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Title: | Severe coronary artery spasm after administration of a 5-hydroxytryptamine type 1 receptor agonist in a patient with new-onset Graves' disease and myocarditis after SARS-CoV2 vaccination | Authors: | Vandebosch, Charis DUPONT, Matthias Verhaert, David MULLENS, Wilfried |
Issue Date: | 2023 | Publisher: | TAYLOR & FRANCIS LTD | Source: | ACTA CARDIOLOGICA, 78 (8), p. 889-893 | Abstract: | Background: Coronary artery spasm is a well-known potential side effect of selective 5-hydroxytryptamine type 1 (5HT1) receptor agonists and, therefore, contraindicated in patients with cardiovascular disease. SARS-CoV-2 vaccination has been associated with myocarditis, mainly in young men.Case summary: A 55-year-old man with longstanding cluster headache, treated with the 5HT1-agonist Sumatriptan for ten years, received the mRNA-1273 SARS-CoV-2 booster vaccine. Four days later, he developed severe retrosternal pain several minutes after administering Sumatriptan with electrographic ST-elevation and a raised high-sensitivity cardiac troponin-T (hs-cTnT). Coronary angiogram was normal, but a diagnosis of acute myocarditis and hyperthyroidism secondary to Graves' disease was made.Discussion: We present a case of severe coronary artery spasm induced by a 5HT1-agonist secondary to newly diagnosed Graves' disease and myocarditis. The mRNA-1273 SARS-CoV-2 booster vaccine administered four days before admission probably triggered both immunoreactions. | Notes: | Vandebosch, C (corresponding author), Hosp Oost Limburg, Dept Cardiol, Genk, Limburg, Belgium. charis_vdb@hotmail.com |
Keywords: | Coronary artery spasm;ST-elevation;selective 5-hydroxytryptamine type 1 receptor agonist;myocarditis;Graves' disease;SARS-CoV-2 vaccination | Document URI: | http://hdl.handle.net/1942/39353 | ISSN: | 0001-5385 | e-ISSN: | 1784-973X | DOI: | 10.1080/00015385.2022.2135224 | ISI #: | 000907513000001 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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