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http://hdl.handle.net/1942/39282
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DC Field | Value | Language |
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dc.contributor.author | Moreel, Lien | - |
dc.contributor.author | Betrains, Albrecht | - |
dc.contributor.author | MOLENBERGHS, Geert | - |
dc.contributor.author | Vanderschueren, Steven | - |
dc.contributor.author | Blockmans, Daniel | - |
dc.date.accessioned | 2023-01-23T12:05:46Z | - |
dc.date.available | 2023-01-23T12:05:46Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-01-12T14:55:07Z | - |
dc.identifier.citation | JOINT BONE SPINE, 90 (1) (Art N° 105494) | - |
dc.identifier.uri | http://hdl.handle.net/1942/39282 | - |
dc.description.abstract | Objectives: The aim of this study was to estimate the timing of relapse, the prevalence of multiple relapses and the predictors of relapse in patients with giant cell arteritis (GCA).Methods: PubMed, Embase and Cochrane databases were searched from inception till November, 30 2021. Outcome measures include cumulative relapse rate (CRR) of first relapse at year 1, 2, and 5 after treatment initiation, CRR of second and third relapse and predictors of relapse. Results: Thirty studies (2595 patients) were included for timing of relapse, 16 studies (1947 patients) for prevalence of multiple relapses and 40 studies (4213 patients) for predictors of relapse. One-year, 2-year and 5-year CRRs were 32% [95% confidence interval (CI) 22-43%], 44% [95% CI 31-59%], and 47% [95% CI 27-67%], respectively. The duration of scheduled glucocorticoid therapy was negatively associated with the 1-year CRR (P = 0.03). CRR of second and third relapse were 30% [95% CI 21-40] and 17% [95% CI 8-33%], respectively. Female sex (OR 1.43) and large vessel involvement (OR 2.04) were predictors of relapse.Conclusion: Relapse occurred in almost half of GCA patients mainly during the first two years after diagnosis. One in three patients had multiple relapses. The optimal glucocorticoid tapering schedule, which seeks a balance between the lowest relapse risk and the shortest glucocorticoid duration, needs to be determined in future studies. Longer scheduled glucocorticoid therapy or early introduction of glucocorticoid-sparing agents may be warranted in female patients and patients with large vessel involve-ment.(c) 2022 Societe franc , aise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved. | - |
dc.description.sponsorship | This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.rights | 2022 Societ´ e´ franc¸ aise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved. | - |
dc.subject.other | Giant cell arteritis | - |
dc.subject.other | GCA | - |
dc.subject.other | Relapse | - |
dc.title | Epidemiology and predictors of relapse in giant cell arteritis: A systematic review and meta-analysis | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 1 | - |
dc.identifier.volume | 90 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Moreel, L (corresponding author), Univ Hosp Leuven, Gen Internal Med Dept, Herestr 49, B-3000 Leuven, Belgium. | - |
dc.description.notes | Lien.Moreel@uzleuven.be | - |
local.publisher.place | 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
local.bibliographicCitation.artnr | 105494 | - |
dc.identifier.doi | 10.1016/j.jbspin.2022.105494 | - |
dc.identifier.pmid | 36410684 | - |
dc.identifier.isi | 000902129000002 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Moreel, Lien; Betrains, Albrecht; Vanderschueren, Steven; Blockmans, Daniel] Univ Hosp Leuven, Dept Gen Internal Med, Leuven, Belgium. | - |
local.description.affiliation | [Moreel, Lien; Betrains, Albrecht; Vanderschueren, Steven; Blockmans, Daniel] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Leuven, Belgium. | - |
local.description.affiliation | [Molenberghs, Geert] Univ Leuven, Interuniv Inst Biostat & Stat Bioinformat I BioSta, Leuven, Belgium. | - |
local.description.affiliation | [Molenberghs, Geert] Hasselt Univ, Leuven, Belgium. | - |
local.description.affiliation | [Vanderschueren, Steven; Blockmans, Daniel] European Reference Network Immunodeficiency Autoin, Leuven, Belgium. | - |
local.description.affiliation | [Moreel, Lien] Univ Hosp Leuven, Gen Internal Med Dept, Herestr 49, B-3000 Leuven, Belgium. | - |
local.uhasselt.international | no | - |
item.fullcitation | Moreel, Lien; Betrains, Albrecht; MOLENBERGHS, Geert; Vanderschueren, Steven & Blockmans, Daniel (2023) Epidemiology and predictors of relapse in giant cell arteritis: A systematic review and meta-analysis. In: JOINT BONE SPINE, 90 (1) (Art N° 105494). | - |
item.fulltext | With Fulltext | - |
item.contributor | Moreel, Lien | - |
item.contributor | Betrains, Albrecht | - |
item.contributor | MOLENBERGHS, Geert | - |
item.contributor | Vanderschueren, Steven | - |
item.contributor | Blockmans, Daniel | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 1297-319X | - |
crisitem.journal.eissn | 1778-7254 | - |
Appears in Collections: | Research publications |
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Epidemiology and predictors of relapse in giant cell arteritis_ A systematic review and meta-analysis.pdf Restricted Access | Published version | 3.39 MB | Adobe PDF | View/Open Request a copy |
Epidemiology and predictors of relapse in giant cell arteritis_ a systematic review and meta-analysis.pdf | Peer-reviewed author version | 732.36 kB | Adobe PDF | View/Open |
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