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http://hdl.handle.net/1942/3926
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DC Field | Value | Language |
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dc.contributor.author | Maes, Michael | - |
dc.contributor.author | BOSMANS, E | - |
dc.contributor.author | SUY, E | - |
dc.contributor.author | MINNER, B | - |
dc.contributor.author | RAUS, Jef | - |
dc.date.accessioned | 2007-11-30T07:48:05Z | - |
dc.date.available | 2007-11-30T07:48:05Z | - |
dc.date.issued | 1991 | - |
dc.identifier.citation | PSYCHOLOGICAL MEDICINE, 21(2). p. 313-320 | - |
dc.identifier.issn | 0033-2917 | - |
dc.identifier.uri | http://hdl.handle.net/1942/3926 | - |
dc.description.abstract | In order to investigate the relationship between the immune apparatus and the hypothalamic-pituitary-adrenal (HPA)-axis activity in depressed patients, we measured in vitro lymphocyte responses to the mitogens Phytohaemagglutinin (PHA), Pokeweed (PWM) and Concanavalin A (Con A) and 8 a.m. baseline cortisol values in plasma, free cortisol excretion in 24 h urine (UFC), basal and post-dexamethasone beta-endorphin values. Major depressed patients with melancholia/psychotic features exhibited a significantly lower mitogen-induced blast transformation as compared to minor and simple major depressed patients. The lymphocyte responses to the three mitogens were significantly inversely related to baseline cortisol values and postdexamethasone beta-endorphin values. The proliferative capacity of lymphocytes to stimulation with PHA and PWM was significantly and positively related to UFC excretion. Up to 45 % of the variance in the immune responses to the mitogens was explained by the baseline cortisol, postdexamethasone beta-endorphin and UFC values. | - |
dc.language.iso | en | - |
dc.publisher | CAMBRIDGE UNIV PRESS | - |
dc.title | A further exploration of the relationships between immune parameters and the hpa-axis activity in depressed-patients | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 320 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 313 | - |
dc.identifier.volume | 21 | - |
local.format.pages | 8 | - |
dc.description.notes | DR WILLEMS INST,DIEPENBEEK,BELGIUM.MAES, M, PSYCHIAT CTR WEYBURN,ABDIJSTR 2,B-3751 MUNSTERBILZEN,BELGIUM. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.isi | A1991FR87300006 | - |
item.fullcitation | Maes, Michael; BOSMANS, E; SUY, E; MINNER, B & RAUS, Jef (1991) A further exploration of the relationships between immune parameters and the hpa-axis activity in depressed-patients. In: PSYCHOLOGICAL MEDICINE, 21(2). p. 313-320. | - |
item.fulltext | No Fulltext | - |
item.contributor | Maes, Michael | - |
item.contributor | BOSMANS, E | - |
item.contributor | SUY, E | - |
item.contributor | MINNER, B | - |
item.contributor | RAUS, Jef | - |
item.accessRights | Closed Access | - |
Appears in Collections: | Research publications |
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