Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/39273
Title: | Regulatory T cell therapy for multiple sclerosis: Breaching (blood-brain) barriers | Authors: | Verreycken, Janne BAETEN, Paulien BROUX, Bieke |
Issue Date: | 2022 | Publisher: | TAYLOR & FRANCIS INC | Source: | Human Vaccines & Immunotherapeutics, 18 (7) (Art N° e2153534) | Abstract: | Multiple sclerosis (MS) is an autoimmune disorder causing demyelination and neurodegeneration in the central nervous system. MS is characterized by disturbed motor performance and cognitive impairment. Current MS treatments delay disease progression and reduce relapse rates with general immunomodulation, yet curative therapies are still lacking. Regulatory T cells (Tregs) are able to suppress autoreactive immune cells, which drive MS pathology. However, Tregs are functionally impaired in people with MS. Interestingly, Tregs were recently reported to also have regenerative capacity. Therefore, experts agree that Treg cell therapy has the potential to ameliorate the disease. However, to perform their local anti-inflammatory and regenerative functions in the brain, they must first migrate across the blood-brain barrier (BBB). This review summarizes the reported results concerning the migration of Tregs across the BBB and the influence of Tregs on migration of other immune subsets. Finally, their therapeutic potential is discussed in the context of MS. | Notes: | Broux, B (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Neuroimmune Connect & Repair Lab, Martelarenlaan 42, B-3500 Diepenbeek, Belgium. bieke.broux@uhasselt.be |
Keywords: | Regulatory T cells;multiple sclerosis;blood-brain barrier;diapedesis;regulatory T cell therapy | Document URI: | http://hdl.handle.net/1942/39273 | ISSN: | 2164-5515 | e-ISSN: | 2164-554X | DOI: | 10.1080/21645515.2022.2153534 | ISI #: | 000905397000001 | Rights: | 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Regulatory T cell therapy for multiple sclerosis_ Breaching (blood-brain) barriers.pdf | Published version | 2.64 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.