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Title: | Dissecting the role of CSF2RB expression in human regulatory T cells | Authors: | FERNANDES CORTE-REAL, Beatriz ARROYO HORNERO, Rebeca DYCZKO, Aleksandra HAMAD, Ibrahim KLEINEWIETFELD, Markus |
Issue Date: | 2022 | Publisher: | FRONTIERS MEDIA SA | Source: | Frontiers in Immunology, 13 (Art N° 1005965) | Abstract: | Colony stimulating factor 2 receptor subunit beta (CSF2RB; CD131) is the common subunit of the type I cytokine receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3 and IL-5. Interestingly, FOXP3(+) regulatory T cells (Tregs), which play a pivotal role in prevention of autoimmunity have been demonstrated to highly overexpress CSF2RB and genome-wide association studies (GWAS) identified CSF2RB as being linked to autoimmune diseases like multiple sclerosis (MS). However, the exact biological role of CD131 in human Tregs has not been defined yet. Here we investigated CD131 importance on Treg phenotype and function in a broad range of in vitro studies. Although we could not recognize a specific function of CSF2RB; CD131 in human Tregs, our data show that CD131 expression is vastly restricted to Tregs even under stimulatory conditions, indicating that CD131 could aid as a potential marker to identify Treg subpopulations from pools of activated CD4(+) T cells. Importantly, our analysis further demonstrate the overexpression of CSF2RB in Tregs of patients with autoimmune diseases like MS and systemic lupus erythematosus (SLE) in comparison to healthy controls, thereby indicating that CSF2RB expression in Tregs could serve as a potential novel biomarker for disease. | Notes: | Kleinewietfeld, M (corresponding author), Hasselt Univ VIB VIB, Ctr Inflammat Res IRC, Lab Translat Immunomodulat, Vlaams Inst Biotechnol VIB, Diepenbeek, Belgium.; Kleinewietfeld, M (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol, Diepenbeek, Belgium.; Kleinewietfeld, M (corresponding author), Hasselt Univ UHasselt Campus, Univ Mulpitle Sclerosis Ctr UMSC, Diepenbeek, Belgium. markus.kleinewietfeld@uhasselt.vib.be |
Keywords: | CSF2RB;CD4+T cells;FOXP3+Tregs;autoimmunity;MS | Document URI: | http://hdl.handle.net/1942/39192 | ISSN: | 1664-3224 | e-ISSN: | 1664-3224 | DOI: | 10.3389/fimmu.2022.1005965 | ISI #: | 000899046100001 | Rights: | 2022 Coˆ rte-Real, Arroyo Hornero, Dyczko, Hamad and Kleinewietfeld. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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