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http://hdl.handle.net/1942/39443
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DC Field | Value | Language |
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dc.contributor.author | GHASEMIAN SHIRVAN, Ensiyeh | - |
dc.contributor.author | Ungureanu, Ruxandra | - |
dc.contributor.author | Melo, Lorena | - |
dc.contributor.author | VAN DUN, Kim | - |
dc.contributor.author | Kuo, Min-Fang | - |
dc.contributor.author | Nitsche, Michael A. | - |
dc.contributor.author | MEESEN, Raf | - |
dc.date.accessioned | 2023-02-15T10:38:06Z | - |
dc.date.available | 2023-02-15T10:38:06Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-02-13T13:38:10Z | - |
dc.identifier.citation | Brain Sciences, 13 (1) (Art N° 137) | - |
dc.identifier.uri | http://hdl.handle.net/1942/39443 | - |
dc.description.abstract | One of the most visible effects of aging, even in healthy, normal aging, is a decline in motor performance. The range of strategies applicable to counteract this deterioration has increased. Transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique that can promote neuroplasticity, has recently gained attention. However, knowledge about optimized tDCS parameters in the elderly is limited. Therefore, in this study, we investigated the effect of different anodal tDCS intensities on motor sequence learning in the elderly. Over the course of four sessions, 25 healthy older adults (over 65 years old) completed the Serial Reaction Time Task (SRTT) while receiving 1, 2, or 3 mA of anodal or sham stimulation over the primary motor cortex (M1). Additionally, 24 h after stimulation, motor memory consolidation was assessed. The results confirmed that motor sequence learning in all tDCS conditions was maintained the following day. While increased anodal stimulation intensity over M1 showed longer lasting excitability enhancement in the elderly in a prior study, the combination of higher intensity stimulation with an implicit motor learning task showed no significant effect. Future research should focus on the reason behind this lack of effect and probe alternative stimulation protocols. | - |
dc.description.sponsorship | We thank Nicole Rück and master students for their kind help in recruiting elderly participants in Germany and Belgium, respectively. We really appreciate our colleagues: Tobias Blanke, Tobias Klimek, Nina Abich, Mohsen Mosayebi-Samani in Germany and Mark Geraerts in Belgium for their technical support to build up the experimental setup. We are grateful to Klaus Golka and Jan G. Hengstler for medical screening of participants, and Hannah Schade and Benedikt Glinski for their help with psychological test assessment. | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/) | - |
dc.subject.other | tDCS | - |
dc.subject.other | implicit motor learning | - |
dc.subject.other | neuroplasticity | - |
dc.subject.other | healthy aging | - |
dc.title | Optimizing the Effect of tDCS on Motor Sequence Learning in the Elderly | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 1 | - |
dc.identifier.volume | 13 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Meesen, RLJ (corresponding author), Hasselt Univ, Fac Rehabil Sci, REVAL Rehabil Res Ctr, Neuroplast & Movement Control Res Grp,REVAL, B-3590 Diepenbeek, Belgium.; Meesen, RLJ (corresponding author), Katholieke Univ Leuven, Dept Movement Sci, Movement Control & Neuroplast Res Grp, Grp Biomed Sci, B-3001 Leuven, Belgium. | - |
dc.description.notes | raf.meesen@uhasselt.be | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 137 | - |
dc.identifier.doi | 10.3390/brainsci13010137 | - |
dc.identifier.pmid | 36672118 | - |
dc.identifier.isi | 000914621500001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Ghasemian-Shirvan, Ensiyeh; Ungureanu, Ruxandra; Melo, Lorena; Kuo, Min-Fang; Nitsche, Michael A.] Leibniz Res Ctr Working Environm & Human Factors, Dept Psychol & Neurosci, D-44139 Dortmund, Germany. | - |
local.description.affiliation | [Ghasemian-Shirvan, Ensiyeh; Melo, Lorena] Ruhr Univ Bochum, Int Grad Sch Neurosci, D-44780 Bochum, Germany. | - |
local.description.affiliation | [Ghasemian-Shirvan, Ensiyeh; van Dun, Kim; Meesen, Raf L. J.] Hasselt Univ, Fac Rehabil Sci, REVAL Rehabil Res Ctr, Neuroplast & Movement Control Res Grp,REVAL, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Ungureanu, Ruxandra] Ruhr Univ Bochum, Inst Cognit Neurosci, D-44801 Bochum, Germany. | - |
local.description.affiliation | [Nitsche, Michael A.] Bielefeld Univ, Univ Clin Psychiat & Psychotherapy, Univ Hosp OWL, Protestant Hosp Bethel Fdn, D-33617 Bielefeld, Germany. | - |
local.description.affiliation | [Nitsche, Michael A.] Bielefeld Univ, Univ Clin Child & Adolescent Psychiat & Psychother, Univ Hosp OWL, Protestant Hosp Bethel Fdn, D-33617 Bielefeld, Germany. | - |
local.description.affiliation | [Meesen, Raf L. J.] Katholieke Univ Leuven, Dept Movement Sci, Movement Control & Neuroplast Res Grp, Grp Biomed Sci, B-3001 Leuven, Belgium. | - |
local.uhasselt.international | yes | - |
item.fullcitation | GHASEMIAN SHIRVAN, Ensiyeh; Ungureanu, Ruxandra; Melo, Lorena; VAN DUN, Kim; Kuo, Min-Fang; Nitsche, Michael A. & MEESEN, Raf (2023) Optimizing the Effect of tDCS on Motor Sequence Learning in the Elderly. In: Brain Sciences, 13 (1) (Art N° 137). | - |
item.contributor | GHASEMIAN SHIRVAN, Ensiyeh | - |
item.contributor | Ungureanu, Ruxandra | - |
item.contributor | Melo, Lorena | - |
item.contributor | VAN DUN, Kim | - |
item.contributor | Kuo, Min-Fang | - |
item.contributor | Nitsche, Michael A. | - |
item.contributor | MEESEN, Raf | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.eissn | 2076-3425 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Optimizing the Effect of tDCS on Motor Sequence Learning in the Elderly.pdf | Published version | 1.59 MB | Adobe PDF | View/Open |
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