ROLE OF NA+/K+ EXCHANGE AND ORGANIC-ACIDS IN BASE INDUCED HYPERPOLARIZATION OF RENAL PROXIMAL AMPHIBIAN TUBULE

Abstract

Fast peritubular alkaline perturbations in Necturus renal proximal tubule evoke hyperpolarizations of the basolateral membrane. These voltage changes are partly due to an increase in basolateral K+-permeability. Additional role of the Na+/K+-ATPase and organic acids in generating these base induced hyperpolarizations (BIH) can be deduced from the reduction in BIH during low K+, high amiloride or omission of organic acids.