ANTIBODIES TO TWO NOVEL PEPTIDES IN NEW ONSET AXIAL SPONDYLOARTHRITIS

Abstract

Scientific Abstracts 799 are not studied. Until now, it remains unclear whether synovitis detected on MRI and ultrasound of hip joint is a predictor of radiological progression of coxitis. Objectives: To determine the factors influencing the progression of coxitis in axSpA. Methods: 77 patients (mean age 28 ± 5.92 years) with a diagnosed with axSpA (ASAS criteria 2009), which were observed for at least 2 years. Among them, AS according to the modified New York criteria (1984)-66 (86%) patients, and 11 (14%) were diagnosed with nr-axSpA. The median duration of the disease was 30 [3-60] months, BASDAI 4.5 [3.2; 5.9], BASFI 2.4 [0.9; 4.8]. All patients underwent clinical, X-ray, ultrasound and MRI examination of the hip joint during the entire observation period. For ultrasound, coxitis was considered an increase in the cervical-capsular distance (CCD) of more than 7 mm. For MRI inflammatory changes were taken as osteitis of the acetabulum and / or femoral head and synovitis in STIR mode. The sum of stages of radiographic coxitis (ssrC) was used to assess HJ injury progression. During the study, a formula was developed to assess the progression rate of radiographic coxitis (R-rpC). Results: Cluster analysis of the main parameters was performed to detect the relationship between the clinical manifestations of axSpA and radiological progression of coxitis (Figure 1). During the analysis, it was found that the most closely related group of clinical parameters, such as the presence of the HLA B 27 gene and the sex of patients, the rate of radiographic progression of cox-itis and srsc (Euclidean distance < 20). The second group of related measures included the BASDAI and ASDAS-CRP disease activity indices, as well as their associated functional impairment (BASFI index) (Euclidean distance < 30). These two groups of signs are also related to each other-Euclidean distance < 30. It should be noted that laboratory indicators of inflammation (ESR and CRP), the age of patients, and especially the duration of the disease, turned out to be weakly related to each other (Euclidean distance > 100). It should also be noted that the relationship between laboratory indicators of inflammation and disease activity indices is relatively weak, as well as with structural damage in axSpA. Figure 1. Conclusion: Factors influencing the development and progression of coxitis in axSpA are a combination of such features as high clinical activity of the disease , the presence of peripheral arthritis, HLA B27 positivity and male sex.