Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/3944
Title: | Decreased serum dipeptidyl peptidase IV activity in major depression | Authors: | Maes, Michael DEMEESTER, I SCHARPE, S BOSMANS, E VANDERVORST, Carine RAUS, Jef MINNER, B SUY, E VANHOOF, G VERKERK, R |
Issue Date: | 1991 | Publisher: | ELSEVIER SCIENCE INC | Source: | BIOLOGICAL PSYCHIATRY, 30(6). p. 577-586 | Abstract: | It has been recently shown that severe depression is characterized by immune dysfunctions such as blunted mitogen-induced blast transformation, which is linked to interleukin-2 (IL-2) mechanisms, and to autoimmune responses. In order to explore one of the putative pathophysiological mechanisms underlying both factors, we have measured the predexamethasone and postdexamethasone serum dipeptidyl-peptidase IV (DPP IV) activity in depressed inpatients and normal controls. This enzyme is an important mediator of IL-2-related blast proliferation, and it may play a role in autoimmunity. We found significantly lower DPP IV levels in major depressives as compared with healthy controls, and melancholics exhibited significantly lower enzyme activity than minor depressives. There was a significant negative correlation between serum DPP IV activity and the severity of illness. However, we were unable to detect any significant relationships between DPP IV on the one hand, and mitogen-induced blast transformation, soluble IL-2 receptor accumulation in PHA culture supernatant, total number of leukocytes and lymphocytes, T lymphocytes, CD4+ and CD25+ cells, on the other. Men exhibited significantly higher serum DPP IV levels than women. | Notes: | UNIV INSTELLING ANTWERP,DEPT NEUROCHEM,B-2610 WILRIJK,BELGIUM. EUROGENET,TESSENDERLOO,BELGIUM. UNIV DIEPENBEEK,WILLEMS INST,DIEPENBEEK,BELGIUM.MAES, M, PSYCHIAT CTR ST JOSEF,ABDIJSTR 2,B-3751 MUNSTERBILZEN,BELGIUM. | Document URI: | http://hdl.handle.net/1942/3944 | ISSN: | 0006-3223 | e-ISSN: | 1873-2402 | DOI: | 10.1016/0006-3223(91)90027-J | ISI #: | A1991GF82100005 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Show full item record
SCOPUSTM
Citations
54
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
56
checked on Sep 12, 2024
Page view(s)
84
checked on Oct 30, 2023
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.