Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/39061
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dc.contributor.authorDe Hert, Emilie-
dc.contributor.authorVERBOVEN, Kenneth-
dc.contributor.authorWOUTERS, Kristiaan-
dc.contributor.authorJocken, Johan W. E.-
dc.contributor.authorDe Meester, Ingrid-
dc.date.accessioned2022-12-15T15:24:58Z-
dc.date.available2022-12-15T15:24:58Z-
dc.date.issued2022-
dc.date.submitted2022-12-09T13:43:20Z-
dc.identifier.citationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (21) (Art N° 13529)-
dc.identifier.urihttp://hdl.handle.net/1942/39061-
dc.description.abstractProlyl carboxypeptidase (PRCP) is involved in metabolic disorders by hydrolyzing anorexigenic peptides. A link between serum PRCP activity and obesity has been reported, but its origin/source is still unclear. Previously proven correlations between human serum PRCP activity and the amount of adipose tissue may suggest that adipose tissue is an important source of circulating PRCP. We investigated PRCP activity in visceral, subcutaneous adipose tissue (VAT and SCAT), skeletal muscle tissue and serum of lean and obese men with or without type 2 diabetes (T2D). Correlations between PRCP activity, metabolic and biochemical parameters and immune cell populations were assessed. PRCP activity was the highest in VAT, compared to SCAT, and was very low in skeletal muscle tissue in the overall group. Serum PRCP activity was significantly higher in T2-diabetic obese men, compared to lean and obese non-diabetic men, and was positively correlated with glycemic control. A positive correlation was observed between serum PRCP activity and VAT immune cell populations, which might indicate that circulating PRCP activity is deriving rather from the immune fraction than from adipocytes. In conclusion, PRCP activity was observed in human adipose tissue for the first time and serum PRCP activity is correlated with T2D in obese men.-
dc.description.sponsorshipThis research was funded by the Research Foundation Flanders (grant numbers FWO-SB 1S22417N and FWO-SBO S001017N) and by a GOA BOF 2015 grant of the University of Antwerp (No. 30729; www.uantwerp.be). Part of this work was supported by internal resources from Hasselt University. This study was financed by The Netherlands Organization for Scientific Research (NWO) (Veni 916.12.056), The Netherlands Heart Foundation (2013T143) and a Seventh Framework Program (FP7) Grant (CIG 322070). We thank University Biobank Limburg (UBiLim, Jessa Hospital, Belgium) for their technical support in sample handling and storage. Conflicts of Interest: The authors declare no conflict of interest.-
dc.language.isoen-
dc.publisherMDPI-
dc.rights2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).-
dc.subject.otherdiabetes-
dc.subject.otherhuman adipose tissue-
dc.subject.othermetabolic disorders-
dc.subject.otherobesity-
dc.subject.otherprolyl carboxypeptidase-
dc.titleProlyl Carboxypeptidase Activity Is Present in Human Adipose Tissue and Is Elevated in Serum of Obese Men with Type 2 Diabetes-
dc.typeJournal Contribution-
dc.identifier.issue21-
dc.identifier.volume23-
local.bibliographicCitation.jcatA1-
dc.description.notesDe Meester, I (corresponding author), Univ Antwerp, Lab Med Biochem, Fac Pharmaceut Biomed & Vet Sci, B-2610 Antwerp, Belgium.-
dc.description.notesingrid.demeester@uantwerpen.be-
local.publisher.placeST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr13529-
dc.identifier.doi10.3390/ijms232113529-
dc.identifier.pmid36362314-
dc.identifier.isi000885809000001-
dc.contributor.orcidWouters, Kristiaan/0000-0001-7127-6950; Verboven,-
dc.contributor.orcidKenneth/0000-0002-3799-5430-
local.provider.typewosris-
local.description.affiliation[De Hert, Emilie; De Meester, Ingrid] Univ Antwerp, Lab Med Biochem, Fac Pharmaceut Biomed & Vet Sci, B-2610 Antwerp, Belgium.-
local.description.affiliation[Verboven, Kenneth] Hasselt Univ, Fac Rehabil Sci, REVAL Rehabil Res Ctr, B-3590 Diepenbeek, Belgium.-
local.description.affiliation[Verboven, Kenneth] Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Ctr, B-3590 Diepenbeek, Belgium.-
local.description.affiliation[Wouters, Kristiaan] Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Dept Internal Med, Med Ctr, NL-6229 ER Maastricht, Netherlands.-
local.description.affiliation[Jocken, Johan W. E.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Dept Human Biol, Med Ctr, NL-6229 ER Maastricht, Netherlands.-
local.uhasselt.internationalyes-
item.fulltextWith Fulltext-
item.fullcitationDe Hert, Emilie; VERBOVEN, Kenneth; WOUTERS, Kristiaan; Jocken, Johan W. E. & De Meester, Ingrid (2022) Prolyl Carboxypeptidase Activity Is Present in Human Adipose Tissue and Is Elevated in Serum of Obese Men with Type 2 Diabetes. In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (21) (Art N° 13529).-
item.accessRightsOpen Access-
item.contributorDe Hert, Emilie-
item.contributorVERBOVEN, Kenneth-
item.contributorWOUTERS, Kristiaan-
item.contributorJocken, Johan W. E.-
item.contributorDe Meester, Ingrid-
item.validationecoom 2023-
crisitem.journal.issn1661-6596-
crisitem.journal.eissn1422-0067-
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