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http://hdl.handle.net/1942/38901
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DC Field | Value | Language |
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dc.contributor.author | Chimed, Surenjav | - |
dc.contributor.author | STASSEN, Jan | - |
dc.contributor.author | Galloo, Xavier | - |
dc.contributor.author | Meucci, Maria Chiara | - |
dc.contributor.author | Bijl, Pieter van der | - |
dc.contributor.author | Knuuti, Juhani | - |
dc.contributor.author | Delgado, Victoria | - |
dc.contributor.author | Marsan, Nina Ajmone | - |
dc.contributor.author | Bax, Jeroen J. | - |
dc.date.accessioned | 2022-11-21T11:19:26Z | - |
dc.date.available | 2022-11-21T11:19:26Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-11-18T12:38:18Z | - |
dc.identifier.citation | AMERICAN JOURNAL OF CARDIOLOGY, 184 , p. 63 -71 | - |
dc.identifier.uri | http://hdl.handle.net/1942/38901 | - |
dc.description.abstract | Worsening heart failure (HF), defined as hospitalization for worsening signs and symp-toms of HF or the need for urgent intravenous diuretics, is often considered a surrogate of poor prognosis in clinical trials. However, data on the prognostic implications of worsen-ing HF in patients with HF and reduced ejection fraction is limited. Patients who had a first echocardiographic diagnosis of left ventricular systolic dysfunction, defined as left ventricular ejection fraction (LVEF) <= 45%, were identified. Worsening HF was defined as hospitalization for HF or urgent need for intravenous diuretics. All-cause mortality was chosen as the study end point. A total of 1,801 patients (mean age 64 </n> 12 years, 74% men) were analyzed. Worsening HF was observed in 275 patients (15%) during a median follow-up of 20 months, while, 435 patients (24%) died during a median follow-up of 60 months (Interquartile range 28 to 60 months). The 5-year survival rate was significantly lower in the worsening HF cohort compared with the non-worsening HF cohort (Log-rank p <0.0001), and it was significantly different between the worsening HF cohort and the nonworsening HF cohort for LVEF <= 25% (log-rank p <0.0001) and LVEF 26% to 34% (log-rank p = 0.038) but not for LVEF 35% to 45% (log-rank p = 0.14). After adjustment for important clinical and echocardiographic predictors, worsening HF was independently associated with a higher risk of all-cause mortality (hazard ratio 1.46, 95% confidence interval 1.09 to 1.96, p = 0.011). In conclusion, worsening HF, defined by HF hospitaliza-tion or the urgent need for intravenous diuretics, is independently associated with poor long-term prognosis in patients with HF and reduced ejection fraction. (c) 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) (Am J Cardiol 2022;184:63-71) | - |
dc.description.sponsorship | All individuals who contributed to this publication, have been included as authors. Dr. Chimed reports a relation with European Society of Cardiology that includes funding grants. Dr. Chimed reports a relation with Turku PET Center that includes funding grants. Dr. Delgado reports a relation with Abbott Vascular that includes speaking and lecture fees. Dr. Delgado reports a relation with Edwards Lifesciences that includes speaking and lecture fees. Dr. Delgado reports a relation with GE Healthcare that includes speaking and lecture fees. Dr. Delgado reports a relation with Medtronic that includes speaking and lecture fees. Dr. Delgado reports a relation with Merck Sharp & Dohme that includes speaking and lecture fees. Dr. Delgado reports a relation with Novartis that includes speaking and lecture fees. Dr. Marsan reports a relation with Abbott Vascular that includes speaking and lecture fees. Dr. Marsan reports a relation with GE Healthcare that includes speaking and lecture fees. Dr. Bax reports a relation with Abbott Vascular that includes speaking and lecture fees. The remaining authors have no conflicts of interest to declare. | - |
dc.language.iso | en | - |
dc.publisher | EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC | - |
dc.rights | 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | - |
dc.title | Impact of Worsening Heart Failure on Long-Term Prognosis in Patients With Heart Failure With Reduced Ejection Fraction | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 71 | - |
dc.identifier.spage | 63 | - |
dc.identifier.volume | 184 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Bax, JJ (corresponding author), Leiden Univ, Heart Lung Ctr, Dept Cardiol, Med Ctr, Leiden, Netherlands.; Bax, JJ (corresponding author), Univ Turku, Turku Univ Hosp, Heart Ctr, Turku, Finland. | - |
dc.description.notes | j.j.bax@lumc.nl | - |
local.publisher.place | 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.amjcard.2022.08.035 | - |
dc.identifier.isi | 000877775500009 | - |
dc.contributor.orcid | Chimed, Surenjav/0000-0001-6560-9114; Bax, Jeroen/0000-0001-7368-0500 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Chimed, Surenjav; Stassen, Jan; Galloo, Xavier; Meucci, Maria Chiara; Bijl, Pieter van der; Knuuti, Juhani; Delgado, Victoria; Marsan, Nina Ajmone; Bax, Jeroen J.] Leiden Univ, Heart Lung Ctr, Dept Cardiol, Med Ctr, Leiden, Netherlands. | - |
local.description.affiliation | [Stassen, Jan] Jessa Hosp, Dept Cardiol, Hasselt, Belgium. | - |
local.description.affiliation | [Bax, Jeroen J.] Univ Turku, Turku Univ Hosp, Heart Ctr, Turku, Finland. | - |
local.uhasselt.international | yes | - |
item.contributor | Chimed, Surenjav | - |
item.contributor | STASSEN, Jan | - |
item.contributor | Galloo, Xavier | - |
item.contributor | Meucci, Maria Chiara | - |
item.contributor | Bijl, Pieter van der | - |
item.contributor | Knuuti, Juhani | - |
item.contributor | Delgado, Victoria | - |
item.contributor | Marsan, Nina Ajmone | - |
item.contributor | Bax, Jeroen J. | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | Chimed, Surenjav; STASSEN, Jan; Galloo, Xavier; Meucci, Maria Chiara; Bijl, Pieter van der; Knuuti, Juhani; Delgado, Victoria; Marsan, Nina Ajmone & Bax, Jeroen J. (2022) Impact of Worsening Heart Failure on Long-Term Prognosis in Patients With Heart Failure With Reduced Ejection Fraction. In: AMERICAN JOURNAL OF CARDIOLOGY, 184 , p. 63 -71. | - |
crisitem.journal.issn | 0002-9149 | - |
crisitem.journal.eissn | 1879-1913 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Impact of Worsening Heart Failure on Long-Term Prognosis in Patients With Heart Failure With Reduced Ejection Fraction.pdf | Published version | 1.14 MB | Adobe PDF | View/Open |
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