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http://hdl.handle.net/1942/39005
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DC Field | Value | Language |
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dc.contributor.author | Ono, Masafumi | - |
dc.contributor.author | Hara, Hironori | - |
dc.contributor.author | Kawashima, Hideyuki | - |
dc.contributor.author | Gao, Chao | - |
dc.contributor.author | Wang , Rutao | - |
dc.contributor.author | Wykrzykowska, Joanna J. | - |
dc.contributor.author | Piek, Jan J. | - |
dc.contributor.author | Garg, Scot | - |
dc.contributor.author | Hamm, Christian | - |
dc.contributor.author | Steg, Philippe Gabriel | - |
dc.contributor.author | Valgimigli, Marco | - |
dc.contributor.author | Windecker, Stephan | - |
dc.contributor.author | VRANCKX, Pascal | - |
dc.contributor.author | Onuma, Yoshinobu | - |
dc.contributor.author | Serruys, Patrick W. | - |
dc.date.accessioned | 2022-12-06T08:54:54Z | - |
dc.date.available | 2022-12-06T08:54:54Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-12-01T12:07:46Z | - |
dc.identifier.citation | EuroIntervention, 18 (5) , p. E377 -+ | - |
dc.identifier.uri | http://hdl.handle.net/1942/39005 | - |
dc.description.abstract | Background: The optimal antiplatelet strategy in the second year after percutaneous coronary intervention (PCI) remains unclear. Aims: We aimed to compare ticagrelor monotherapy with aspirin monotherapy on clinical outcomes be and 1 year post-PCI. Methods: This post hoc subanalysis of the open-label, all-corners, randomised GLOBAL LEADERS trial, which con pared 23-month ticagrelor monotherapy following 1-month dual antiplatelet therapy (DAPT) with 12-month aspirin monotherapy following 12-month DAPT, only included patients who, at 12 months, were free from ischaemic and bleeding events and were adherent to their assigned antiplatelet therapy. The incidences of ischaemic events (all-cause death, any myocardial infarction, or any stroke) and bleeding events (Bleeding Academic Research Consortium [BARC] type 3 or 5 bleeding) during the second year (12-24 months) were compared between patients receiving either ticagrelor or aspirin monotherapy. Results: The present analysis included 11,121 (ticagrelor monotherapy n=5,308, and aspirin monotherapy n=5,813) of the 15,991 patients enrolled in GLOBAL LEADERS. During the second year, the ischaemic composite endpoint was lower with ticagrelor monotherapy compared to aspirin monotherapy (1.9% vs 2.6%: log-rank p=0.014, adjusted hazard ratio [BR] 0.74, 95% confidence interval [CI]: 0.58-0.96; p=0.022), which was primarily driven by a reduced risk of myocardial infarction. In contrast, BARC type 3 or 5 bleeding was numerically higher with ticagrelor monotherapy (0.5% vs 0.3%: log-rank - 0.051, adjusted HR 1.89, 95% CI: 1.03-3.45; p=0.005). Conclusions: Patients free from events at the end of the first year post-PCI and who adhered to their prescribed regimen had a reduced risk of ischaemic events compared to aspirin monotherapy in the second year post-PCI. | - |
dc.description.sponsorship | GLOBAL LEADERS was sponsored by the European Clinical Research Institute, which received funding from AstraZeneca, Biosensors International, and the Medicines Company. | - |
dc.language.iso | en | - |
dc.publisher | EUROPA EDITION | - |
dc.rights | Europa Digital & Publishing 2022. All rights reserved. | - |
dc.subject.other | ACS/NSTE-ACS | - |
dc.subject.other | adjunctive pharmacotherapy | - |
dc.subject.other | drug-eluting stentst | - |
dc.subject.other | able angina | - |
dc.title | Ticagrelor monotherapy versus aspirin monotherapy at 12 months after percutaneous coronary intervention: a landmark analysis of the GLOBAL LEADERS trial | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | + | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | E377 | - |
dc.identifier.volume | 18 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Serruys, PW (corresponding author), Natl Univ Ireland, Dept Cardiol, Univ Rd, Galway H91 TK33, Ireland. | - |
dc.description.notes | pairick.serruys@nuigalway.ie | - |
local.publisher.place | 19 ALLEES JEAN JAURES B P 61508, TOULOUSE CEDEX 6, 31015, FRANCE | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.4244/EIJ-D-21-00870 | - |
dc.identifier.pmid | 35260381 | - |
dc.identifier.isi | 000882974700005 | - |
dc.contributor.orcid | Wang, Rutao/0000-0002-1473-9709 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Ono, Masafumi; Hara, Hironori; Kawashima, Hideyuki; Wykrzykowska, Joanna J.; Piek, Jan J.] Univ Amsterdam, Heart Ctr, Dept Clin & Expt Cardiol, Amsterdam Cardiovasc Sci,Amsterdam UMC, Amsterdam, Netherlands. | - |
local.description.affiliation | [Ono, Masafumi; Hara, Hironori; Kawashima, Hideyuki; Gao, Chao; Wang, Rutao; Onuma, Yoshinobu; Serruys, Patrick W.] Natl Univ Ireland, Dept Cardiol, Galway NUIG, Galway, Ireland. | - |
local.description.affiliation | [Gao, Chao; Wang, Rutao] Radboud Univ Nijmegen, Dept Cardiol, Med Ctr, Nijmegen, Netherlands. | - |
local.description.affiliation | [Wykrzykowska, Joanna J.] Univ Med Ctr Groningen, Groningen, Netherlands. | - |
local.description.affiliation | [Garg, Scot] Royal Blackburn Hosp, Dept Cardiol, Blackburn, Lancs, England. | - |
local.description.affiliation | [Hamm, Christian] Univ Giessen, Bad Nauheim, Germany. | - |
local.description.affiliation | [Hamm, Christian] Univ Giessen, Kerckhoff Heartand Thorax Centel, Bad Nauheim, Germany. | - |
local.description.affiliation | [Steg, Philippe Gabriel] Univ Paris, AP HP, FACT French Alliance Cardiovasc Trials, Paris, France. | - |
local.description.affiliation | [Valgimigli, Marco] Cardioctr Ticino Inst, Lugano, Switzerland. | - |
local.description.affiliation | [Valgimigli, Marco] Univ Svizzera Italiana USI, Lugano, Switzerland. | - |
local.description.affiliation | [Windecker, Stephan] Univ Bern, Dept Cardiol, Inselspital, Bern, Switzerland. | - |
local.description.affiliation | [Vranckx, Pascal] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. | - |
local.description.affiliation | [Serruys, Patrick W.] Imperial Coll London, NHLI, London, England. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Ono, Masafumi; Hara, Hironori; Kawashima, Hideyuki; Gao, Chao; Wang , Rutao; Wykrzykowska, Joanna J.; Piek, Jan J.; Garg, Scot; Hamm, Christian; Steg, Philippe Gabriel; Valgimigli, Marco; Windecker, Stephan; VRANCKX, Pascal; Onuma, Yoshinobu & Serruys, Patrick W. (2022) Ticagrelor monotherapy versus aspirin monotherapy at 12 months after percutaneous coronary intervention: a landmark analysis of the GLOBAL LEADERS trial. In: EuroIntervention, 18 (5) , p. E377 -+. | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
item.contributor | Ono, Masafumi | - |
item.contributor | Hara, Hironori | - |
item.contributor | Kawashima, Hideyuki | - |
item.contributor | Gao, Chao | - |
item.contributor | Wang , Rutao | - |
item.contributor | Wykrzykowska, Joanna J. | - |
item.contributor | Piek, Jan J. | - |
item.contributor | Garg, Scot | - |
item.contributor | Hamm, Christian | - |
item.contributor | Steg, Philippe Gabriel | - |
item.contributor | Valgimigli, Marco | - |
item.contributor | Windecker, Stephan | - |
item.contributor | VRANCKX, Pascal | - |
item.contributor | Onuma, Yoshinobu | - |
item.contributor | Serruys, Patrick W. | - |
item.validation | ecoom 2023 | - |
crisitem.journal.issn | 1774-024X | - |
crisitem.journal.eissn | 1969-6213 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Ticagrelor monotherapy.pdf Restricted Access | Peer-reviewed author version | 1.63 MB | Adobe PDF | View/Open Request a copy |
ticagrelor_monotherapy_versus_aspirin_monotherapy_at_12_months_after_percutaneou.pdf Restricted Access | Published version | 690.98 kB | Adobe PDF | View/Open Request a copy |
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