Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3951
Title: COEXISTING DYSREGULATIONS OF BOTH THE SYMPATHOADRENAL SYSTEM AND HYPOTHALAMIC-PITUITARY-ADRENAL-AXIS IN MELANCHOLIA
Authors: Maes, Michael
MINNER, B
SUY, E
VANDERVORST, Carine 
RAUS, Jef 
Issue Date: 1991
Publisher: SPRINGER-VERLAG WIEN
Source: JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION, 85(3). p. 195-210
Abstract: In order to delineate putatively coexisting dysregulations between sympathoadrenal system and hypothalamic-pituitary-adrenal (HPA)-axis during depression, the authors measured the following: the pre and postdexamethasone (1 mg) 24 hr urine excretion of noradrenaline, dopamine, adrenaline, 3-methoxy-4-hydroxyphenylglycol (MHPG), free cortisol (UFC), and plasma cortisol. Melancholic patients were characterized by a significantly higher excretion of noradrenaline, dopamine and adrenaline, combined with significantly increased UFC, postdexamethasone plasma cortisol, and UFC values. We found significant and positive correlations between UFC on the one hand, and the 24 hr urine excretion of noradrenaline, dopamine, and adrenaline, on the other. By the same token, we established significant relationships between the 24 hr urine excretion of those catecholamines and the postdexamethasone UFC and plasma cortisol values. Cortisol nonsuppressors exhibited a significantly higher excretion of noradrenaline, dopamine and adrenaline, as compared with cortisol suppressors. Dexamethasone administration did not have a significant effect on the urinary output of noradrenaline, dopamine, adrenaline or MHPG.
Notes: UNIV DIEPENBEEK,DR WILLEMS INST,DIEPENBEEK,BELGIUM.MAES, M, PSYCHIAT CTR WEYBURN,ST JOZEF ABDIJSTR 2,B-3751 MUNSTERBILZEN,BELGIUM.
Keywords: DEPRESSION; CATECHOLAMINES; 3-METHOXY-4-HYDROXYPHENYLGLYCOL; HYPOTHALAMIC-PITUITARY-ADRENAL-AXIS; DEXAMETHASONE SUPPRESSION TEST; URINARY FREE CORTISOL; PATHWAY ANALYSIS
Document URI: http://hdl.handle.net/1942/3951
DOI: 10.1007/BF01244945
ISI #: A1991GA11200003
Type: Journal Contribution
Appears in Collections:Research publications

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