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http://hdl.handle.net/1942/39778
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DC Field | Value | Language |
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dc.contributor.author | Prieto-Botella, Daniel | - |
dc.contributor.author | MARTENS, Dries | - |
dc.contributor.author | Valera-Gran, Desiree | - |
dc.contributor.author | Subiza-Pérez, Mikel | - |
dc.contributor.author | Tardón, Adonina | - |
dc.contributor.author | Lozano, Manuel | - |
dc.contributor.author | Casas, Maribel | - |
dc.contributor.author | Bustamante, Mariona | - |
dc.contributor.author | Jimeno-Romero, Alba | - |
dc.contributor.author | Fernández-Somoano, Ana | - |
dc.contributor.author | Llop, Sabrina | - |
dc.contributor.author | Vrijheid, Martine | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | Navarrete-Muñoz, Eva-María | - |
dc.date.accessioned | 2023-03-21T10:38:51Z | - |
dc.date.available | 2023-03-21T10:38:51Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-03-16T09:43:15Z | - |
dc.identifier.citation | International Journal of Environmental Research and Public Health, 20 (6) (Art N° 5134) | - |
dc.identifier.uri | http://hdl.handle.net/1942/39778 | - |
dc.description.abstract | Sedentary behaviour (SB) may be related to telomere length (TL) attrition due to a possible pro-inflammatory effect. This study examined the association between parent-reported sedentary behaviour (SB) and leukocyte TL at the age of 4 and telomere tracking from 4 to 8 years. In the Spanish birth cohort Infancia y Medio Ambiente (INMA) project, we analysed data from children who attended follow-up visits at age 4 (n = 669) and 8 (n = 530). Multiple robust regression models were used to explore the associations between mean daily hours of SB (screen time, other sedentary activities, and total SB) at 4 years categorised into tertiles and TL at 4 years and difference in TL rank between age 4 and 8, respectively. At the age of 4, the results showed that children with the highest screen time (1.6–5.0 h/day) had a shorter TL of −3.9% (95% CI: −7.4, −0.4; p = 0.03) compared with children in the lowest tertile (0.0–1.0 h/day). Between 4 and 8 years, a higher screen time (highest tertile group vs. lowest tertile) was associated with a decrease in the LTL rank of −1.9% (95% CI: −3.8, −0.1; p = 0.03) from 4 to 8 years. Children exposed to a higher screen time at 4 years were more prone to have shorter TL at 4 and between 4 and 8 years of age. This study supports the potential negative effect of SB during childhood on cellular longevity. | - |
dc.description.sponsorship | This research was funded by the Instituto de Salud Carlos III/Agencia Estatal de Investigación (PI18/00825: “Dieta y actividad física en embarazo y tras el nacimiento y longitud del telómero en niños y adolescentes: Proyecto TeloDiPA” and European Regional Development Fund (ERDF): “Una manera de hacer Europa”); the Generalitat Valenciana (GVA/2021/191, CIAICO/2021/132); the Instituto de Salud Carlos III (FIS-PI09/00090, PI04/2018, PI09/02311, PI13/02429, PI16/1288, PI18/00909, PI19/1338 and FIS-PI18/01142 incl. ERFD funds, PS20/0006), the Department of Health of the Basque Government (2013111089); the Instituto de Salud Carlos III (FIS-PI13/02187 and FISPI18/01142 incl. ERFD funds), the Department of Health of the Basque Government (2015111065), and the Provincial Government of Gipuzkoa (DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain); Obra Social Cajastur/Fundación Liberbank and Universidad de Oviedo; and Gobierno de España through Ministeriode Universidades under the grants CAS21/00008 and NextGenerationEU. DPB was supported by the Miguel Hernández University (Ayudas Movilidad Internacional 2021, Erasmus+ 2021) during the development of this study. In addition, DM holds a postdoctoral grant by the Flemish Scientific Fund (FWO grant 12X9620N). The funders had no role in the design of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval and submission of the manuscript. The APC was funded by PI18/00825. | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | - |
dc.subject.other | lifestyle | - |
dc.subject.other | children | - |
dc.subject.other | genetics | - |
dc.subject.other | screen time | - |
dc.subject.other | epigenetics | - |
dc.subject.other | cellular longevity | - |
dc.title | Sedentary Behaviour and Telomere Length Shortening during Early Childhood: Evidence from the Multicentre Prospective INMA Cohort Study | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 6 | - |
dc.identifier.volume | 20 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 5134 | - |
dc.identifier.doi | 10.3390/ijerph20065134 | - |
local.provider.type | CrossRef | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.contributor | Prieto-Botella, Daniel | - |
item.contributor | MARTENS, Dries | - |
item.contributor | Valera-Gran, Desiree | - |
item.contributor | Subiza-Pérez, Mikel | - |
item.contributor | Tardón, Adonina | - |
item.contributor | Lozano, Manuel | - |
item.contributor | Casas, Maribel | - |
item.contributor | Bustamante, Mariona | - |
item.contributor | Jimeno-Romero, Alba | - |
item.contributor | Fernández-Somoano, Ana | - |
item.contributor | Llop, Sabrina | - |
item.contributor | Vrijheid, Martine | - |
item.contributor | NAWROT, Tim | - |
item.contributor | Navarrete-Muñoz, Eva-María | - |
item.fullcitation | Prieto-Botella, Daniel; MARTENS, Dries; Valera-Gran, Desiree; Subiza-Pérez, Mikel; Tardón, Adonina; Lozano, Manuel; Casas, Maribel; Bustamante, Mariona; Jimeno-Romero, Alba; Fernández-Somoano, Ana; Llop, Sabrina; Vrijheid, Martine; NAWROT, Tim & Navarrete-Muñoz, Eva-María (2023) Sedentary Behaviour and Telomere Length Shortening during Early Childhood: Evidence from the Multicentre Prospective INMA Cohort Study. In: International Journal of Environmental Research and Public Health, 20 (6) (Art N° 5134). | - |
crisitem.journal.issn | 1661-7827 | - |
crisitem.journal.eissn | 1660-4601 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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ijerph-20-05134-v3.pdf | Published version | 673.91 kB | Adobe PDF | View/Open |
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