Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/39546
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dc.contributor.authorFerrucci, Luigi-
dc.contributor.authorWILSON, David-
dc.contributor.authorDonega, Stefano-
dc.contributor.authorGorospe, Myriam-
dc.date.accessioned2023-02-21T10:55:05Z-
dc.date.available2023-02-21T10:55:05Z-
dc.date.issued2022-
dc.date.submitted2023-02-20T13:13:59Z-
dc.identifier.citationNature aging, 2 (3) , p. 182 -185-
dc.identifier.urihttp://hdl.handle.net/1942/39546-
dc.description.abstractAging can be conceptualized as the stochastic accumulation of damage and loss of resilience leading to organism demise. Resilience mechanisms that repair, recycle or replace damaged molecules and organelles are energy-demanding, therefore energy availability is essential to healthy aging. We propose that changes in mitochondrial and energy status regulate RNA splicing and that splicing is a resilience strategy that preserves energetic homeostasis with aging.-
dc.description.sponsorshipThis research was supported by the Intramural Research Program of the National Institute on Aging, NIH.-
dc.language.isoen-
dc.publisherSPRINGERNATURE-
dc.titleThe energy-splicing resilience axis hypothesis of aging-
dc.typeJournal Contribution-
dc.identifier.epage185-
dc.identifier.issue3-
dc.identifier.spage182-
dc.identifier.volume2-
local.format.pages4-
local.bibliographicCitation.jcatA2-
dc.description.notesFerrucci, L (corresponding author), NIA, Biomed Res Ctr, NIH, Baltimore, MD 21224 USA.-
dc.description.notesferruccilu@grc.nia.nih.gov-
local.publisher.placeCAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedEditorial Material-
local.classdsPublValOverrule/author_version_not_expected-
dc.identifier.doi10.1038/s43587-022-00189-w-
dc.identifier.isi000916575600002-
local.provider.typewosris-
local.description.affiliation[Ferrucci, Luigi; Donega, Stefano; Gorospe, Myriam] NIA, Biomed Res Ctr, NIH, Baltimore, MD 21224 USA.-
local.description.affiliation[Wilson, David M., III] Hasselt Univ, Biomed Res Inst, Diepenbeek, Belgium.-
local.uhasselt.internationalyes-
item.fullcitationFerrucci, Luigi; WILSON, David; Donega, Stefano & Gorospe, Myriam (2022) The energy-splicing resilience axis hypothesis of aging. In: Nature aging, 2 (3) , p. 182 -185.-
item.accessRightsRestricted Access-
item.fulltextWith Fulltext-
item.contributorFerrucci, Luigi-
item.contributorWILSON, David-
item.contributorDonega, Stefano-
item.contributorGorospe, Myriam-
crisitem.journal.eissn2662-8465-
Appears in Collections:Research publications
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