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http://hdl.handle.net/1942/38974
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DC Field | Value | Language |
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dc.contributor.author | RASKING, Leen | - |
dc.contributor.author | Roelens, Céline | - |
dc.contributor.author | SPRANGERS, Ben | - |
dc.contributor.author | Thienpont, Bernard | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | De Vusser, Katrien | - |
dc.date.accessioned | 2022-12-02T15:00:16Z | - |
dc.date.available | 2022-12-02T15:00:16Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-11-21T12:55:55Z | - |
dc.identifier.citation | International journal of environmental research and public health (Print), 19 (22) (Art N° 15050) | - |
dc.identifier.issn | 1660-4601 | - |
dc.identifier.uri | http://hdl.handle.net/1942/38974 | - |
dc.description.abstract | The pathogenesis of systemic lupus erythematosus (SLE) remains elusive to this day; however, genetic, epigenetic, and environmental factors have been implicated to be involved in disease pathogenesis. Recently, it was demonstrated that in systemic lupus erythematosus (SLE) patients, interferon-regulated genes are hypomethylated in naïve CD4 + T cells, CD19 + B lymphocytes, and CD14 + monocytes. This suggests that interferon-regulated genes may have been epigenetically poised in SLE patients for rapid expression upon stimulation by different environmental factors. Additionally, environmental studies have identified DNA (hypo)methylation changes as a potential mechanism of environmentally induced health effects in utero, during childhood and in adults. Finally, epidemiologic studies have firmly established air pollution as a crucial SLE risk factor, as studies showed an association between fine particulate matter (PM 2.5) and traditional SLE biomarkers related to disease flare, hospital admissions, and an increased SLEDAI score. In this review, the relationship between aberrant epigenetic regulation, the environment, and the development of SLE will be discussed. | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | - |
dc.subject.other | systemic lupus erythematosus | - |
dc.subject.other | lupus | - |
dc.subject.other | DNA methylation | - |
dc.subject.other | interferon | - |
dc.subject.other | air pollution | - |
dc.subject.other | particulate matter | - |
dc.subject.other | black carbon | - |
dc.title | Lupus, DNA Methylation, and Air Pollution: A Malicious Triad | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 22 | - |
dc.identifier.volume | 19 | - |
local.bibliographicCitation.jcat | A2 | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
local.bibliographicCitation.artnr | 15050 | - |
dc.identifier.doi | 10.3390/ijerph192215050 | - |
dc.identifier.isi | 000887292500001 | - |
local.provider.type | - | |
local.uhasselt.international | no | - |
item.contributor | RASKING, Leen | - |
item.contributor | Roelens, Céline | - |
item.contributor | SPRANGERS, Ben | - |
item.contributor | Thienpont, Bernard | - |
item.contributor | NAWROT, Tim | - |
item.contributor | De Vusser, Katrien | - |
item.validation | ecoom 2023 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | RASKING, Leen; Roelens, Céline; SPRANGERS, Ben; Thienpont, Bernard; NAWROT, Tim & De Vusser, Katrien (2022) Lupus, DNA Methylation, and Air Pollution: A Malicious Triad. In: International journal of environmental research and public health (Print), 19 (22) (Art N° 15050). | - |
crisitem.journal.issn | 1661-7827 | - |
crisitem.journal.eissn | 1660-4601 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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ijerph-19-15050-v2 (1).pdf | Published version | 946.91 kB | Adobe PDF | View/Open |
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