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http://hdl.handle.net/1942/39104
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DC Field | Value | Language |
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dc.contributor.author | Costa, Francesco | - |
dc.contributor.author | Montalto, Claudio | - |
dc.contributor.author | Branca, Mattia | - |
dc.contributor.author | Hong, Sung-Jin | - |
dc.contributor.author | Watanabe, Hirotoshi | - |
dc.contributor.author | Franzone, Anna | - |
dc.contributor.author | VRANCKX, Pascal | - |
dc.contributor.author | Hahn, Joo-Yong | - |
dc.contributor.author | Gwon, Hyeon-Cheol | - |
dc.contributor.author | Feres, Fausto | - |
dc.contributor.author | Jang, Yangsoo | - |
dc.contributor.author | De Luca, Giuseppe | - |
dc.contributor.author | Kedhi, Elvin | - |
dc.contributor.author | Cao, Davide | - |
dc.contributor.author | Steg, Philippe Gabriel | - |
dc.contributor.author | Bhatt, Deepak L. | - |
dc.contributor.author | Stone, Gregg W. | - |
dc.contributor.author | Micari, Antonio | - |
dc.contributor.author | Windecker, Stephan | - |
dc.contributor.author | Kimura, Takeshi | - |
dc.contributor.author | Hong, Myeong-Ki | - |
dc.contributor.author | Mehran, Roxana | - |
dc.contributor.author | Valgimigli, Marco | - |
dc.date.accessioned | 2023-01-03T08:16:23Z | - |
dc.date.available | 2023-01-03T08:16:23Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-12-23T13:54:06Z | - |
dc.identifier.citation | EUROPEAN HEART JOURNAL, 44 (11), p. 954-968 | - |
dc.identifier.uri | http://hdl.handle.net/1942/39104 | - |
dc.description.abstract | Aims The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in patients at high bleeding risk (HBR) is still debated. The current study, using the totality of existing evidence, evaluated the impact of an abbreviated DAPT regimen in HBR patients. Methods and results A systematic review and meta-analysis was performed to search randomized clinical trials comparing abbreviated [i.e. very-short (1 month) or short (3 months)] with standard (>= 6 months) DAPT in HBR patients without indication for oral anticoagulation. A total of 11 trials, including 9006 HBR patients, were included. Abbreviated DAPT reduced major or clinically relevant non-major bleeding [risk ratio (RR): 0.76, 95% confidence interval (CI): 0.61-0.94; I-2 = 28%], major bleeding (RR: 0.80, 95% CI: 0.64-0.99, I-2 = 0%), and cardiovascular mortality (RR: 0.79, 95% CI: 0.65-0.95, I-2 = 0%) compared with standard DAPT. No difference in all-cause mortality, major adverse cardiovascular events, myocardial infarction, or stent thrombosis was observed. Results were consistent, irrespective of HBR definition and clinical presentation. Conclusion In HBR patients undergoing PCI, a 1- or 3-month abbreviated DAPT regimen was associated with lower bleeding and cardiovascular mortality, without increasing ischaemic events, compared with a >= 6-month DAPT regimen. Study registration PROSPERO registration number CRD42021284004 | - |
dc.description.sponsorship | No funding was used for the current analysis. | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.rights | The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com | - |
dc.subject.other | Dual antiplatelet therapy | - |
dc.subject.other | High bleeding risk | - |
dc.subject.other | Percutaneous coronary intervention | - |
dc.subject.other | Aspirin | - |
dc.subject.other | Monotherapy | - |
dc.title | Dual antiplatelet therapy duration after percutaneous coronary intervention in high bleeding risk: a meta-analysis of randomized trials | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 968 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 954 | - |
dc.identifier.volume | 44 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Costa, F (corresponding author), Univ Messina, AOU Policlin G Martino, Dept Biomed & Dent Sci & Morphol & Funct Imaging, I-98100 Messina, Italy. | - |
dc.description.notes | fcosta@unime.it | - |
local.publisher.place | GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1093/eurheartj/ehac706 | - |
dc.identifier.pmid | 36477292 | - |
dc.identifier.isi | 000893552200001 | - |
dc.contributor.orcid | STEG, Philippe Gabriel/0000-0001-6896-2941; Hahn, | - |
dc.contributor.orcid | Joo-Yong/0000-0002-4412-377X | - |
local.provider.type | wosris | - |
local.description.affiliation | [Costa, Francesco; Micari, Antonio] Univ Messina, AOU Policlin G Martino, Dept Biomed & Dent Sci & Morphol & Funct Imaging, I-98100 Messina, Italy. | - |
local.description.affiliation | [Montalto, Claudio] Osped Niguarda Ca Granda, De Gasperis Cardio Ctr, Intervent Cardiol Unit, Milan, Italy. | - |
local.description.affiliation | [Branca, Mattia] Univ Bern, CTU Bern, Bern, Switzerland. | - |
local.description.affiliation | [Hong, Sung-Jin; Hong, Myeong-Ki] Yonsei Univ Hlth Syst, Severance Cardiovasc Hosp, Seoul, South Korea. | - |
local.description.affiliation | [Watanabe, Hirotoshi] Hirakata Kohsai Hosp, Dept Cardiol, Hirakata, Japan. | - |
local.description.affiliation | [Franzone, Anna] Federico II Univ Hosp, Dept Adv Biomed Sci, I-80131 Naples, Italy. | - |
local.description.affiliation | [Vranckx, Pascal] Univ Hasselt, Jessa Ziekenhuis, Fac Med & Life Sci, Dept Cardiol & Crit Care Med, Hasselt, Belgium. | - |
local.description.affiliation | [Hahn, Joo-Yong; Gwon, Hyeon-Cheol] Sungkyunkwan Univ, Sch Med, Heart Vasc Stroke Inst, Samsung Med Ctr, Seoul, South Korea. | - |
local.description.affiliation | [Feres, Fausto] Ist Dante Pazzanese Cardiol, Sao Paulo, Brazil. | - |
local.description.affiliation | [Jang, Yangsoo] CHA Bundang Med Ctr, Dept Cardiol, Dept Cardiol, Seongnam, South Korea. | - |
local.description.affiliation | [De Luca, Giuseppe] AOU Sassari, Clin & Expt Cardiol Unit, Sassari, Italy. | - |
local.description.affiliation | [Kedhi, Elvin] Univ Libre Bruxelles, Clin Hop Erasme, Brussels, Belgium. | - |
local.description.affiliation | [Cao, Davide] Humanitas Res Hosp IRCCS, Cardio Ctr, Milan, Italy. | - |
local.description.affiliation | [Steg, Philippe Gabriel] Univ Paris Cite, FACT, INSERM U1148, Paris, France. | - |
local.description.affiliation | [Steg, Philippe Gabriel] Hop Bichat Claude Bernard, AP HP, Paris, France. | - |
local.description.affiliation | [Bhatt, Deepak L.] Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA USA. | - |
local.description.affiliation | [Bhatt, Deepak L.] Harvard Med Sch, Boston, MA USA. | - |
local.description.affiliation | [Mehran, Roxana] Mt Sinai Hosp, Zena & Michael A Wiener Cardiovasc Inst, New York, NY USA. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2023 | - |
item.contributor | Costa, Francesco | - |
item.contributor | Montalto, Claudio | - |
item.contributor | Branca, Mattia | - |
item.contributor | Hong, Sung-Jin | - |
item.contributor | Watanabe, Hirotoshi | - |
item.contributor | Franzone, Anna | - |
item.contributor | VRANCKX, Pascal | - |
item.contributor | Hahn, Joo-Yong | - |
item.contributor | Gwon, Hyeon-Cheol | - |
item.contributor | Feres, Fausto | - |
item.contributor | Jang, Yangsoo | - |
item.contributor | De Luca, Giuseppe | - |
item.contributor | Kedhi, Elvin | - |
item.contributor | Cao, Davide | - |
item.contributor | Steg, Philippe Gabriel | - |
item.contributor | Bhatt, Deepak L. | - |
item.contributor | Stone, Gregg W. | - |
item.contributor | Micari, Antonio | - |
item.contributor | Windecker, Stephan | - |
item.contributor | Kimura, Takeshi | - |
item.contributor | Hong, Myeong-Ki | - |
item.contributor | Mehran, Roxana | - |
item.contributor | Valgimigli, Marco | - |
item.accessRights | Open Access | - |
item.fullcitation | Costa, Francesco; Montalto, Claudio; Branca, Mattia; Hong, Sung-Jin; Watanabe, Hirotoshi; Franzone, Anna; VRANCKX, Pascal; Hahn, Joo-Yong; Gwon, Hyeon-Cheol; Feres, Fausto; Jang, Yangsoo; De Luca, Giuseppe; Kedhi, Elvin; Cao, Davide; Steg, Philippe Gabriel; Bhatt, Deepak L.; Stone, Gregg W.; Micari, Antonio; Windecker, Stephan; Kimura, Takeshi; Hong, Myeong-Ki; Mehran, Roxana & Valgimigli, Marco (2022) Dual antiplatelet therapy duration after percutaneous coronary intervention in high bleeding risk: a meta-analysis of randomized trials. In: EUROPEAN HEART JOURNAL, 44 (11), p. 954-968. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0195-668X | - |
crisitem.journal.eissn | 1522-9645 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Dual Antiplatelet.pdf | Peer-reviewed author version | 546.4 kB | Adobe PDF | View/Open |
ehac706.pdf Restricted Access | Published version | 2 MB | Adobe PDF | View/Open Request a copy |
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