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http://hdl.handle.net/1942/38903
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DC Field | Value | Language |
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dc.contributor.author | Garot, Philippe | - |
dc.contributor.author | Neylon, Antoinette | - |
dc.contributor.author | Morice, Marie -Claude | - |
dc.contributor.author | Tamburino, Corrado | - |
dc.contributor.author | Bleiziffer, Sabine | - |
dc.contributor.author | Thiele, Holger | - |
dc.contributor.author | Scholtz, Smita | - |
dc.contributor.author | Schramm, Rene | - |
dc.contributor.author | Cockburn, James | - |
dc.contributor.author | Cunnington, Michael | - |
dc.contributor.author | Wolf, Alexander | - |
dc.contributor.author | Barbanti, Marco | - |
dc.contributor.author | Tchetche, Didier | - |
dc.contributor.author | Pagnotta, Paolo | - |
dc.contributor.author | Gilard, Martine | - |
dc.contributor.author | Bedogni, Francesco | - |
dc.contributor.author | Van Belle, Eric | - |
dc.contributor.author | Vasa-Nicotera, Mauca | - |
dc.contributor.author | Chieffo, Alaide | - |
dc.contributor.author | BOGAERTS, Kris | - |
dc.contributor.author | Hengstenberg, Christian | - |
dc.contributor.author | Capodanno, Davide | - |
dc.date.accessioned | 2022-11-21T12:19:03Z | - |
dc.date.available | 2022-11-21T12:19:03Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-11-18T12:02:14Z | - |
dc.identifier.citation | EuroIntervention, 18 (6) , p. 503 -+ | - |
dc.identifier.issn | 1774-024X | - |
dc.identifier.uri | http://hdl.handle.net/1942/38903 | - |
dc.description.abstract | Background: The Academic Research Consortium - High Bleeding Risk (ARC-HBR) initiative defined conditions associated with percutaneous coronary intervention (PCI)-related bleeding.Aims: We sought to further explore these HBR conditions in the setting of transcatheter aortic valve replacement (TAVR).Methods: Patients from the SCOPE 2 trial were stratified by their bleeding risk status based on the ARC-HBR definitions. Baseline and procedural characteristics, as well as key clinical outcomes including Bleeding Academic Research Consortium (BARC) 3-5 bleeding, were compared in ARC-HBR positive (HBR+) and ARC-HBR negative (HBR-) patients.Results: Of 787 patients randomised in SCOPE 2 and included in this study, 633 were HBR+ (80.4%). Compared with HBR- patients, those HBR+ were older and more frequently presented with diabetes, a his-tory of coronary artery disease, atrial fibrillation, prior cerebrovascular accident, and a Society of Thoracic Surgeons predicted risk of 30-day mortality (STS-PROM) (4.9 +/- 2.9% vs 3.3%+/- 2.1%; p<0.0001). In addition, HBR+ patients were more frequently on oral anticoagulation therapy. At 1 year, HBR+ patients had higher rates of all-cause death (12.4% vs 4.3%, respectively, risk difference 8.09%; 95% confidence interval [CI]: 3.76-12.41; p=0.0002); the rates of BARC 3-5 type bleeding were relatively high but not statistically different compared with HBR- patients (7.7% vs 6.1%, risk difference 1.67%; 95% CI: -2.72 to 6.06; p=0.46). Subgroup analyses for bleeding events showed no significant interaction in terms of STS-PROM score, age, or medications.Conclusions: The ARC-HBR criteria failed to isolate a subgroup of patients at higher bleeding risk in TAVR patients from a randomised trial. These findings have potential implications, especially for the selection of post-TAVR antithrombotic regimens based on individual bleeding-risk profiles. Specific HBR criteria should be defined for TAVR patients. | - |
dc.description.sponsorship | The SCOPE 2 Trial is an investigator-initiated trial, funded by CERIC. The authors are grateful to Mrs. Dupic for her skillful assistance in reviewing the present manuscript. | - |
dc.language.iso | en | - |
dc.publisher | EUROPA EDITION | - |
dc.rights | Europa Digital & Publishing 2022. All rights reserved | - |
dc.subject.other | bleeding | - |
dc.subject.other | TAVR | - |
dc.title | Bleeding risk differences after TAVR according to the ARC-HBR criteria: insights from SCOPE 2 | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | + | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 503 | - |
dc.identifier.volume | 18 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Garot, P (corresponding author), Hop Jacques Cartier, Inst Cardiovasc Paris Sud, 6 Ave Noyer Lambert, F-91300 Massy, France. | - |
dc.description.notes | pgarot@angio-icps.com | - |
local.publisher.place | 19 ALLEES JEAN JAURES B P 61508, TOULOUSE CEDEX 6, 31015, FRANCE | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.4244/EIJ-D-21-01048 | - |
dc.identifier.pmid | 35450838 | - |
dc.identifier.isi | 000877728200011 | - |
dc.identifier.eissn | 1969-6213 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Garot, Philippe; Neylon, Antoinette; Morice, Marie -Claude] Hop Pr Jacques Cartier, Inst Cardiovasc Paris Sud, Ramsay St, Massy, France. | - |
local.description.affiliation | [Tamburino, Corrado; Capodanno, Davide] Vittorio Emanuele Univ Catania, Div Cardiol Azienda Ospedaliero Universitaria Poli, Catania, Italy. | - |
local.description.affiliation | [Bleiziffer, Sabine; Schramm, Rene] Univ Hosp, Ruhr Univ Bochum, Heart & Diabet Ctr Northrhein Westfalia, Dept Thorac & Cardiovasc Surg, Bad Oeynhausen, Germany. | - |
local.description.affiliation | [Thiele, Holger] Univ Leipzig, Leipzig Heart Ctr, Dept Cardiol, Leipzig, Germany. | - |
local.description.affiliation | [Scholtz, Smita] Heart & Diabet Ctr North Rhine Westfalia, Dept Intervent Cardiol, Bad Oeynhausen, Germany. | - |
local.description.affiliation | [Cockburn, James] Brighton & Sussex Univ Hosp NHS Trust, Dept Cardiol, Brighton, East Sussex, England. | - |
local.description.affiliation | [Cunnington, Michael] Leeds Teaching Hosp NHS Trust, Leeds Gen Infirm, Dept Cardiol, Leeds, England. | - |
local.description.affiliation | [Wolf, Alexander] Elisabeth Hosp Essen, Dept Intervent Cardiol, Essen, Germany. | - |
local.description.affiliation | [Barbanti, Marco] Dept Cardiothorac Vasc Dis & transplantat, Azienda Ospedaliero Universitaria Policlin G Rodol, Catania, Italy. | - |
local.description.affiliation | [Tchetche, Didier] Grp Cardiovasc Intervent, Clin Pasteur, Toulouse, France. | - |
local.description.affiliation | [Pagnotta, Paolo] Human Clin & Res Ctr, Dept Cardiovasc Med, Milan, Italy. | - |
local.description.affiliation | [Gilard, Martine] Brest Univ Hosp, Dept Cardiol, Brest, France. | - |
local.description.affiliation | [Bedogni, Francesco] Cardiol Dept, IRCCS Policlin San Donato, Milan, Italy. | - |
local.description.affiliation | [Van Belle, Eric] Lille Univ Hosp, Dept Cardiol, Lille, France. | - |
local.description.affiliation | Goethe Univ Hosp Frankfurt, Dept Cardiol, Frankfurt, Germany. | - |
local.description.affiliation | [Chieffo, Alaide] IRCCS San Raffaele Sci Inst, Intervent Cardiol Unit, Milan, Italy. | - |
local.description.affiliation | [Morice, Marie -Claude] Katholieke Univ Leuven, Fac Med, I BioStat, Hasselt, Belgium. | - |
local.description.affiliation | [Hengstenberg, Christian] Med Univ Vienna, Dept Internal Med 2, Vienna, Austria. | - |
local.description.affiliation | [Garot, Philippe] Hop Jacques Cartier, Inst Cardiovasc Paris Sud, 6 Ave Noyer Lambert, F-91300 Massy, France. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.fullcitation | Garot, Philippe; Neylon, Antoinette; Morice, Marie -Claude; Tamburino, Corrado; Bleiziffer, Sabine; Thiele, Holger; Scholtz, Smita; Schramm, Rene; Cockburn, James; Cunnington, Michael; Wolf, Alexander; Barbanti, Marco; Tchetche, Didier; Pagnotta, Paolo; Gilard, Martine; Bedogni, Francesco; Van Belle, Eric; Vasa-Nicotera, Mauca; Chieffo, Alaide; BOGAERTS, Kris; Hengstenberg, Christian & Capodanno, Davide (2022) Bleeding risk differences after TAVR according to the ARC-HBR criteria: insights from SCOPE 2. In: EuroIntervention, 18 (6) , p. 503 -+. | - |
item.accessRights | Restricted Access | - |
item.contributor | Garot, Philippe | - |
item.contributor | Neylon, Antoinette | - |
item.contributor | Morice, Marie -Claude | - |
item.contributor | Tamburino, Corrado | - |
item.contributor | Bleiziffer, Sabine | - |
item.contributor | Thiele, Holger | - |
item.contributor | Scholtz, Smita | - |
item.contributor | Schramm, Rene | - |
item.contributor | Cockburn, James | - |
item.contributor | Cunnington, Michael | - |
item.contributor | Wolf, Alexander | - |
item.contributor | Barbanti, Marco | - |
item.contributor | Tchetche, Didier | - |
item.contributor | Pagnotta, Paolo | - |
item.contributor | Gilard, Martine | - |
item.contributor | Bedogni, Francesco | - |
item.contributor | Van Belle, Eric | - |
item.contributor | Vasa-Nicotera, Mauca | - |
item.contributor | Chieffo, Alaide | - |
item.contributor | BOGAERTS, Kris | - |
item.contributor | Hengstenberg, Christian | - |
item.contributor | Capodanno, Davide | - |
crisitem.journal.issn | 1774-024X | - |
crisitem.journal.eissn | 1969-6213 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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bleeding-risk-differences-after-tavr-according-to-the-arc-hbr-criteria-insights-.pdf Restricted Access | Published version | 628.96 kB | Adobe PDF | View/Open Request a copy |
BleedingRiskDifference-Submitted version.pdf Restricted Access | Peer-reviewed author version | 479.08 kB | Adobe PDF | View/Open Request a copy |
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