Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/39825
Title: Barrier Films and Dressings for the Prevention of Acute Radiation Dermatitis: A Systematic Review and Meta-Analysis
Authors: ROBIJNS, Jolien 
Aquilano, Michele
Banerjee, Suvam
Caini, Saverio
Wolf, Julie Ryan
van den Hurk, Corina
Beveridge, Mara
Lam, Henry
Bonomo, Pierluigi
Chow, Edward
Behroozian, Tara
Issue Date: 2023
Publisher: 
Source: SUPPORTIVE CARE IN CANCER, 31 (4) (Art N° 219)
Abstract: Purpose This systematic review and meta-analysis aimed to evaluate the efficacy of barrier films and dressings in preventing acute radiation dermatitis (RD). Methods OVID Medline, Embase, and Cochrane databases were searched from 1946 to September 2020 to identify randomized controlled trials on the use of barrier films or dressings to prevent RD. For comparable outcomes between studies, pooled effect sizes and 95% confidence intervals (CI) were calculated using the random effects analysis in RevMan 5.4. Results Fourteen and 11 studies were included in the qualitative and quantitative analyses, respectively. Five types of barrier films used for RD were identified: Hydrofilm, StrataXRT®, Mepitel® Film, 3 M™ Cavilon™ No-Sting Barrier Film, and silver leaf nylon dressing. Hydrofilm and Mepitel Film significantly reduced the development of RD grade ≥ 2 in breast and head and neck cancer patients (RR 0.32, 95%CI 0.19, 0.56, p < 0.0001; RR 0.21, 95%CI 0.05, 0.89, p = 0.03, resp.). Moreover, Hydrofilm had a beneficial effect on patient-reported outcomes (PROs) (SMD -0.75, 95%CI -1.2, -0.29, p = 0.001). The meta-analyses on the other barrier films did not show any significant effect. Conclusion This review and meta-analysis demonstrated that Hydrofilm and Mepitel Film could effectively reduce RD severity and improve PROs. The evidence is generally weak for all the studies on barrier films and dressings due to a limited study number, high risk of bias, small sample sizes, and minimal comparable outcome measures. It’s potential has been proven, but future research in this field is recommended to confirm the efficacy of these products and assess real-world feasibility.
Keywords: Radiation dermatitis;Supportive care;Oncodermatology;Oncology;Cancer;Systematic review;Meta-analysis;Radiationdermatitis;Radiotherapy;Barrier films;Barrier dressings
Document URI: http://hdl.handle.net/1942/39825
ISSN: 0941-4355
e-ISSN: 1433-7339
DOI: 10.1007/s00520-023-07671-0
ISI #: 000952266400004
Rights: The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023
Category: A1
Type: Journal Contribution
Appears in Collections:Research publications

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