor.author | MEDAER, Rob | - |
dc.contributor.author | RAUS, Jef | - |
dc.contributor.author | ZHANG, JINGWU | - |
dc.date.accessioned | 2007-11-29T15:19:27Z | - |
dc.date.available | 2007-11-29T15:19:27Z | - |
dc.date.issued | 1992 | - |
dc.identifier.citation | ANNALS OF NEUROLOGY, 32(3). p. 330-338 | - |
dc.identifier.issn | 0364-5134 | - |
dc.identifier.uri | http://hdl.handle.net/1942/3885 | - |
dc.description.abstract | A panel of 90 myelin basic protein (MBP)-specific T-cell lines were derived from peripheral blood of eight with multiple sclerosis and four normal subjects. The precursor frequency of MBP-reactive T cells in peripheral blood mononuclear cells ranged from 10(-7) to 9 X 10(-7) (mean, 6.7 x 10(-7)) in the group of patients with multiple sclerosis and from 0.5 x 10(-7) to 9.8 X 10(-7) (mean, 5.6 x 10(-7)) in the control subjects. This difference between the two groups was not statistically significant (p > 0.1). These T-cell lines expressed exclusively CD3+CD4+CD8- phenotypes and were restricted predominantly by HLA-DR molecules. When tested with fragments and synthetic peptides of human MBP, these MBP-specific T-cell lines (45 lines for each group) displayed a limited heterogeneous pattern with a biased recognition to peptide 84-102 and the C-terminal peptide 149-171. The reactivity to the 84-102 region of MBP was associated with the HLA-DR2, DRw15 (DRw15,2) haplotype, whereas the recognition to peptide 149-171 did not correlate with a particular HLA-DR allele(s). Furthermore, the majority of T-cell lines (> 75%) were found to exhibit substantial cytotoxic activity against MBP-coated target cells, but showing no significant difference between these two groups. This MBP-dependent cytotoxicity was not associated with epitope specificities of the T-cell lines tested. | - |
dc.language.iso | en | - |
dc.publisher | LITTLE BROWN CO | - |
dc.title | MYELIN BASIC-PROTEIN SPECIFIC LYMPHOCYTE-T IN MULTIPLE-SCLEROSIS AND CONTROLS - PRECURSOR FREQUENCY, FINE SPECIFICITY, AND CYTOTOXICITY | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 338 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 330 | - |
dc.identifier.volume | 32 | - |
local.format.pages | 9 | - |
dc.description.notes | MULTIPLE SCLEROSIS CLIN & REHABIL CTR,OVERPELT,BELGIUM. ST LUKES ROOSEVELT HOSP,NEW YORK,NY 10025. COLUMBIA UNIV,NEW YORK,NY 10027. ACAD HOSP MAASTRICHT,TISSUE TYPING LAB,MAASTRICHT,NETHERLANDS. LIMBURGS UNIV CENTRUM,B-3610 DIEPENBEEK,BELGIUM. DR L WILLEMS INST,MULTIPLE SCLEROSIS RES LAB,DIEPENBEEK,BELGIUM. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.isi | A1992JN14500004 | - |
item.fulltext | No Fulltext | - |
item.fullcitation | HASHIM, GA; YING, C; VANDENBERG-LOONEN, E; MEDAER, Rob; RAUS, Jef & ZHANG, JINGWU (1992) MYELIN BASIC-PROTEIN SPECIFIC LYMPHOCYTE-T IN MULTIPLE-SCLEROSIS AND CONTROLS - PRECURSOR FREQUENCY, FINE SPECIFICITY, AND CYTOTOXICITY. In: ANNALS OF NEUROLOGY, 32(3). p. 330-338. | - |
item.accessRights | Closed Access | - |
item.contributor | HASHIM, GA | - |
item.contributor | YING, C | - |
item.contributor | VANDENBERG-LOONEN, E | - |
item.contributor | MEDAER, Rob | - |
item.contributor | RAUS, Jef | - |
item.contributor | ZHANG, JINGWU | - |
Appears in Collections: | Research publications |
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