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http://hdl.handle.net/1942/39435
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DC Field | Value | Language |
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dc.contributor.author | MARTENS, Pieter | - |
dc.contributor.author | Hanna, Mazen | - |
dc.contributor.author | Valent, Jason | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | Ives, Lauren | - |
dc.contributor.author | Kwon, Debbie H. | - |
dc.contributor.author | Rickard, John | - |
dc.contributor.author | Tang, W. H. Wilson | - |
dc.date.accessioned | 2023-02-15T09:49:04Z | - |
dc.date.available | 2023-02-15T09:49:04Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2023-02-13T13:36:35Z | - |
dc.identifier.citation | JOURNAL OF CARDIAC FAILURE, 28 (12) , p. 1664 -1672 | - |
dc.identifier.uri | http://hdl.handle.net/1942/39435 | - |
dc.description.abstract | Background: Conduction-system involvement in cardiac amyloidosis (CA) is common. The prevalence, clinical correlates and impact on outcome related to ventricular electrical dyssynchrony in CA remain insufficiently elucidated. Methods: Data from a prospectively maintained registry of patients with CA diagnosed in the Cleveland Clinic's amyloidosis clinic was used to determine the frequency of electrical dyssynchrony (defined as a QRS > 130 msec). The relation with the clinical profile and clinical outcome was assessed. To determine the impact of hypertrophy on QRS prolongation, a QRSmatched cohort without CA was used for comparison of cardiac magnetic resonance imaging. Results: A total of 1140 patients with CA (39% AL, 61% TTR) were evaluated, of whom 230 (20%) had electrical dyssynchrony. The type of conduction block was predominantly a right bundle branch block (BBB, 48%) followed by left BBB (35%) and intraventricular conduction delay (17%). Presence of transthyretin amyloidosis (ATTR-CA), older age, male gender, white race, and coronary artery disease were independently (P< 0.05 for all) associated with electrical dyssynchrony, and patients were more commonly prescribed a mineralocorticoid receptor antagonist. In ATTR-CA, specifically, every increase in ATTR-CA disease stage was associated with a 1.55-fold (1.23-1.95; P< 0.001) increased odds for electrical dyssynchrony. In a subset of patients with CA who underwent cardiac magnetic resonance imaging (n = 41), left ventricular mass index was unrelated to the QRS duration (r = 0.187; P = 0.283) in CA, in contrast to a nonCA QRS-matched cohort (r = 0.397; P< 0.001). Patients with electrical dyssynchrony were more symptomatic at initial presentation, as illustrated by a higher New York Heart Association class (P= 0.041). During a median follow-up of 462 days (IQR:138-996 days), a higher proportion of patients with electrical dyssynchrony died from all-cause death (P= 0.037) or developed a permanent pacing indication (3% vs 10.4%; P< 0.001) during follow-up. Conclusion: Electrical dyssynchrony is common in CA, especially in ATTR-CA, and is associated with worse functional status and clinical outcome. Given the high rate of permanent pacing indications at follow-up, additional studies are necessary to determine the best monitoring and pacing strategies in CA. (J Cardiac Fail 2022;28:1664-1672) | - |
dc.description.sponsorship | The Cleveland Clinic Amyloidosis Registry is supported by Dr. Hanna’s Term Chair for Amyloid Heart Disease. Dr. Pieter Martens is supported by a grant from the Belgian American Educational Foundation and by the Frans Van de Werf Fund. | - |
dc.language.iso | en | - |
dc.publisher | CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS | - |
dc.rights | 2022 Elsevier Inc. All rights reserved | - |
dc.subject.other | Cardiac amyloidosis | - |
dc.subject.other | Cardiac amyloidosis | - |
dc.subject.other | electrical dyssynchrony | - |
dc.subject.other | electrical dyssynchrony | - |
dc.subject.other | disease severity | - |
dc.subject.other | disease severity | - |
dc.subject.other | natural history | - |
dc.subject.other | natural history | - |
dc.title | Electrical Dyssynchrony in Cardiac Amyloidosis: Prevalence, Predictors, Clinical Correlates, and Outcomes | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1672 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 1664 | - |
dc.identifier.volume | 28 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Martens, P (corresponding author), Cleveland Clin, Heart Vasc & Thorac Inst, Dept Cardiovasc Med, Cleveland, OH 44195 USA.; Martens, P (corresponding author), Ziekenhuis Oost Limburg, Dept Cardiol, Genk, Belgium.; Martens, P (corresponding author), Univ Hasselt, Hasselt, Belgium. | - |
dc.description.notes | pieter_martens@icloud.com | - |
local.publisher.place | CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.cardfail.2022.07.046 | - |
dc.identifier.pmid | 35882259 | - |
dc.identifier.isi | 000905073900004 | - |
dc.contributor.orcid | Martens, Pieter/0000-0002-6036-2113 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Martens, Pieter; Hanna, Mazen; Ives, Lauren; Kwon, Debbie H.; Rickard, John; Tang, W. H. Wilson] Cleveland Clin, Heart Vasc & Thorac Inst, Dept Cardiovasc Med, Cleveland, OH 44195 USA. | - |
local.description.affiliation | [Martens, Pieter; Mullens, Wilfried] Ziekenhuis Oost Limburg, Dept Cardiol, Genk, Belgium. | - |
local.description.affiliation | [Martens, Pieter; Mullens, Wilfried] Univ Hasselt, Hasselt, Belgium. | - |
local.description.affiliation | [Valent, Jason] Cleveland Clin, Taussig Canc Inst, Dept Hematol & Med Oncol, Cleveland, OH USA. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.fullcitation | MARTENS, Pieter; Hanna, Mazen; Valent, Jason; MULLENS, Wilfried; Ives, Lauren; Kwon, Debbie H.; Rickard, John & Tang, W. H. Wilson (2022) Electrical Dyssynchrony in Cardiac Amyloidosis: Prevalence, Predictors, Clinical Correlates, and Outcomes. In: JOURNAL OF CARDIAC FAILURE, 28 (12) , p. 1664 -1672. | - |
item.contributor | MARTENS, Pieter | - |
item.contributor | Hanna, Mazen | - |
item.contributor | Valent, Jason | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | Ives, Lauren | - |
item.contributor | Kwon, Debbie H. | - |
item.contributor | Rickard, John | - |
item.contributor | Tang, W. H. Wilson | - |
crisitem.journal.issn | 1071-9164 | - |
crisitem.journal.eissn | 1532-8414 | - |
Appears in Collections: | Research publications |
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Electrical Dyssynchrony in Cardiac Amyloidosis_ Prevalence, Predictors, Clinical Correlates, and Outcomes.pdf Restricted Access | Published version | 789.47 kB | Adobe PDF | View/Open Request a copy |
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