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http://hdl.handle.net/1942/39129
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DC Field | Value | Language |
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dc.contributor.author | VANHERLE, Sam | - |
dc.contributor.author | JORISSEN, Winde | - |
dc.contributor.author | DIERCKX, Tess | - |
dc.contributor.author | LOIX, Melanie | - |
dc.contributor.author | GRAJCHEN, Elien | - |
dc.contributor.author | MINGNEAU, Fleur | - |
dc.contributor.author | GUNS, Jeroen | - |
dc.contributor.author | GERVOIS, Pascal | - |
dc.contributor.author | LAMBRICHTS, Ivo | - |
dc.contributor.author | Dehairs, Jonas | - |
dc.contributor.author | Swinnen, Johannes, V | - |
dc.contributor.author | Mulder, Monique T. | - |
dc.contributor.author | Remaley, Alan T. | - |
dc.contributor.author | HAIDAR, Mansour | - |
dc.contributor.author | HENDRIKS, Jerome | - |
dc.contributor.author | BOGIE, Jeroen | - |
dc.date.accessioned | 2023-01-04T08:01:18Z | - |
dc.date.available | 2023-01-04T08:01:18Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2023-01-03T12:57:00Z | - |
dc.identifier.citation | Cell Reports, 41 (6) (Art N° 111591) | - |
dc.identifier.uri | http://hdl.handle.net/1942/39129 | - |
dc.description.abstract | The progressive nature of demyelinating diseases lies in the inability of the central nervous system (CNS) to induce proper remyelination. Recently, we and others demonstrated that a dysregulated innate immune response partially underlies failure of CNS remyelination. Extensive accumulation of myelin-derived lipids and an inability to process these lipids was found to induce a disease-promoting phagocyte phenotype. Hence, restoring the ability of these phagocytes to metabolize and efflux myelin-derived lipids represents a promising strategy to promote remyelination. Here, we show that ApoA-I mimetic peptide 5A, a molecule well known to promote activity of the lipid efflux transporter ABCA1, markedly enhances remyelination. Mechanistically, we find that the repair-inducing properties of 5A are attributable to increased clearance and metabolism of remyelination-inhibiting myelin debris via the fatty acid translocase protein CD36, which is transcriptionally controlled by the ABCA1-JAK2-STAT3 signaling pathway. Altogether, our findings indi-cate that 5A promotes remyelination by stimulating clearance and degradation of myelin debris. | - |
dc.description.sponsorship | We thank M.P. Tulleners for excellent technical assistance. The work was financially supported by the Research Foundation of Flanders (FWO Vlaanderen; 1S15519N, G099618FWO, and 12J9119N) and the Interreg V-A EMR program (EURLIPIDS, EMR23). The funding agencies had no role in the design, analysis, or writing of the article. | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.rights | 2022 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | - |
dc.title | The ApoA-I mimetic peptide 5A enhances remyelination by promoting clearance and degradation of myelin debris | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 6 | - |
dc.identifier.volume | 41 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Bogie, JJF (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, B-3590 Diepenbeek, Belgium.; Bogie, JJF (corresponding author), Univ MS Ctr Hasselt, B-3900 Pelt, Belgium. | - |
dc.description.notes | jeroen.bogie@uhasselt.be | - |
local.publisher.place | 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 111591 | - |
dc.identifier.doi | 10.1016/j.celrep.2022.111591 | - |
dc.identifier.isi | 000891242800004 | - |
dc.contributor.orcid | Guns, Jeroen/0000-0003-0464-2601 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Vanherle, Sam; Jorissen, Winde; Dierckx, Tess; Loix, Melanie; Grajchen, Elien; Mingneau, Fleur; Guns, Jeroen; Haidar, Mansour; Hendriks, Jerome J. A.; Bogie, Jeroen J. F.] Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Vanherle, Sam; Jorissen, Winde; Dierckx, Tess; Loix, Melanie; Grajchen, Elien; Mingneau, Fleur; Guns, Jeroen; Haidar, Mansour; Hendriks, Jerome J. A.; Bogie, Jeroen J. F.] Univ MS Ctr Hasselt, B-3900 Pelt, Belgium. | - |
local.description.affiliation | [Gervois, Pascal; Lambrichts, Ivo] Hasselt Univ, Biomed Res Inst, Dept Cardio & Organs Syst, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Dehairs, Jonas; Swinnen, Johannes, V] Univ Leuven, Leuven Canc Inst, Dept Oncol, Lab Lipid Metab & Canc, B-3000 Leuven, Belgium. | - |
local.description.affiliation | [Mulder, Monique T.] Erasmus MC, Dept Internal Med, NL-3015 Rotterdam, Netherlands. | - |
local.description.affiliation | [Remaley, Alan T.] NHLBI, Lipoprotein Metab Lab, Translat Vasc Med Branch, NIH, Bethesda, MD 20892 USA. | - |
local.uhasselt.international | yes | - |
item.accessRights | Open Access | - |
item.validation | ecoom 2023 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | VANHERLE, Sam; JORISSEN, Winde; DIERCKX, Tess; LOIX, Melanie; GRAJCHEN, Elien; MINGNEAU, Fleur; GUNS, Jeroen; GERVOIS, Pascal; LAMBRICHTS, Ivo; Dehairs, Jonas; Swinnen, Johannes, V; Mulder, Monique T.; Remaley, Alan T.; HAIDAR, Mansour; HENDRIKS, Jerome & BOGIE, Jeroen (2022) The ApoA-I mimetic peptide 5A enhances remyelination by promoting clearance and degradation of myelin debris. In: Cell Reports, 41 (6) (Art N° 111591). | - |
item.contributor | VANHERLE, Sam | - |
item.contributor | JORISSEN, Winde | - |
item.contributor | DIERCKX, Tess | - |
item.contributor | LOIX, Melanie | - |
item.contributor | GRAJCHEN, Elien | - |
item.contributor | MINGNEAU, Fleur | - |
item.contributor | GUNS, Jeroen | - |
item.contributor | GERVOIS, Pascal | - |
item.contributor | LAMBRICHTS, Ivo | - |
item.contributor | Dehairs, Jonas | - |
item.contributor | Swinnen, Johannes, V | - |
item.contributor | Mulder, Monique T. | - |
item.contributor | Remaley, Alan T. | - |
item.contributor | HAIDAR, Mansour | - |
item.contributor | HENDRIKS, Jerome | - |
item.contributor | BOGIE, Jeroen | - |
crisitem.journal.issn | 2211-1247 | - |
crisitem.journal.eissn | 2211-1247 | - |
Appears in Collections: | Research publications |
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The ApoA-I mimetic peptide 5A enhances remyelination by promoting clearance and degradation of myelin debris.pdf | Published version | 7.56 MB | Adobe PDF | View/Open |
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