Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/39175
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | COSEMANS, Charlotte | - |
dc.contributor.author | WANG, Congrong | - |
dc.contributor.author | MARTENS, Dries | - |
dc.contributor.author | JANSSEN, Bram | - |
dc.contributor.author | Vanpoucke, Charlotte | - |
dc.contributor.author | Lefebvre, Wouter | - |
dc.contributor.author | SMEETS, Karen | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | PLUSQUIN, Michelle | - |
dc.date.accessioned | 2023-01-09T08:26:46Z | - |
dc.date.available | 2023-01-09T08:26:46Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2023-01-05T12:02:47Z | - |
dc.identifier.citation | ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (1), p. 350-359 | - |
dc.identifier.uri | http://hdl.handle.net/1942/39175 | - |
dc.description.abstract | Mitochondria are sensitive to oxidative stress, which can be caused by traffic-related air pollution. Placental mitochondrial DNA (mtDNA) mutations have been previously linked with air pollution. However, the relationship between prenatal air pollution and cord-blood mtDNA mutations has been poorly understood. Therefore, we hypothesized that prenatal particulate matter (PM2.5) and NO2 exposures are associated with cord-blood mtDNA heteroplasmy. As part of the ENVIRONAGE cohort, 200 mother-newborn pairs were recruited. Cord-blood mitochondrial single-nucleotide polymorphisms were identified by whole mitochondrial genome sequencing, and heteroplasmy levels were evaluated based on the variant allele frequency (VAF). Outdoor PM2.5 and NO2 concentrations were determined by a high resolution spatial-temporal interpolation method based on the maternal residential address. Distributed lag linear models were used to determine sensitive time windows for the association between NO2 exposure and cord-blood mtDNA heteroplasmy. A 5 mu g/m3 increment in NO2 was linked with MT-D-Loop16311T>C heteroplasmy from gestational weeks 17-25. MT-CYTB14766C>T was negatively associated with NO2 exposure in mid pregnancy, from weeks 14-17, and positively associated in late pregnancy, from weeks 31-36. No significant associations were observed with prenatal PM2.5 exposure. This is the first study to show that prenatal NO2 exposure is associated with cord-blood mitochondrial mutations and suggests two critical windows of exposure in mid-to-late pregnancy. | - |
dc.description.sponsorship | The ENVIRONAGE birth cohort is supported by grants from the European Research Council (ERC-2012-StG310898), the Flemish Scientific Fund (FWO, 1516112 N/G.0873.11.N.10), and Kom op Tegen Kanker. C.C. was financially supported by the Centre for Environmental Sciences of Hasselt University. D.S.M. was financially supported by the FWO (12X9620N). The authors are extremely grateful to the participating women and neonates, as well as the staff of the maternity ward, midwives, the staff of the clinical laboratory of East-Limburg Hospital in Genk, and Martien Peusens and Dominika Tylus for the coordination between Hasselt University and EastLimburg Hospital. | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.rights | XXXX American Chemical Society | - |
dc.subject.other | mitochondria | - |
dc.subject.other | SNP | - |
dc.subject.other | heteroplasmy | - |
dc.subject.other | air pollution | - |
dc.subject.other | DLM | - |
dc.title | In Utero Exposure to Air Pollutants and Mitochondrial Heteroplasmy in Neonates | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 350 | - |
dc.identifier.volume | 57 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Plusquin, M (corresponding author), Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. | - |
dc.description.notes | michelle.plusquin@uhasselt.be | - |
local.publisher.place | 1155 16TH ST, NW, WASHINGTON, DC 20036 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 359 | - |
dc.identifier.doi | 10.1021/acs.est.2c02556 | - |
dc.identifier.isi | 000898882600001 | - |
dc.contributor.orcid | Plusquin, Michelle/0000-0002-7271-9722 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Cosemans, Charlotte; Wang, Congrong; Martens, Dries S.; Janssen, Bram G.; Smeets, Karen; Nawrot, Tim S.; Plusquin, Michelle] Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Vanpoucke, Charlotte] Belgian Interreg Environm Agcy, IRCEL CELINE, B-1000 Brussels, Belgium. | - |
local.description.affiliation | [Lefebvre, Wouter] VITO, Flemish Inst Technol Res, B-2400 Mol, Belgium. | - |
local.description.affiliation | [Nawrot, Tim S.] Leuven Univ, Sch Publ Hlth Occupat & Environm Med, B-3000 Leuven, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.fullcitation | COSEMANS, Charlotte; WANG, Congrong; MARTENS, Dries; JANSSEN, Bram; Vanpoucke, Charlotte; Lefebvre, Wouter; SMEETS, Karen; NAWROT, Tim & PLUSQUIN, Michelle (2022) In Utero Exposure to Air Pollutants and Mitochondrial Heteroplasmy in Neonates. In: ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (1), p. 350-359. | - |
item.accessRights | Open Access | - |
item.contributor | COSEMANS, Charlotte | - |
item.contributor | WANG, Congrong | - |
item.contributor | MARTENS, Dries | - |
item.contributor | JANSSEN, Bram | - |
item.contributor | Vanpoucke, Charlotte | - |
item.contributor | Lefebvre, Wouter | - |
item.contributor | SMEETS, Karen | - |
item.contributor | NAWROT, Tim | - |
item.contributor | PLUSQUIN, Michelle | - |
crisitem.journal.issn | 0013-936X | - |
crisitem.journal.eissn | 1520-5851 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
In Utero Exposure to Air Pollutants and Mitochondrial Heteroplasmy in Neonates.pdf Restricted Access | Published version | 1.75 MB | Adobe PDF | View/Open Request a copy |
In utero exposure.pdf | Peer-reviewed author version | 1.56 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.