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http://hdl.handle.net/1942/39641
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DC Field | Value | Language |
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dc.contributor.author | Blanter, Marfa | - |
dc.contributor.author | Cockx, Maaike | - |
dc.contributor.author | Wittebols, Liesel | - |
dc.contributor.author | Abouelasrar Salama, Sara | - |
dc.contributor.author | DE BONDT, Mirre | - |
dc.contributor.author | Berghmans, Nele | - |
dc.contributor.author | Pörtner, Noemie | - |
dc.contributor.author | VANBRABANT, Lotte | - |
dc.contributor.author | Lorent, Natalie | - |
dc.contributor.author | GOUWY, Mieke | - |
dc.contributor.author | Struyf, S | - |
dc.date.accessioned | 2023-03-06T15:43:15Z | - |
dc.date.available | 2023-03-06T15:43:15Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2023-03-02T08:23:44Z | - |
dc.identifier.citation | International journal of molecular sciences (Print), 23 (359) -19 (Art N° 4558) | - |
dc.identifier.uri | http://hdl.handle.net/1942/39641 | - |
dc.description.abstract | Neutrophils are the most abundant circulating and first-responding innate myeloid cells and have so far been underestimated in the context of multiple sclerosis (MS). MS is the most frequent, immune-mediated, inflammatory disease of the central nervous system. MS is treatable but not curable and its cause(s) and pathogenesis remain elusive. The involvement of neutrophils in MS pathogenesis has been suggested by the use of preclinical animal disease models, as well as on the basis of patient sample analysis. In this review, we provide an overview of the possible mechanisms and functions by which neutrophils may contribute to the development and pathology of MS. Neutrophils display a broad variety of effector functions enabling disease pathogenesis, including (1) the release of inflammatory mediators and enzymes, such as interleukin-1 beta, myeloperoxidase and various proteinases, (2) destruction and phagocytosis of myelin (as debris), (3) release of neutrophil extracellular traps, (4) production of reactive oxygen species, (5) breakdown of the blood-brain barrier and (6) generation and presentation of autoantigens. An important question relates to the issue of whether neutrophils exhibit a predominantly proinflammatory function or are also implicated in the resolution of chronic inflammatory responses in MS. | - |
dc.description.sponsorship | This research was supported by the Fund for Scientific Research of Flanders, C1 funding (Grant C16/17/010) from KU Leuven and the COST Action (BM1407; “BEAT-PCD”). In addition, MBL and MDB are supported by PhD fellowships and SAS by a postdoctoral fellowship of FWO-Vlaanderen. | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/ publicdoma in/ zero/1. 0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | - |
dc.subject.other | neutrophils | - |
dc.subject.other | multiple sclerosis | - |
dc.subject.other | autoimmunity | - |
dc.subject.other | antigen presentation | - |
dc.title | Sputum from patients with primary ciliary dyskinesia contains high numbers of dysfunctional neutrophils and inhibits efferocytosis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 19 | - |
dc.identifier.issue | 359 | - |
dc.identifier.volume | 23 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 4558 | - |
dc.identifier.doi | 10.1186/s12931-022-02280-7 | - |
local.provider.type | Web of Science | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.contributor | Blanter, Marfa | - |
item.contributor | Cockx, Maaike | - |
item.contributor | Wittebols, Liesel | - |
item.contributor | Abouelasrar Salama, Sara | - |
item.contributor | DE BONDT, Mirre | - |
item.contributor | Berghmans, Nele | - |
item.contributor | Pörtner, Noemie | - |
item.contributor | VANBRABANT, Lotte | - |
item.contributor | Lorent, Natalie | - |
item.contributor | GOUWY, Mieke | - |
item.contributor | Struyf, S | - |
item.validation | vabb 2024 | - |
item.fullcitation | Blanter, Marfa; Cockx, Maaike; Wittebols, Liesel; Abouelasrar Salama, Sara; DE BONDT, Mirre; Berghmans, Nele; Pörtner, Noemie; VANBRABANT, Lotte; Lorent, Natalie; GOUWY, Mieke & Struyf, S (2020) Sputum from patients with primary ciliary dyskinesia contains high numbers of dysfunctional neutrophils and inhibits efferocytosis. In: International journal of molecular sciences (Print), 23 (359) -19 (Art N° 4558). | - |
crisitem.journal.issn | 1661-6596 | - |
crisitem.journal.eissn | 1422-0067 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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s12931-022-02280-7.pdf | Published version | 2.6 MB | Adobe PDF | View/Open |
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