Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/39721
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dc.contributor.authorMahmoudinezhad, Mahsa-
dc.contributor.authorKhosravaniardakani, Sheida-
dc.contributor.authorBadelou, Leila Saljoughi-
dc.contributor.authorFayyazishishavan, Ehsan-
dc.contributor.authorKAHROBA, Houman-
dc.contributor.authorFarhangi, Mahdieh Abbasalizad-
dc.date.accessioned2023-03-16T10:01:08Z-
dc.date.available2023-03-16T10:01:08Z-
dc.date.issued2023-
dc.date.submitted2023-03-14T15:19:17Z-
dc.identifier.citationBMC Endocrine Disorders, 23 (1) (Art N° 41)-
dc.identifier.urihttp://hdl.handle.net/1942/39721-
dc.description.abstractBackgroundRecent studies have shown that dietary intakes and gene variants have a critical role in the obesity related comorbidities. This study aimed to evaluate the effects of the interactions between Fatty acid desaturase 2 (FADS2) gene rs174583 polymorphism and two dietary indices on cardiometabolic risk factors.MethodsThis cross-sectional study was carried out on 347 obese adults aged 20-50 years old in Tabriz, Iran. Healthy eating index (HEI) and Diet quality index-international (DQI-I) were evaluated by a validated semi-quantitative 147-item Food frequency questionnaire (FFQ). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine FADS2 gene variants. Multivariate analysis of covariance (MANCOVA) was used to identify gene-diet interactions on metabolic parameters.ResultsWaist circumference (WC) and serum triglyceride (TG) levels were significantly higher among carriers of TT genotype of FADS2 gene (P < 0.05). In addition, the interactions between FADS2 gene rs174583 polymorphism and DQI-I had significant effects on weight (P (interaction) = 0.01), fat mass (P (interaction) = 0.04), fat free mass (P (interaction) = 0.03), and Body mass index (BMI) (P (interaction) = 0.02); the highest level of these parameters belonged to TT carriers. Similarly, the interactions between FADS2 gene variants and HEI had significant effects on insulin (P (interaction) < 0.001), Homeostasis model assessment of insulin resistance (HOMA-IR) (P (interaction) < 0.001), Quantitative insulin check index (QUICKI) (P (interaction) = 0.001), and alpha Melanocyte stimulating hormone (alpha-MSH) (P (interaction) = 0.03).ConclusionIn this study, for the first time, we reported the effects of gene-diet interactions on metabolic traits. Compliance with dietary indices (DQI-I and HEI) ameliorated the adverse effects of gene variants on metabolic risk factors, especially in heterogeneous genotypes. Further prospective cohort studies are needed to confirm these results.-
dc.description.sponsorshipThis study was fnancially supported by a grant from Tabriz University of Medical Sciences, Iran (Identifers: IR.TBZMED.REC.1399.062. and IR.TBZMED. REC.1398.460) We thank all the study participants. We also thank Research Undersecretary of Tabriz University of Medical Sciences for their fnancial support (Grant number: 64111)-
dc.language.isoen-
dc.publisherBMC-
dc.rightsThe Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.-
dc.subject.otherFatty acid desaturase-
dc.subject.otherDiet quality index-international-
dc.subject.otherHealthy eating index-
dc.subject.otherObesity-
dc.titleThe integrative panel of fatty acid desaturase-2 (FADS2) rs174583 gene polymorphism and dietary indices (DQI-I and HEI) affects cardiovascular risk factors among obese individuals-
dc.typeJournal Contribution-
dc.identifier.issue1-
dc.identifier.volume23-
local.bibliographicCitation.jcatA1-
dc.description.notesFarhangi, MA (corresponding author), Tabriz Univ Med Sci, Drug Appl Res Ctr, Attar Neishabouri Ave,Golgasht St, Tabriz 5165665931, Iran.; Farhangi, MA (corresponding author), Tabriz Univ Med Sci, Fac Nutr, Dept Community Nutr, Tabriz, Iran.-
dc.description.notesabbasalizad_m@yahoo.com-
local.publisher.placeCAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr41-
dc.identifier.doi10.1186/s12902-023-01289-3-
dc.identifier.pmid36788508-
dc.identifier.isi000933492400002-
dc.contributor.orcidFayyazishishavan, Ehsan/0000-0002-9548-6028-
local.provider.typewosris-
local.description.affiliation[Mahmoudinezhad, Mahsa] Tabriz Univ Med Sci, Mol Med Res Ctr, Tabriz, Iran.-
local.description.affiliation[Khosravaniardakani, Sheida] Florida Int Univ, Robert Stempel Coll Publ Hlth, Dept Epidemiol, 1240 SW108 AVE,Path,Univ Pk, Miami, FL 33174 USA.-
local.description.affiliation[Badelou, Leila Saljoughi] Shahid Beheshti Univ Med Sci, Sch Med, Dept Internal Med, Tehran, Iran.-
local.description.affiliation[Fayyazishishavan, Ehsan] Univ Texas Hlth Sci Ctr Houston UTHealth, Sch Publ Hlth, Dept Biostat & Data Sci, Houston, TX 77030 USA.-
local.description.affiliation[Kahroba, Houman] Maastricht Univ, GROW Sch Oncol & Dev Biol, Dept Toxicogen, Maastricht, Netherlands.-
local.description.affiliation[Kahroba, Houman] Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium.-
local.description.affiliation[Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Drug Appl Res Ctr, Attar Neishabouri Ave,Golgasht St, Tabriz 5165665931, Iran.-
local.description.affiliation[Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Fac Nutr, Dept Community Nutr, Tabriz, Iran.-
local.uhasselt.internationalyes-
item.fulltextWith Fulltext-
item.fullcitationMahmoudinezhad, Mahsa; Khosravaniardakani, Sheida; Badelou, Leila Saljoughi; Fayyazishishavan, Ehsan; KAHROBA, Houman & Farhangi, Mahdieh Abbasalizad (2023) The integrative panel of fatty acid desaturase-2 (FADS2) rs174583 gene polymorphism and dietary indices (DQI-I and HEI) affects cardiovascular risk factors among obese individuals. In: BMC Endocrine Disorders, 23 (1) (Art N° 41).-
item.contributorMahmoudinezhad, Mahsa-
item.contributorKhosravaniardakani, Sheida-
item.contributorBadelou, Leila Saljoughi-
item.contributorFayyazishishavan, Ehsan-
item.contributorKAHROBA, Houman-
item.contributorFarhangi, Mahdieh Abbasalizad-
item.accessRightsOpen Access-
crisitem.journal.eissn1472-6823-
Appears in Collections:Research publications
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