Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/39844
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | COLYN, William | - |
dc.contributor.author | Azari, F. | - |
dc.contributor.author | BELLEMANS, Johan | - |
dc.contributor.author | Lenthe, G. Harry van | - |
dc.contributor.author | Scheys, L. | - |
dc.date.accessioned | 2023-03-27T10:59:22Z | - |
dc.date.available | 2023-03-27T10:59:22Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-03-24T12:19:32Z | - |
dc.identifier.citation | EUROPEAN CELLS & MATERIALS, 45 , p. 60 -71 | - |
dc.identifier.uri | http://hdl.handle.net/1942/39844 | - |
dc.description.abstract | Recent studies highlighted the crucial contribution of subchondral bone to OA development. Yet, only limited data have been reported on the relation between alteration to cartilage morphology, structural properties of the subchondral bone plate (SBP) and underlying subchondral trabecular bone (STB). Furthermore, the relationship between the morphometry of the cartilage and bone in the tibial plateau and the OA-induced changes in the joint's mechanical axis remains unexplored. Therefore, a visualisation and quantification of cartilage and subchondral bone microstructure in the medial tibial plateau was performed. End stage knee-OA patients with varus alignment and scheduled for total knee arthroplasty (TKA) underwent preoperative full-length radiography to measure the hip-knee-ankle angle (HKA) and the mechanical-axis deviation (MAD). 18 tibial plateaux were mu-CT scanned (20.1 mu m/voxel). Cartilage thickness, SBP, and STB microarchitecture were quantified in 10 volumes of interest (VOIs) in each medial tibial plateau. Significant differences (p < 0.001) were found for cartilage thickness, SBP, and STB microarchitecture parameters among the VOIs. Closer to the mechanical axis, cartilage thickness was consistently smaller, while SBP thickness and STB bone volume fraction (BV/TV) were higher. Moreover, trabeculae were also more superior-inferiorly oriented, i.e. perpendicular to the transverse plane of the tibial plateau. As cartilage and subchondral bone changes reflect responses to local mechanical loading patterns in the joint, the results suggested that region-specific subchondral bone adaptations were related to the degree of varus deformity. More specifically, subchondral sclerosis appeared to be most pronounced closer to the mechanical axis of the knee. | - |
dc.description.sponsorship | This study was part of Limburg Clinical Research Centre supported by Hasselt University, Ziekenhuis Oost-Limburg and Jessa Hospital and was funded in part by KU Leuven Internal Funds, Grant C24/16/027”. Study concept and design: Colyn, Bellemans, Van Lenthe, Scheys; Data acquisition: Colyn, Azari; Statistical analysis: Azari; Data Interpretation: all; Manuscript preparation: Colyn, Azari; Revision of Manuscript drafts: all. | - |
dc.language.iso | en | - |
dc.publisher | AO RESEARCH INSTITUTE DAVOS-ARI | - |
dc.rights | This article is distributed in accordance with Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/). | - |
dc.subject.other | Osteoarthritis | - |
dc.subject.other | subchondral bone | - |
dc.subject.other | tibial plateau | - |
dc.subject.other | varus alignment | - |
dc.subject.other | ?CT | - |
dc.title | MICROSTRUCTURAL ADAPTATIONS OF THE SUBCHONDRAL BONE ARE RELATED TO THE MECHANICAL AXIS DEVIATION IN END STAGE VARUS OA KNEES | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 71 | - |
dc.identifier.spage | 60 | - |
dc.identifier.volume | 45 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Colyn, W (corresponding author), AZ Turnhout, Dept Orthopaed Surg, Steenweg Op Merksplas 44, B-2300 Turnhout, Belgium. | - |
dc.description.notes | william_colyn@hotmail.com | - |
local.publisher.place | CLAVADELERSTRASSE 8, DAVOS, CH 7270, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.22203/eCM.v045a05 | - |
dc.identifier.pmid | 36808322 | - |
dc.identifier.isi | 000946350000001 | - |
dc.contributor.orcid | Scheys, Lennart/0000-0002-1727-533X | - |
local.provider.type | wosris | - |
local.description.affiliation | [Colyn, W.] AZ Turnhout, Dept Orthopaed Surg, Steenweg Op Merksplas 44, B-2300 Turnhout, Belgium. | - |
local.description.affiliation | [Colyn, W.; Bellemans, J.] Hasselt Univ, Fac Med & Life Sci, Diepenbeek, Belgium. | - |
local.description.affiliation | [Colyn, W.] ZOL Genk, Limburg Clin Res Ctr, Genk, Belgium. | - |
local.description.affiliation | [Azari, F.; Lenthe, G. Harry van] Katholieke Univ Leuven, Biomech Sect, Leuven, Belgium. | - |
local.description.affiliation | [Bellemans, J.] ZOL Genk, Dept Orthopaed Surg, Genk, Belgium. | - |
local.description.affiliation | [Bellemans, J.] GRIT Belgian Sports Clin, Leuven, Belgium. | - |
local.description.affiliation | [Scheys, L.] Univ Hosp Leuven, Dept Orthopaed, Leuven, Belgium. | - |
local.uhasselt.international | no | - |
item.fullcitation | COLYN, William; Azari, F.; BELLEMANS, Johan; Lenthe, G. Harry van & Scheys, L. (2023) MICROSTRUCTURAL ADAPTATIONS OF THE SUBCHONDRAL BONE ARE RELATED TO THE MECHANICAL AXIS DEVIATION IN END STAGE VARUS OA KNEES. In: EUROPEAN CELLS & MATERIALS, 45 , p. 60 -71. | - |
item.contributor | COLYN, William | - |
item.contributor | Azari, F. | - |
item.contributor | BELLEMANS, Johan | - |
item.contributor | Lenthe, G. Harry van | - |
item.contributor | Scheys, L. | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 1473-2262 | - |
crisitem.journal.eissn | 1473-2262 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
v045a05.pdf | Published version | 1.78 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.