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http://hdl.handle.net/1942/38908
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DC Field | Value | Language |
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dc.contributor.author | Smits, Pieter C. | - |
dc.contributor.author | Frigoli, Enrico | - |
dc.contributor.author | VRANCKX, Pascal | - |
dc.contributor.author | Ozaki, Yukio | - |
dc.contributor.author | Morice, Marie -Claude | - |
dc.contributor.author | Chevalier, Bernard | - |
dc.contributor.author | Onuma, Yoshinobu | - |
dc.contributor.author | Windecker, Stephan | - |
dc.contributor.author | Tonino, Pim A. L. | - |
dc.contributor.author | Roffi, Marco | - |
dc.contributor.author | Lesiak, Maciej | - |
dc.contributor.author | Mahfoud, Felix | - |
dc.contributor.author | Bartunek, Jozef | - |
dc.contributor.author | Hildick-Smith, David | - |
dc.contributor.author | Colombo, Antonio | - |
dc.contributor.author | Stankovic, Goran | - |
dc.contributor.author | Iniguez, Andres | - |
dc.contributor.author | Schultz, Carl | - |
dc.contributor.author | Kornowski, Ran | - |
dc.contributor.author | Ong, Paul J. L. | - |
dc.contributor.author | Alasnag, Mirvat | - |
dc.contributor.author | Rodriguez, Alfredo E. | - |
dc.contributor.author | Paradies, Valeria | - |
dc.contributor.author | Kala, Petr | - |
dc.contributor.author | Kedev, Sasko | - |
dc.contributor.author | Al Mafragi, Amar | - |
dc.contributor.author | Dewilde, Willem | - |
dc.contributor.author | Heg, Dik | - |
dc.contributor.author | Valgimigli, Marco | - |
dc.contributor.author | MASTER DAPT Investigators | - |
dc.date.accessioned | 2022-11-23T08:08:38Z | - |
dc.date.available | 2022-11-23T08:08:38Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-11-18T12:35:11Z | - |
dc.identifier.citation | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 80 (13) , p. 1220 -1237 | - |
dc.identifier.uri | http://hdl.handle.net/1942/38908 | - |
dc.description.abstract | BACKGROUND The optimal duration of antiplatelet therapy (APT) after coronary stenting in patients at high bleeding risk (HBR) presenting with an acute coronary syndrome remains unclear.OBJECTIVES The objective of this study was to investigate the safety and efficacy of an abbreviated APT regimen after coronary stenting in an HBR population presenting with acute or recent myocardial infarction.METHODS In the MASTER DAPT trial, 4,579 patients at HBR were randomized after 1 month of dual APT (DAPT) to abbreviated (DAPT stopped and 11 months single APT or 5 months in patients with oral anticoagulants) or nonabbreviated APT (DAPT for minimum 3 months) strategies. Randomization was stratified by acute or recent myocardial infarction at index procedure. Coprimary outcomes at 335 days after randomization were net adverse clinical outcomes events (NACE); major adverse cardiac and cerebral events (MACCE); and type 2, 3, or 5 Bleeding Academic Research Consortium bleeding.RESULTS NACE and MACCE did not differ with abbreviated vs nonabbreviated APT regimens in patients with an acute or recent myocardial infarction (n =1,780; HR: 0.83; 95% CI: 0.61-1.12 and HR: 0.86; 95% CI: 0.62-1.19, respectively) or without an acute or recent myocardial infarction (n = 2,799; HR: 1.03; 95% CI: 0.77-1.38 and HR: 1.13; 95% CI: 0.80-1.59; Pinteraction = 0.31 and 0.25, respectively). Bleeding Academic Research Consortium 2, 3, or 5 bleeding was signifi-cantly reduced in patients with or without an acute or recent myocardial infarction (HR: 0.65; 95% CI: 0.46-0.91 and HR: 0.71; 95% CI: 0.54-0.92; Pinteraction = 0.72) with abbreviated APT.CONCLUSIONS A 1-month DAPT strategy in patients with HBR presenting with an acute or recent myocardial infarction results in similar NACE and MACCE rates and reduces bleedings compared with a nonabbreviated DAPT strategy. (Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Prolonged DAPT Regimen [MASTER DAPT]; NCT03023020) (J Am Coll Cardiol 2022;80:1220-1237) (c) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.rights | 2022 THE AUTHORS. PUBLISHED BY ELSEVIER ON BEHALF OF THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION. THIS IS AN OPEN ACCESS ARTICLE UNDER THE CC BY-NC-ND LICENSE ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ) . | - |
dc.subject.other | acute coronary syndrome | - |
dc.subject.other | antiplatelet therapy | - |
dc.subject.other | dual antiplatelet therapy | - |
dc.subject.other | percutaneous coronary intervention | - |
dc.title | Abbreviated Antiplatelet Therapy After Coronary Stenting in Patients With Myocardial Infarction at High Bleeding Risk | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1237 | - |
dc.identifier.issue | 13 | - |
dc.identifier.spage | 1220 | - |
dc.identifier.volume | 80 | - |
local.format.pages | 18 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Smits, PC (corresponding author), Maasstad Zie kenhuis, Dept Cardiol, Maasstadweg 21, NL-3079 DZ Rotterdam, Netherlands. | - |
dc.description.notes | SmitsP@maasstadziekenhuis.nl | - |
local.publisher.place | STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.jacc.2022.07.016 | - |
dc.identifier.pmid | 36137672 | - |
dc.identifier.isi | 000875244600004 | - |
dc.contributor.orcid | Schultz, Carl/0000-0002-0847-4361 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Smits, Pieter C.; Paradies, Valeria] Maasstad Hosp, Dept Cardiol, Rotterdam, Netherlands. | - |
local.description.affiliation | [Frigoli, Enrico; Heg, Dik] Univ Bern, Clin Trial Unit, Bern, Switzerland. | - |
local.description.affiliation | [Vranckx, Pascal] Jessa Ziekenhuis, Dept Cardiol & Crit Care Med, Hartcentrum Hasselt, Hasselt, Belgium. | - |
local.description.affiliation | [Vranckx, Pascal] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. | - |
local.description.affiliation | [Ozaki, Yukio] Fujita Hlth Univ, Dept Cardiol, Sch Med, Toyoake, Aichi, Japan. | - |
local.description.affiliation | [Morice, Marie -Claude] Cardiovasc European Res Ctr CERC, Massy, France. | - |
local.description.affiliation | [Chevalier, Bernard] Inst Cardiovasc Paris Sud, Intervent Cardiol Dept, Ramsay Gen Sante, Massy, France. | - |
local.description.affiliation | [Onuma, Yoshinobu] Natl Univ Ireland, Galway, Ireland. | - |
local.description.affiliation | [Windecker, Stephan] Bern Univ Hosp, Dept Cardiol, Bern, Switzerland. | - |
local.description.affiliation | [Tonino, Pim A. L.] Catharina Hosp, Dept Cardiol, Eindhoven, Netherlands. | - |
local.description.affiliation | [Roffi, Marco] Geneva Univ Hosp, Div Cardiol, Geneva, Switzerland. | - |
local.description.affiliation | [Lesiak, Maciej] Univ Med Sci, Dept Cardiol 1, Poznan, Poland. | - |
local.description.affiliation | [Mahfoud, Felix] Saarland Univ, Dept Cardiol, Angiol, Intens Care Med, Homburg, Germany. | - |
local.description.affiliation | [Bartunek, Jozef] Onze Lieve Vrouw Hosp, Cardiovasc Ctr, Aalst, Belgium. | - |
local.description.affiliation | [Hildick-Smith, David] Brighton & Sussex Univ Hosp NHS Trust, Brighton, England. | - |
local.description.affiliation | [Colombo, Antonio] Humanitas Univ, Pieve Emanuele Milan & Human Clin & Res Ctr IRCCS, Dept Biomed Sci, Milan, Italy. | - |
local.description.affiliation | [Stankovic, Goran] Univ Belgrade, Fac Med, Clin Ctr Serbia, Dept Cardiol, Belgrade, Serbia. | - |
local.description.affiliation | [Iniguez, Andres] Hosp Alvaro Cunqueiro, Vigo, Spain. | - |
local.description.affiliation | [Schultz, Carl] Univ Western Australia, Royal Perth Hosp Campus, Dept Cardiol, Perth, WA, Australia. | - |
local.description.affiliation | [Kornowski, Ran] Tel Aviv Univ, Rabin Med Ctr, Sackler Sch Med, Tel Aviv, Israel. | - |
local.description.affiliation | [Ong, Paul J. L.] Tan Tock Seng Hosp, Singapore, Singapore. | - |
local.description.affiliation | [Alasnag, Mirvat] King Fahad Armed Forces Hosp, Cardiac Ctr, Jeddah, Saudi Arabia. | - |
local.description.affiliation | [Rodriguez, Alfredo E.] Otamendi Hosp, Cardiovasc Res Ctr CECI, Cardiac Unit, Buenos Aires Sch Med, Buenos Aires, Argentina. | - |
local.description.affiliation | [Kala, Petr] Univ Hosp Brno, Brno, Czech Republic. | - |
local.description.affiliation | [Kedev, Sasko] Ss Cyril & Methodius Univ, Univ Clin Cardiol, Skopje, North Macedonia. | - |
local.description.affiliation | [Al Mafragi, Amar] Zorgsaam Hosp, Dept Cardiol, Terneuzen, Netherlands. | - |
local.description.affiliation | [Dewilde, Willem] Imelda Hosp Bonheiden, Dept Cardiol, Bonheiden, Belgium. | - |
local.description.affiliation | [Valgimigli, Marco] Univ Svizzera Italiana USI, Cardioctr Ticino Inst, Ente Osped Cantonale, CH-6900 Lugano, Switzerland. | - |
local.description.affiliation | [Smits, Pieter C.] Maasstad Zie kenhuis, Dept Cardiol, Maasstadweg 21, NL-3079 DZ Rotterdam, Netherlands. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2023 | - |
item.contributor | Smits, Pieter C. | - |
item.contributor | Frigoli, Enrico | - |
item.contributor | VRANCKX, Pascal | - |
item.contributor | Ozaki, Yukio | - |
item.contributor | Morice, Marie -Claude | - |
item.contributor | Chevalier, Bernard | - |
item.contributor | Onuma, Yoshinobu | - |
item.contributor | Windecker, Stephan | - |
item.contributor | Tonino, Pim A. L. | - |
item.contributor | Roffi, Marco | - |
item.contributor | Lesiak, Maciej | - |
item.contributor | Mahfoud, Felix | - |
item.contributor | Bartunek, Jozef | - |
item.contributor | Hildick-Smith, David | - |
item.contributor | Colombo, Antonio | - |
item.contributor | Stankovic, Goran | - |
item.contributor | Iniguez, Andres | - |
item.contributor | Schultz, Carl | - |
item.contributor | Kornowski, Ran | - |
item.contributor | Ong, Paul J. L. | - |
item.contributor | Alasnag, Mirvat | - |
item.contributor | Rodriguez, Alfredo E. | - |
item.contributor | Paradies, Valeria | - |
item.contributor | Kala, Petr | - |
item.contributor | Kedev, Sasko | - |
item.contributor | Al Mafragi, Amar | - |
item.contributor | Dewilde, Willem | - |
item.contributor | Heg, Dik | - |
item.contributor | Valgimigli, Marco | - |
item.contributor | MASTER DAPT Investigators | - |
item.accessRights | Open Access | - |
item.fullcitation | Smits, Pieter C.; Frigoli, Enrico; VRANCKX, Pascal; Ozaki, Yukio; Morice, Marie -Claude; Chevalier, Bernard; Onuma, Yoshinobu; Windecker, Stephan; Tonino, Pim A. L.; Roffi, Marco; Lesiak, Maciej; Mahfoud, Felix; Bartunek, Jozef; Hildick-Smith, David; Colombo, Antonio; Stankovic, Goran; Iniguez, Andres; Schultz, Carl; Kornowski, Ran; Ong, Paul J. L.; Alasnag, Mirvat; Rodriguez, Alfredo E.; Paradies, Valeria; Kala, Petr; Kedev, Sasko; Al Mafragi, Amar; Dewilde, Willem; Heg, Dik; Valgimigli, Marco & MASTER DAPT Investigators (2022) Abbreviated Antiplatelet Therapy After Coronary Stenting in Patients With Myocardial Infarction at High Bleeding Risk. In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 80 (13) , p. 1220 -1237. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0735-1097 | - |
crisitem.journal.eissn | 1558-3597 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Abbreviated Antiplatelet Therapy After Coronary Stenting in Patients With Myocardial Infarction at High Bleeding Risk.pdf | Published version | 2.33 MB | Adobe PDF | View/Open |
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