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Title: | The Dark Side of an Essential Amino Acid: L-Arginine in Spinal Cord Injury | Authors: | ERENS, Celine VAN BROECKHOVEN, Jana BRONCKAERS, Annelies LEMMENS, Stefanie HENDRIX, Sven |
Issue Date: | 2023 | Publisher: | MARY ANN LIEBERT, INC | Source: | JOURNAL OF NEUROTRAUMA, 40 (9-10), p. 820-832 | Abstract: | L-arginine is a semi-essential amino acid involved in a variety of physiological processes in the central nervous system (CNS). It is essential in the survival and functionality of neuronal cells. Nonetheless, L-arginine also has a dark side; it potentiates neuroinflammation and nitric oxide (NO) production, leading to secondary damage. Therefore, modulating the L-arginine metabolism is challenging because both detrimental and beneficial effects are dependent on this semi-essential amino acid. After spinal cord injury (SCI), L-arginine plays a crucial role in trauma-induced neuroinflammation and regenerative processes via the two key enzymes: nitric oxide synthase (NOS) and arginase (ARG). Studies on L-arginine metabolism using ARG and NOS inhibitors highlighted the conflicting role of this semi-essential amino acid. Similarly, L-arginine supplementation resulted in both negative and positive outcomes after SCI. However, new data indicate that arginine depletion substantially improves spinal cord regeneration after injury. Here, we review the challenging characteristics of L-arginine metabolism as a therapeutic target after SCI. | Notes: | Hendrix, S (corresponding author), Med Sch Hamburg, Kaiserkai 1, D-20457 Hamburg, Germany. sven.hendrix@medicalschool-hamburg.de |
Keywords: | amino acid;L-arginine;metabolism;spinal cord injury | Document URI: | http://hdl.handle.net/1942/39714 | ISSN: | 0897-7151 | e-ISSN: | 1557-9042 | DOI: | 10.1089/neu.2022.0271 | ISI #: | 000934600400001 | Rights: | Mary Ann Liebert, Inc | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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NEU-2022-0271-ver9-Erens_2P 1..13.pdf Restricted Access | Early view | 380.56 kB | Adobe PDF | View/Open Request a copy |
Dark side of arginine revised manuscript (1).pdf | Peer-reviewed author version | 430.83 kB | Adobe PDF | View/Open |
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