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Title: | Hallmarks of neurodegenerative diseases | Authors: | WILSON, David Cookson, Mark R. Van Den Bosch , Ludo Zetterberg, Henrik Holtzman, David M. DEWACHTER, Ilse |
Issue Date: | 2023 | Publisher: | CELL PRESS | Source: | CELL, 186 (4) , p. 693 -714 | Abstract: | Decades of research have identified genetic factors and biochemical pathways involved in neurodegenera-tive diseases (NDDs). We present evidence for the following eight hallmarks of NDD: pathological protein ag-gregation, synaptic and neuronal network dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy homeostasis, DNA and RNA defects, inflammation, and neuronal cell death. We describe the hallmarks, their biomarkers, and their interactions as a framework to study NDDs using a holistic approach. The framework can serve as a basis for defining pathogenic mechanisms, categorizing different NDDs based on their primary hallmarks, stratifying patients within a specific NDD, and designing multi-tar-geted, personalized therapies to effectively halt NDDs. | Notes: | Wilson, DM; Dewachter, I (corresponding author), Hasselt Univ, Biomed Res Inst, BIOMED, B-3500 Hasselt, Belgium. david.wilson@uhasselt.be; ilse.dewachter@uhasselt.be |
Keywords: | DNA and RNA defects;cytoskeletal defects;energy homeostasis;hallmarks;inflammation;neurodegeneration;neurodegenerative disease;protein aggregation;proteostasis;synaptic and neuronal network dysfunction;Humans;Proteostasis;Protein Aggregation, Pathological;Cell Death;Cytoskeleton;Neurodegenerative Diseases | Document URI: | http://hdl.handle.net/1942/39849 | ISSN: | 0092-8674 | e-ISSN: | 1097-4172 | DOI: | 10.1016/j.cell.2022.12.032 | ISI #: | 000943824200001 | Rights: | 2022 The Author(s). Published by Elsevier Inc. 693 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Hallmarks of neurodegenerative diseases.pdf | Published version | 3.47 MB | Adobe PDF | View/Open |
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