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http://hdl.handle.net/1942/38878
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DC Field | Value | Language |
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dc.contributor.author | VAN HOORNWEDER, Sybren | - |
dc.contributor.author | Caulfield, Kevin A. | - |
dc.contributor.author | Nitsche, Michael | - |
dc.contributor.author | Thielscher, Axel | - |
dc.contributor.author | MEESEN, Raf | - |
dc.date.accessioned | 2022-11-16T10:34:29Z | - |
dc.date.available | 2022-11-16T10:34:29Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-11-14T15:18:17Z | - |
dc.identifier.citation | Journal of Neural Engineering, 19 (5) (Art N° 056045) | - |
dc.identifier.uri | http://hdl.handle.net/1942/38878 | - |
dc.description.abstract | Objective. Transcranial electrical stimulation (tES) is a promising method for modulating brain activity and excitability with variable results to date. To minimize electric (E-)field strength variability, we introduce the 2-sample prospective E-field dosing (2-SPED) approach, which uses E-field strengths induced by tES in a first population to individualize stimulation intensity in a second population. Approach. We performed E-field modeling of three common tES montages in 300 healthy younger adults. First, permutation analyses identified the sample size required to obtain a stable group average E-field in the primary motor cortex (M1), with stability being defined as the number of participants where all group-average E-field strengths +/- standard deviation did not leave the population's 5-95 percentile range. Second, this stable group average was used to individualize tES intensity in a second independent population (n = 100). The impact of individualized versus fixed intensity tES on E-field strength variability was analyzed. Main results. In the first population, stable group average E-field strengths (V/m) in M1 were achieved at 74-85 participants, depending on the tES montage. Individualizing the stimulation intensity (mA) in the second population resulted in uniform M1 E-field strength (all p < 0.001) and significantly diminished peak cortical E-field strength variability (all p < 0.01), across all montages. Significance. 2-SPED is a feasible way to prospectively induce more uniform E-field strengths in a region of interest. Future studies might apply 2-SPED to investigate whether decreased E-field strength variability also results in decreased physiological and behavioral variability in response to tES. | - |
dc.description.sponsorship | This work was supported by the Special Research Fund (BOF) of Hasselt University (BOF20KP18), an NIH NINDS F31 NRSA grant (Principal Investigator: Kevin A Caulfield; 1F31NS126019-01), the Lundbeck foundation (Axel Thielscher; Grant R313-2019-622) and the European Union’s Horizon 2020 research and innovation program (Michael A Nitsche; No. 101017716). Data were provided by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University | - |
dc.language.iso | en | - |
dc.publisher | IOP Publishing Ltd | - |
dc.rights | 2022 The Author(s). Published by IOP Publishing Ltd. Open access | - |
dc.subject.other | electric field (E-field) modeling | - |
dc.subject.other | transcranial electrical stimulation (tES) | - |
dc.subject.other | transcranial direct current stimulation (tDCS) | - |
dc.subject.other | finite element method (FEM) | - |
dc.subject.other | noninvasive brain stimulation | - |
dc.subject.other | computational dosimetry | - |
dc.title | Addressing transcranial electrical stimulation variability through prospective individualized dosing of electric field strength in 300 participants across two samples: the 2-SPED approach | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 5 | - |
dc.identifier.volume | 19 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Van Hoornweder, S (corresponding author), Univ Hasselt, Fac Rehabil Sci, REVAL Rehabil Res Ctr, Diepenbeek, Belgium. | - |
dc.description.notes | Sybren.vanhoornweder@uhasselt.be | - |
local.publisher.place | TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 056045 | - |
dc.identifier.doi | 10.1088/1741-2552/ac9a78 | - |
dc.identifier.pmid | 36240729 | - |
dc.identifier.isi | 000875336600001 | - |
dc.contributor.orcid | Van Hoornweder, Sybren/0000-0002-0325-8950; Caulfield, | - |
dc.contributor.orcid | Kevin/0000-0001-8268-4204 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Van Hoornweder, Sybren; Meesen, Raf L. J.] Univ Hasselt, Fac Rehabil Sci, REVAL Rehabil Res Ctr, Diepenbeek, Belgium. | - |
local.description.affiliation | [Caulfield, Kevin A.] Med Univ South Carolina, Dept Psychiat, Brain Stimulat Lab, Charleston, SC 29425 USA. | - |
local.description.affiliation | [Nitsche, Michael] Leibniz Res Ctr Working Environm & Human Factors, Dept Psychol & Neurosci, Dortmund, Germany. | - |
local.description.affiliation | [Nitsche, Michael] Univ Med Hosp Bergmannsheil, Dept Neurol, Burkle Camp Pl, Bochum, Germany. | - |
local.description.affiliation | [Thielscher, Axel] Tech Univ Denmark, Dept Hlth Technol, Sect Magnet Resonance, Lyngby, Denmark. | - |
local.description.affiliation | [Thielscher, Axel] Copenhagen Univ Hosp Amager & Hvidovre, Danish Res Ctr Magnet Resonance, Ctr Funct & Diagnost Imaging & Res, Copenhagen, Denmark. | - |
local.description.affiliation | [Meesen, Raf L. J.] Katholieke Univ Leuven, Dept Movement Sci, Movement Control & Neuroplast Res Grp, Grp Biomed Sci, Leuven, Belgium. | - |
local.uhasselt.international | yes | - |
item.fullcitation | VAN HOORNWEDER, Sybren; Caulfield, Kevin A.; Nitsche, Michael; Thielscher, Axel & MEESEN, Raf (2022) Addressing transcranial electrical stimulation variability through prospective individualized dosing of electric field strength in 300 participants across two samples: the 2-SPED approach. In: Journal of Neural Engineering, 19 (5) (Art N° 056045). | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2023 | - |
item.contributor | VAN HOORNWEDER, Sybren | - |
item.contributor | Caulfield, Kevin A. | - |
item.contributor | Nitsche, Michael | - |
item.contributor | Thielscher, Axel | - |
item.contributor | MEESEN, Raf | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 1741-2560 | - |
crisitem.journal.eissn | 1741-2552 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Addressing transcranial electrical stimulation variability through prospective individualized dosing of electric field strength in 300 participants across two samples_ the 2-SPED approach.pdf | Published version | 1.99 MB | Adobe PDF | View/Open |
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