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http://hdl.handle.net/1942/39119
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DC Field | Value | Language |
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dc.contributor.author | VAN DE HATERD, Britt | - |
dc.contributor.author | VERBOVEN, Kenneth | - |
dc.contributor.author | VANDENABEELE, Frank | - |
dc.contributor.author | AGTEN, Anouk | - |
dc.date.accessioned | 2023-01-03T13:52:10Z | - |
dc.date.available | 2023-01-03T13:52:10Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2023-01-03T12:31:44Z | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (23) (Art N° 14833) | - |
dc.identifier.issn | - | |
dc.identifier.uri | http://hdl.handle.net/1942/39119 | - |
dc.description.abstract | Up to 60% of colorectal cancer (CRC) patients develop cachexia. The presence of CRC related cachexia is associated with more adverse events during systemic therapy, leading to a high mortality rate. The main manifestation in CRC related cachexia is the loss of skeletal muscle mass, resulting from an imbalance between skeletal muscle protein synthesis and protein degradation. In CRC related cachexia, systemic inflammation, oxidative stress, and proteolytic systems lead to mitochondrial dysfunction, resulting in an imbalanced skeletal muscle metabolism. Mitochondria fulfill an important function in muscle maintenance. Thus, preservation of the skeletal muscle mitochondrial homeostasis may contribute to prevent the loss of muscle mass. However, it remains elusive whether mitochondria play a benign or malignant role in the development of cancer cachexia. This review summarizes current (mostly preclinical) evidence about the role of skeletal muscle mitochondria in the development of CRC related cachexia. Future human research is necessary to determine the physiological role of skeletal muscle mitochondria in the development of human CRC related cachexia. | - |
dc.description.sponsorship | This research received no external funding. | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | - |
dc.subject.other | colorectal cancer | - |
dc.subject.other | skeletal muscle | - |
dc.subject.other | cachexia | - |
dc.subject.other | mitochondria | - |
dc.subject.other | inflammation | - |
dc.title | The Role of Skeletal Muscle Mitochondria in Colorectal Cancer Related Cachexia: Friends or Foes? | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 23 | - |
dc.identifier.volume | 23 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Vandenabeele, F (corresponding author), Hasselt Univ, Fac Rehabil Sci, REVAL Rehabil Res Ctr, B-3590 Diepenbeek, Belgium. | - |
dc.description.notes | frank.vandenabeele@uhasselt.be | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
local.bibliographicCitation.artnr | 14833 | - |
dc.identifier.doi | 10.3390/ijms232314833 | - |
dc.identifier.pmid | 36499157 | - |
dc.identifier.isi | 000896173800001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [van de Haterd, Britt; Verboven, Kenneth; Vandenabeele, Frank; Agten, Anouk] Hasselt Univ, Fac Rehabil Sci, REVAL Rehabil Res Ctr, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Verboven, Kenneth] Hasselt Univ, BIOMED Biomed Res Ctr, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Agten, Anouk] Hasselt Univ, Sch Educ Studies, U RISE Uhasselt Res Grp Innovat & Soc Engaged Educ, B-3590 Diepenbeek, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.fullcitation | VAN DE HATERD, Britt; VERBOVEN, Kenneth; VANDENABEELE, Frank & AGTEN, Anouk (2022) The Role of Skeletal Muscle Mitochondria in Colorectal Cancer Related Cachexia: Friends or Foes?. In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (23) (Art N° 14833). | - |
item.accessRights | Open Access | - |
item.validation | ecoom 2023 | - |
item.contributor | VAN DE HATERD, Britt | - |
item.contributor | VERBOVEN, Kenneth | - |
item.contributor | VANDENABEELE, Frank | - |
item.contributor | AGTEN, Anouk | - |
crisitem.journal.issn | 1661-6596 | - |
crisitem.journal.eissn | 1422-0067 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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The Role of Skeletal Muscle Mitochondria in Colorectal Cancer Related Cachexia_ Friends or Foes_.pdf | Published version | 912.65 kB | Adobe PDF | View/Open |
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